ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MAP4K2
Previous Symbol	RAB8IP
Symbol Alias	GCK, BL44
Approved Name	mitogen-activated protein kinase kinase kinase kinase 2
Location	11q13.1
Position	chr11:64556290-64570713, -
External Links	HGNC: 6864 Entrez Gene: 5871 Ensembl: ENSG00000168067 UCSC: uc001obh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006468	protein phosphorylation	Biological Process	IDA[11784851]	53
GO:0005524	ATP binding	Molecular Function	IDA[11784851]	228
GO:0006950	response to stress	Biological Process	TAS[8643544]	30
GO:0006903	vesicle targeting	Biological Process		5
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[11784851]	61
GO:0000139	Golgi membrane	Cellular Component		95
GO:0005515	protein binding	Molecular Function	IPI[11784851]	910
GO:0005083	small GTPase regulator activity	Molecular Function		5
GO:0007254	JNK cascade	Biological Process	TAS[7477268]	11
GO:0007257	activation of JUN kinase activity	Biological Process	IDA[17584736]	8
GO:0006955	immune response	Biological Process	TAS[7515885]	45
GO:0007243	intracellular protein kinase cascade	Biological Process	IDA[11784851]	19
GO:0045087	innate immune response	Biological Process		54
GO:0046330	positive regulation of JNK cascade	Biological Process	IDA[17584736]	12
GO:0016323	basolateral plasma membrane	Cellular Component		29
GO:0031435	mitogen-activated protein kinase kinase kinase binding	Molecular Function	IPI[17584736]	7

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with MAP4K2 (count: 11)

Gene Symbol	Pathway Count	Pathway List
MAP3K11	8	protein phosphorylation; ATP binding; protein serine/threonine kinase activity; protein binding; JNK cascade; activation of JUN kinase activity; positive regulation of JNK cascade; mitogen-activated protein kinase kinase kinase binding;
MAPK1	6	ATP binding; response to stress; protein serine/threonine kinase activity; protein binding; innate immune response; mitogen-activated protein kinase kinase kinase binding;
MAPK9	6	ATP binding; response to stress; protein binding; JNK cascade; innate immune response; mitogen-activated protein kinase kinase kinase binding;
CDC42BPG	5	protein phosphorylation; ATP binding; protein serine/threonine kinase activity; protein binding; small GTPase regulator activity;
LATS2	5	protein phosphorylation; ATP binding; protein serine/threonine kinase activity; protein binding; intracellular protein kinase cascade;
MARK2	5	protein phosphorylation; ATP binding; protein serine/threonine kinase activity; protein binding; intracellular protein kinase cascade;
RPS6KA4	5	protein phosphorylation; ATP binding; protein serine/threonine kinase activity; protein binding; intracellular protein kinase cascade;
SIK2	5	protein phosphorylation; ATP binding; protein serine/threonine kinase activity; protein binding; intracellular protein kinase cascade;
SYK	5	protein phosphorylation; ATP binding; protein binding; activation of JUN kinase activity; innate immune response;
MAP3K5	5	ATP binding; protein binding; JNK cascade; activation of JUN kinase activity; innate immune response;
PRKD1	5	ATP binding; protein serine/threonine kinase activity; protein binding; intracellular protein kinase cascade; innate immune response;

Genes shared at least 2 KEGG pathways with MAP4K2 (count: 0)

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Region: chr11:64556290..64570713 View in gBrowse