ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0004674
Name protein serine/threonine kinase activity
Type Molecular Function
No. of Genes in ADHDgene  61
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 61)

Literature-origin genes (count: 7)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
DCLK1 doublecortin-like kinase 1 13q13.3 1(1/0/0)
DCLK2 doublecortin-like kinase 2 4q31.3 1(0/0/1)
CSNK1E casein kinase 1, epsilon 22q13.1 2(1/1/0) TAS[7797465]
MAP2K3 mitogen-activated protein kinase kinase 3 17q11.2 1(0/1/0)
BMPR1B bone morphogenetic protein receptor, type IB 4q23-q24 1(0/0/1) IDA[12065756]
TRIO triple functional domain (PTPRF interacting) 5p14-p15.1 1(0/0/1)
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0) IDA[11035810]

Genes from other sources Help (count: 54)

Approved Symbol Approved Name Source Evidence[PMID]
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 Mapped by significant region IDA[16278681]
PRKD1 protein kinase D1 Mapped by significant region IDA[18440775]; TAS[8119958]
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) Mapped by significant region IDA[15194684]; NAS[9341881]
TAOK2 TAO kinase 2 Mapped by CNV IDA[11279118]
WNK2 WNK lysine deficient protein kinase 2 Mapped by significant region
PLK1 polo-like kinase 1 Mapped by significant region IDA[19468302]
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 Mapped by significant region IDA[16574662]
AURKC aurora kinase C Mapped by LD-proxy
ATM ataxia telangiectasia mutated Mapped by CNV; Mapped by significant region IDA[9733515]
MARK4 MAP/microtubule affinity-regulating kinase 4 Mapped by PBA pathway IDA[15009667]
RIPK3 receptor-interacting serine-threonine kinase 3 Mapped by significant region TAS[10339433]
FASTK Fas-activated serine/threonine kinase Mapped by LD-proxy; Mapped by literature SNP IDA[7544399]
RIOK3 RIO kinase 3 (yeast) Mapped by significant region
SMG1 smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) Mapped by significant region IDA[19417104]; NAS[11331269]
STK32C serine/threonine kinase 32C Mapped by CNV
CHEK1 CHK1 checkpoint homolog (S. pombe) Mapped by significant region IDA[16963448]
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy IDA[15850461]
PHKG2 phosphorylase kinase, gamma 2 (testis) Mapped by CNV TAS[10487978]
STK36 serine/threonine kinase 36 Mapped by significant region TAS[10806483]
STK32B serine/threonine kinase 32B Mapped by CNV
ERN2 endoplasmic reticulum to nucleus signaling 2 Mapped by significant region IDA[11175748]
MYLK4 myosin light chain kinase family, member 4 Mapped by CNV
LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) Mapped by PBA pathway
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 Mapped by significant region IDA[9792677]; IMP[12773393]
TSSK4 testis-specific serine kinase 4 Mapped by significant region IDA[15964553]
STK31 serine/threonine kinase 31 Mapped by CNV; Mapped by significant region
SGK1 serum/glucocorticoid regulated kinase 1 Mapped by significant region
SPEG SPEG complex locus Mapped by significant region
PSKH2 protein serine kinase H2 Mapped by CNV
MARK2 MAP/microtubule affinity-regulating kinase 2 Mapped by significant region NAS[8274451]
ULK2 unc-51-like kinase 2 (C. elegans) Mapped by significant region IDA[18936157]
AATK apoptosis-associated tyrosine kinase Mapped by LD-proxy
TSSK2 testis-specific serine kinase 2 Mapped by CNV IDA[18533145]
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 Mapped by CNV
STK16 serine/threonine kinase 16 Mapped by significant region
ALPK2 alpha-kinase 2 Mapped by significant region
MAP3K11 mitogen-activated protein kinase kinase kinase 11 Mapped by significant region IDA[8195146]
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide Mapped by CNV
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 Mapped by significant region TAS[9878560]
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 Mapped by CNV
TGFBR1 transforming growth factor, beta receptor 1 Mapped by significant region IDA[18625725]
BCKDK branched chain ketoacid dehydrogenase kinase Mapped by CNV
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 Mapped by significant region IDA[11784851]
ILK integrin-linked kinase Mapped by CNV IDA[9366252]
TTK TTK protein kinase Mapped by PBA pathway
CPNE3 copine III Mapped by CNV IDA[11041869]
NEK6 NIMA (never in mitosis gene a)-related kinase 6 Mapped by significant region
SIK2 salt-inducible kinase 2 Mapped by significant region IDA[18348280]
ANKK1 ankyrin repeat and kinase domain containing 1 Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region
GAK cyclin G associated kinase Mapped by LD-proxy
SQSTM1 sequestosome 1 Mapped by CNV NAS[8618896]
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) Mapped by significant region IDA[10871863]
PRKCB protein kinase C, beta Mapped by significant region
SIK3 SIK family kinase 3 Mapped by significant region IDA[14976552]

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014