ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SIK2
Previous Symbol	SNF1LK2
Symbol Alias	KIAA0781, QIK, DKFZp434K1115, LOH11CR1I
Approved Name	salt-inducible kinase 2
Previous Name	SNF1-like kinase 2
Location	11q23.1
Position	chr11:111473115-111601577, +
External Links	HGNC: 21680 Entrez Gene: 23235 Ensembl: ENSG00000170145 UCSC: uc001plt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046777	protein autophosphorylation	Biological Process	IDA[18348280]	23
GO:0008286	insulin receptor signaling pathway	Biological Process		32
GO:0046626	regulation of insulin receptor signaling pathway	Biological Process		1
GO:0006468	protein phosphorylation	Biological Process	IDA[14976552]	53
GO:0007243	intracellular protein kinase cascade	Biological Process	IDA[14976552]	19
GO:0005737	cytoplasm	Cellular Component		690
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005634	nucleus	Cellular Component		770
GO:0005524	ATP binding	Molecular Function	IDA[14976552]	228
GO:0005515	protein binding	Molecular Function		910
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[18348280]	61
GO:0000287	magnesium ion binding	Molecular Function	IDA[14976552]	28

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SIK2 (count: 33)

Gene Symbol	Pathway Count	Pathway List
MARK2	8	protein autophosphorylation; protein phosphorylation; intracellular protein kinase cascade; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity; magnesium ion binding;
NEK6	8	protein autophosphorylation; protein phosphorylation; cytoplasm; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity; magnesium ion binding;
PRKD1	8	protein autophosphorylation; intracellular protein kinase cascade; cytoplasm; Golgi apparatus; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity;
RPS6KA4	8	protein phosphorylation; intracellular protein kinase cascade; cytoplasm; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity; magnesium ion binding;
PAK1	7	protein autophosphorylation; protein phosphorylation; cytoplasm; Golgi apparatus; ATP binding; protein binding; protein serine/threonine kinase activity;
TSSK2	7	protein autophosphorylation; protein phosphorylation; cytoplasm; ATP binding; protein binding; protein serine/threonine kinase activity; magnesium ion binding;
MAPK1	7	insulin receptor signaling pathway; cytoplasm; Golgi apparatus; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity;
STK36	7	protein phosphorylation; cytoplasm; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity; magnesium ion binding;
MAP3K11	6	protein autophosphorylation; protein phosphorylation; cytoplasm; ATP binding; protein binding; protein serine/threonine kinase activity;
SMG1	6	protein autophosphorylation; cytoplasm; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity;
WNK2	6	protein autophosphorylation; protein phosphorylation; intracellular protein kinase cascade; cytoplasm; ATP binding; protein serine/threonine kinase activity;
MAPK3	6	insulin receptor signaling pathway; protein phosphorylation; Golgi apparatus; nucleus; ATP binding; protein binding;
CDC42BPG	6	protein phosphorylation; cytoplasm; ATP binding; protein binding; protein serine/threonine kinase activity; magnesium ion binding;
GSK3B	6	protein phosphorylation; cytoplasm; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity;
LATS2	6	protein phosphorylation; intracellular protein kinase cascade; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity;
PRKCB	6	protein phosphorylation; cytoplasm; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity;
SIK3	6	protein phosphorylation; cytoplasm; ATP binding; protein binding; protein serine/threonine kinase activity; magnesium ion binding;
ERBB2	5	protein autophosphorylation; protein phosphorylation; nucleus; ATP binding; protein binding;
FES	5	protein autophosphorylation; protein phosphorylation; cytoplasm; Golgi apparatus; ATP binding;
FLT4	5	protein autophosphorylation; cytoplasm; nucleus; ATP binding; protein binding;
PRKAA1	5	insulin receptor signaling pathway; protein phosphorylation; nucleus; ATP binding; protein binding;
AURKC	5	protein phosphorylation; cytoplasm; nucleus; ATP binding; protein serine/threonine kinase activity;
CSNK1E	5	protein phosphorylation; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity;
FRK	5	protein phosphorylation; cytoplasm; nucleus; ATP binding; protein binding;
ILK	5	protein phosphorylation; cytoplasm; ATP binding; protein binding; protein serine/threonine kinase activity;
LATS1	5	protein phosphorylation; ATP binding; protein binding; protein serine/threonine kinase activity; magnesium ion binding;
MAP4K2	5	protein phosphorylation; intracellular protein kinase cascade; ATP binding; protein binding; protein serine/threonine kinase activity;
PLK1	5	protein phosphorylation; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity;
PRKG1	5	protein phosphorylation; cytoplasm; Golgi apparatus; ATP binding; protein binding;
ROCK2	5	protein phosphorylation; nucleus; ATP binding; protein binding; protein serine/threonine kinase activity;
TSSK4	5	protein phosphorylation; ATP binding; protein binding; protein serine/threonine kinase activity; magnesium ion binding;
GAK	5	cytoplasm; Golgi apparatus; ATP binding; protein binding; protein serine/threonine kinase activity;
SNCA	5	cytoplasm; Golgi apparatus; nucleus; protein binding; magnesium ion binding;

Genes shared at least 2 KEGG pathways with SIK2 (count: 0)

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Region: chr11:111473115..111601577 View in gBrowse