ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	KIF23
Previous Symbol	KNSL5
Symbol Alias	MKLP1, MKLP-1
Approved Name	kinesin family member 23
Previous Name	kinesin-like 5 (mitotic kinesin-like protein 1)
Location	15q23
Position	chr15:69706688-69745160, +
External Links	HGNC: 6392 Entrez Gene: 9493 Ensembl: ENSG00000137807 UCSC: uc002asb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0000910	cytokinesis	Biological Process		15
GO:0003777	microtubule motor activity	Molecular Function		17
GO:0000022	mitotic spindle elongation	Biological Process	TAS[1406973]	2
GO:0000087	M phase of mitotic cell cycle	Biological Process		19
GO:0005813	centrosome	Cellular Component		71
GO:0005819	spindle	Cellular Component	IDA[15197175]	29
GO:0005829	cytosol	Cellular Component		447
GO:0005871	kinesin complex	Cellular Component	TAS[1406973]	5
GO:0005515	protein binding	Molecular Function	IPI[18329369]	910
GO:0005524	ATP binding	Molecular Function		228
GO:0005634	nucleus	Cellular Component	IDA[11782313]	770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0030496	midbody	Cellular Component		14
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Biological Process		14
GO:0045171	intercellular bridge	Cellular Component		1
GO:0033205	cell cycle cytokinesis	Biological Process	IMP[16236794]	1
GO:0007018	microtubule-based movement	Biological Process		20
GO:0005874	microtubule	Cellular Component		52
GO:0008017	microtubule binding	Molecular Function	IDA[11782313]	32
GO:0007596	blood coagulation	Biological Process		83
GO:0071777	positive regulation of cell cycle cytokinesis	Biological Process	IMP[16103226]	3
GO:0051256	spindle midzone assembly involved in mitosis	Biological Process	IMP[16103226]	2
GO:0097149	centralspindlin complex	Cellular Component	IDA[11782313]	1
GO:0072686	mitotic spindle	Cellular Component	IDA[16236794]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with KIF23 (count: 59)

Gene Symbol	Pathway Count	Pathway List
KIF2C	12	microtubule cytoskeleton organization; mitotic cell cycle; microtubule motor activity; M phase of mitotic cell cycle; cytosol; kinesin complex; protein binding; ATP binding; nucleus; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based movement; blood coagulation;
PLK1	12	mitotic cell cycle; cytokinesis; M phase of mitotic cell cycle; centrosome; spindle; cytosol; protein binding; ATP binding; nucleus; nucleoplasm; midbody; microtubule binding;
KIF11	11	microtubule cytoskeleton organization; microtubule motor activity; spindle; cytosol; kinesin complex; ATP binding; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based movement; microtubule; microtubule binding; blood coagulation;
PAFAH1B1	9	microtubule cytoskeleton organization; mitotic cell cycle; M phase of mitotic cell cycle; centrosome; cytosol; kinesin complex; protein binding; nucleus; microtubule binding;
KIF22	9	microtubule motor activity; spindle; cytosol; ATP binding; nucleus; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based movement; microtubule; blood coagulation;
MAPRE1	8	microtubule cytoskeleton organization; mitotic cell cycle; M phase of mitotic cell cycle; centrosome; spindle; cytosol; protein binding; microtubule;
SMC1A	8	microtubule cytoskeleton organization; mitotic cell cycle; microtubule motor activity; M phase of mitotic cell cycle; protein binding; ATP binding; nucleus; nucleoplasm;
SMC3	8	microtubule cytoskeleton organization; mitotic cell cycle; microtubule motor activity; M phase of mitotic cell cycle; protein binding; ATP binding; nucleus; nucleoplasm;
DCTN3	8	mitotic cell cycle; cytokinesis; centrosome; spindle; cytosol; protein binding; midbody; antigen processing and presentation of exogenous peptide antigen via MHC class II;
INCENP	8	mitotic cell cycle; cytokinesis; M phase of mitotic cell cycle; spindle; cytosol; protein binding; midbody; microtubule;
KLC2	8	microtubule motor activity; cytosol; kinesin complex; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based movement; microtubule; blood coagulation;
CDK5RAP2	7	microtubule cytoskeleton organization; mitotic cell cycle; centrosome; cytosol; protein binding; microtubule; microtubule binding;
CLASP1	7	microtubule cytoskeleton organization; mitotic cell cycle; M phase of mitotic cell cycle; centrosome; cytosol; protein binding; microtubule binding;
MAP1S	7	microtubule cytoskeleton organization; spindle; cytosol; protein binding; nucleus; microtubule; microtubule binding;
PRC1	7	microtubule cytoskeleton organization; cytokinesis; mitotic spindle elongation; spindle; protein binding; nucleus; microtubule binding;
CEP57	7	mitotic cell cycle; centrosome; cytosol; protein binding; nucleus; microtubule; microtubule binding;
NDE1	7	mitotic cell cycle; M phase of mitotic cell cycle; centrosome; cytosol; protein binding; microtubule; microtubule binding;
AURKC	7	cytokinesis; spindle; ATP binding; nucleus; midbody; positive regulation of cell cycle cytokinesis; spindle midzone assembly involved in mitosis;
KIFC1	7	microtubule motor activity; spindle; ATP binding; nucleus; microtubule-based movement; microtubule; blood coagulation;
MAPK1	7	spindle; cytosol; protein binding; ATP binding; nucleus; nucleoplasm; blood coagulation;
APC	6	microtubule cytoskeleton organization; centrosome; cytosol; protein binding; nucleus; microtubule binding;
ARHGEF2	6	microtubule cytoskeleton organization; spindle; cytosol; protein binding; microtubule; microtubule binding;
CENPJ	6	microtubule cytoskeleton organization; mitotic cell cycle; centrosome; cytosol; protein binding; microtubule;
CKAP5	6	microtubule cytoskeleton organization; mitotic cell cycle; M phase of mitotic cell cycle; centrosome; cytosol; protein binding;
CLASP2	6	microtubule cytoskeleton organization; mitotic cell cycle; M phase of mitotic cell cycle; cytosol; protein binding; microtubule;
TUBGCP2	6	microtubule cytoskeleton organization; mitotic cell cycle; centrosome; cytosol; protein binding; nucleus;
TUBGCP5	6	microtubule cytoskeleton organization; mitotic cell cycle; centrosome; cytosol; microtubule; microtubule binding;
TUBGCP6	6	microtubule cytoskeleton organization; mitotic cell cycle; centrosome; cytosol; microtubule; microtubule binding;
NUMA1	6	mitotic cell cycle; spindle; cytosol; protein binding; nucleus; nucleoplasm;
PSMC3	6	mitotic cell cycle; cytosol; protein binding; ATP binding; nucleus; nucleoplasm;
ROCK2	6	cytokinesis; centrosome; cytosol; protein binding; ATP binding; nucleus;
DYNC2H1	6	microtubule motor activity; cytosol; ATP binding; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based movement; microtubule;
CHEK1	6	centrosome; cytosol; protein binding; ATP binding; nucleus; nucleoplasm;
MAPK3	6	cytosol; protein binding; ATP binding; nucleus; nucleoplasm; blood coagulation;
HOOK3	5	microtubule cytoskeleton organization; centrosome; protein binding; microtubule; microtubule binding;
KATNB1	5	microtubule cytoskeleton organization; centrosome; midbody; microtubule; microtubule binding;
MAPT	5	microtubule cytoskeleton organization; cytosol; protein binding; microtubule; microtubule binding;
MARK4	5	microtubule cytoskeleton organization; centrosome; protein binding; ATP binding; microtubule binding;
TPPP	5	microtubule cytoskeleton organization; protein binding; nucleus; microtubule; microtubule binding;
TUBG1	5	microtubule cytoskeleton organization; mitotic cell cycle; centrosome; cytosol; protein binding;
UXT	5	microtubule cytoskeleton organization; centrosome; protein binding; nucleus; microtubule binding;
CCND1	5	mitotic cell cycle; cytosol; protein binding; nucleus; nucleoplasm;
CDC25B	5	mitotic cell cycle; centrosome; cytosol; nucleoplasm; positive regulation of cell cycle cytokinesis;
CDC45	5	mitotic cell cycle; centrosome; protein binding; nucleus; nucleoplasm;
CDT1	5	mitotic cell cycle; cytosol; protein binding; nucleus; nucleoplasm;
CEP164	5	mitotic cell cycle; centrosome; cytosol; protein binding; nucleus;
CSNK1E	5	mitotic cell cycle; cytosol; protein binding; ATP binding; nucleus;
TUBA4A	5	mitotic cell cycle; cytosol; microtubule-based movement; microtubule; blood coagulation;
XPO1	5	mitotic cell cycle; M phase of mitotic cell cycle; cytosol; protein binding; nucleoplasm;
ZW10	5	mitotic cell cycle; M phase of mitotic cell cycle; cytosol; protein binding; nucleus;
NEK6	5	cytokinesis; protein binding; ATP binding; nucleus; microtubule;
PIK3C3	5	cytokinesis; cytosol; protein binding; ATP binding; midbody;
DHX9	5	centrosome; protein binding; ATP binding; nucleus; nucleoplasm;
GSK3B	5	centrosome; cytosol; protein binding; ATP binding; nucleus;
RFWD2	5	centrosome; cytosol; protein binding; nucleus; nucleoplasm;
PSRC1	5	spindle; cytosol; protein binding; midbody; microtubule binding;
MAPK7	5	cytosol; protein binding; ATP binding; nucleus; nucleoplasm;
PRKCB	5	cytosol; protein binding; ATP binding; nucleus; blood coagulation;
HSPA5	5	protein binding; ATP binding; nucleus; midbody; blood coagulation;

Genes shared at least 2 KEGG pathways with KIF23 (count: 0)

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Region: chr15:69706688..69745160 View in gBrowse