ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LATS2
Approved Name	LATS, large tumor suppressor, homolog 2 (Drosophila)
Previous Name	LATS (large tumor suppressor, Drosophila) homolog 2
Location	13q11-q12
Position	chr13:21547171-21635722, -
External Links	HGNC: 6515 Entrez Gene: 26524 Ensembl: ENSG00000150457 UCSC: uc001unr.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
13q12.11	chr13:19500000-23300000	1 (1/0/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0034613	cellular protein localization	Biological Process		9
GO:0030216	keratinocyte differentiation	Biological Process		9
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	Biological Process	IDA[12853976]	6
GO:0035329	hippo signaling cascade	Biological Process		5
GO:0046872	metal ion binding	Molecular Function		170
GO:0046620	regulation of organ growth	Biological Process		3
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	Biological Process		14
GO:0051301	cell division	Biological Process		58
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IDA[12853976]	26
GO:0000922	spindle pole	Cellular Component	IDA[12853976]	22
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[10871863]	61
GO:0005515	protein binding	Molecular Function	IPI[19739119]	910
GO:0005524	ATP binding	Molecular Function	IDA[10871863]	228
GO:0005634	nucleus	Cellular Component	IDA[10673337]; NAS[10673337]	770
GO:0005815	microtubule organizing center	Cellular Component		19
GO:0005829	cytosol	Cellular Component		447
GO:0006468	protein phosphorylation	Biological Process	IDA[10871863]	53
GO:0007067	mitosis	Biological Process		39
GO:0007243	intracellular protein kinase cascade	Biological Process	IDA[10871863]	19
GO:0009755	hormone-mediated signaling pathway	Biological Process	IDA[15131260]	4

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LATS2 (count: 44)

Gene Symbol	Pathway Count	Pathway List
LATS1	14	keratinocyte differentiation; negative regulation of cyclin-dependent protein kinase activity; hippo signaling cascade; negative regulation of canonical Wnt receptor signaling pathway; cell division; spindle pole; protein serine/threonine kinase activity; protein binding; ATP binding; microtubule organizing center; cytosol; protein phosphorylation; mitosis; hormone-mediated signaling pathway;
PLK1	9	negative regulation of cyclin-dependent protein kinase activity; spindle pole; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; cytosol; protein phosphorylation; mitosis;
NEK6	8	spindle pole; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; microtubule organizing center; protein phosphorylation; mitosis;
CSNK1E	7	cellular protein localization; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; cytosol; protein phosphorylation;
PRKD1	7	metal ion binding; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; cytosol; intracellular protein kinase cascade;
ROCK2	7	metal ion binding; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; cytosol; protein phosphorylation;
GSK3B	7	negative regulation of canonical Wnt receptor signaling pathway; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; cytosol; protein phosphorylation;
PRKAA1	6	metal ion binding; protein binding; ATP binding; nucleus; cytosol; protein phosphorylation;
SMG1	6	metal ion binding; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; cytosol;
BIRC6	6	cell division; spindle pole; protein binding; microtubule organizing center; protein phosphorylation; mitosis;
KIF2C	6	cell division; protein binding; ATP binding; nucleus; cytosol; mitosis;
SMC3	6	cell division; spindle pole; protein binding; ATP binding; nucleus; mitosis;
MAPK1	6	protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; microtubule organizing center; cytosol;
MARK2	6	protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; protein phosphorylation; intracellular protein kinase cascade;
PRKCB	6	protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; cytosol; protein phosphorylation;
RPS6KA4	6	protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; protein phosphorylation; intracellular protein kinase cascade;
SIK2	6	protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; protein phosphorylation; intracellular protein kinase cascade;
CTNND1	5	keratinocyte differentiation; negative regulation of canonical Wnt receptor signaling pathway; protein binding; nucleus; cytosol;
YAP1	5	keratinocyte differentiation; hippo signaling cascade; protein binding; nucleus; cytosol;
APC	5	negative regulation of cyclin-dependent protein kinase activity; negative regulation of canonical Wnt receptor signaling pathway; protein binding; nucleus; cytosol;
BMPR1B	5	metal ion binding; protein serine/threonine kinase activity; protein binding; ATP binding; protein phosphorylation;
PPP1CA	5	metal ion binding; cell division; protein binding; nucleus; cytosol;
TGFBR1	5	metal ion binding; protein serine/threonine kinase activity; protein binding; ATP binding; protein phosphorylation;
CCND1	5	cell division; G1/S transition of mitotic cell cycle; protein binding; nucleus; cytosol;
CDC25B	5	cell division; spindle pole; cytosol; protein phosphorylation; mitosis;
CDCA5	5	cell division; G1/S transition of mitotic cell cycle; protein binding; nucleus; mitosis;
CEP164	5	cell division; protein binding; nucleus; cytosol; mitosis;
KIF11	5	cell division; spindle pole; ATP binding; cytosol; mitosis;
NUMA1	5	cell division; spindle pole; protein binding; nucleus; cytosol;
PTTG1	5	cell division; protein binding; nucleus; cytosol; mitosis;
RBBP8	5	cell division; G1/S transition of mitotic cell cycle; protein binding; nucleus; mitosis;
RCC1	5	cell division; G1/S transition of mitotic cell cycle; protein binding; nucleus; mitosis;
USP37	5	cell division; G1/S transition of mitotic cell cycle; protein binding; nucleus; mitosis;
ZW10	5	cell division; spindle pole; protein binding; nucleus; cytosol;
PSMC3	5	G1/S transition of mitotic cell cycle; protein binding; ATP binding; nucleus; cytosol;
TUBGCP2	5	spindle pole; protein binding; nucleus; microtubule organizing center; cytosol;
CHEK1	5	protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; cytosol;
ILK	5	protein serine/threonine kinase activity; protein binding; ATP binding; cytosol; protein phosphorylation;
MAP4K2	5	protein serine/threonine kinase activity; protein binding; ATP binding; protein phosphorylation; intracellular protein kinase cascade;
MARK4	5	protein serine/threonine kinase activity; protein binding; ATP binding; microtubule organizing center; protein phosphorylation;
PAK1	5	protein serine/threonine kinase activity; protein binding; ATP binding; cytosol; protein phosphorylation;
STK36	5	protein serine/threonine kinase activity; protein binding; ATP binding; nucleus; protein phosphorylation;
FYB	5	protein binding; nucleus; cytosol; protein phosphorylation; intracellular protein kinase cascade;
MAPK3	5	protein binding; ATP binding; nucleus; cytosol; protein phosphorylation;

Genes shared at least 2 KEGG pathways with LATS2 (count: 0)

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Region: chr13:21547171..21635722 View in gBrowse