ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MARK4
Previous Symbol	MARKL1
Symbol Alias	Nbla00650, FLJ90097, KIAA1860
Approved Name	MAP/microtubule affinity-regulating kinase 4
Previous Name	MAP/microtubule affinity-regulating kinase like 1
Location	19q13.2
Position	chr19:45754550-45808541, +
External Links	HGNC: 13538 Entrez Gene: 57787 Ensembl: ENSG00000007047 UCSC: uc002pba.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process	IMP[14594945]	39

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006468	protein phosphorylation	Biological Process	TAS[14594945]	53
GO:0005815	microtubule organizing center	Cellular Component	IDA[14594945]	19
GO:0008017	microtubule binding	Molecular Function	IDA[14594945]	32
GO:0007399	nervous system development	Biological Process	IDA[14594945]	54
GO:0005515	protein binding	Molecular Function	IPI[16959763]	910
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[15009667]	61
GO:0005813	centrosome	Cellular Component	IDA[14594945]	71
GO:0005524	ATP binding	Molecular Function	NAS[15009667]	228
GO:0050321	tau-protein kinase activity	Molecular Function	IDA[14594945]	5
GO:0043130	ubiquitin binding	Molecular Function	NAS[14594945]	9
GO:0043005	neuron projection	Cellular Component	IDA[14594945]	35
GO:0015630	microtubule cytoskeleton	Cellular Component	IDA[14594945]	34
GO:0043068	positive regulation of programmed cell death	Biological Process	NAS[15009667]	1
GO:0043015	gamma-tubulin binding	Molecular Function	IDA[14594945]	5
GO:0001578	microtubule bundle formation	Biological Process	IEP[14594945]	8

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MARK4 (count: 16)

Gene Symbol	Pathway Count	Pathway List
PLK1	7	protein phosphorylation; microtubule binding; protein binding; protein serine/threonine kinase activity; centrosome; ATP binding; microtubule bundle formation;
GSK3B	6	protein phosphorylation; protein binding; protein serine/threonine kinase activity; centrosome; ATP binding; tau-protein kinase activity;
CDC42BPG	5	protein phosphorylation; protein binding; protein serine/threonine kinase activity; centrosome; ATP binding;
LATS1	5	protein phosphorylation; microtubule organizing center; protein binding; protein serine/threonine kinase activity; ATP binding;
LATS2	5	protein phosphorylation; microtubule organizing center; protein binding; protein serine/threonine kinase activity; ATP binding;
MAP3K11	5	protein phosphorylation; protein binding; protein serine/threonine kinase activity; centrosome; ATP binding;
MARK2	5	protein phosphorylation; protein binding; protein serine/threonine kinase activity; ATP binding; tau-protein kinase activity;
NEK6	5	protein phosphorylation; microtubule organizing center; protein binding; protein serine/threonine kinase activity; ATP binding;
ROCK2	5	protein phosphorylation; protein binding; protein serine/threonine kinase activity; centrosome; ATP binding;
MAPK1	5	microtubule organizing center; protein binding; protein serine/threonine kinase activity; ATP binding; microtubule cytoskeleton;
CDK5RAP2	5	microtubule binding; protein binding; centrosome; microtubule cytoskeleton organization; microtubule bundle formation;
CEP57	5	microtubule binding; protein binding; centrosome; microtubule cytoskeleton; gamma-tubulin binding;
CLASP1	5	microtubule binding; protein binding; centrosome; microtubule cytoskeleton organization; microtubule bundle formation;
KIF23	5	microtubule binding; protein binding; centrosome; ATP binding; microtubule cytoskeleton organization;
MAP1S	5	microtubule binding; nervous system development; protein binding; microtubule cytoskeleton organization; microtubule bundle formation;
FEZ1	5	nervous system development; protein binding; centrosome; microtubule cytoskeleton; gamma-tubulin binding;

Genes shared at least 2 KEGG pathways with MARK4 (count: 0)

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Region: chr19:45754550..45808541 View in gBrowse