ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PRC1
Symbol Alias	ASE1
Approved Name	protein regulator of cytokinesis 1
Name Alias	anaphase spindle elongation 1 homolog (S. cerevisiae)
Location	15q26.1
Position	chr15:91509268-91537804, -
External Links	HGNC: 9341 Entrez Gene: 9055 Ensembl: ENSG00000198901 UCSC: uc002bqm.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008017	microtubule binding	Molecular Function		32
GO:0005886	plasma membrane	Cellular Component		772
GO:0019901	protein kinase binding	Molecular Function	IPI[17351640]	51
GO:0015630	microtubule cytoskeleton	Cellular Component		34
GO:0005737	cytoplasm	Cellular Component		690
GO:0005730	nucleolus	Cellular Component		243
GO:0005876	spindle microtubule	Cellular Component	TAS[9885575]	9
GO:0005819	spindle	Cellular Component	IDA[17351640]	29
GO:0000922	spindle pole	Cellular Component		22
GO:0000910	cytokinesis	Biological Process	IDA[17351640]	15
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[19447967]	910
GO:0000022	mitotic spindle elongation	Biological Process	TAS[9885575]	2
GO:0042802	identical protein binding	Molecular Function		70

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PRC1 (count: 47)

Gene Symbol	Pathway Count	Pathway List
PLK1	8	microtubule binding; protein kinase binding; spindle microtubule; spindle; spindle pole; cytokinesis; nucleus; protein binding;
APC	7	microtubule binding; plasma membrane; protein kinase binding; cytoplasm; nucleus; protein binding; microtubule cytoskeleton organization;
KIF11	7	microtubule binding; protein kinase binding; cytoplasm; spindle microtubule; spindle; spindle pole; microtubule cytoskeleton organization;
KIF23	7	microtubule binding; spindle; cytokinesis; nucleus; protein binding; microtubule cytoskeleton organization; mitotic spindle elongation;
PSRC1	7	microtubule binding; microtubule cytoskeleton; cytoplasm; spindle microtubule; spindle; spindle pole; protein binding;
NUMA1	7	cytoplasm; nucleolus; spindle microtubule; spindle; spindle pole; nucleus; protein binding;
CDK5RAP2	6	microtubule binding; protein kinase binding; cytoplasm; spindle pole; protein binding; microtubule cytoskeleton organization;
CEP57	6	microtubule binding; microtubule cytoskeleton; cytoplasm; nucleolus; nucleus; protein binding;
CRYAB	6	microtubule binding; plasma membrane; microtubule cytoskeleton; cytoplasm; nucleus; protein binding;
KATNB1	6	microtubule binding; plasma membrane; microtubule cytoskeleton; cytoplasm; spindle pole; microtubule cytoskeleton organization;
MAP1S	6	microtubule binding; spindle; nucleus; protein binding; microtubule cytoskeleton organization; identical protein binding;
NUSAP1	6	microtubule binding; cytoplasm; nucleolus; spindle microtubule; nucleus; microtubule cytoskeleton organization;
PAFAH1B1	6	microtubule binding; cytoplasm; nucleolus; nucleus; protein binding; microtubule cytoskeleton organization;
SNCA	6	microtubule binding; plasma membrane; cytoplasm; nucleus; protein binding; identical protein binding;
TPPP	6	microtubule binding; plasma membrane; cytoplasm; nucleus; protein binding; microtubule cytoskeleton organization;
BAIAP2	6	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding; identical protein binding;
GSK3B	6	plasma membrane; protein kinase binding; cytoplasm; nucleolus; nucleus; protein binding;
NEK6	6	protein kinase binding; cytoplasm; spindle pole; cytokinesis; nucleus; protein binding;
MAPK1	6	microtubule cytoskeleton; cytoplasm; nucleolus; spindle; nucleus; protein binding;
HOOK3	5	microtubule binding; cytoplasm; protein binding; microtubule cytoskeleton organization; identical protein binding;
MAPT	5	microtubule binding; plasma membrane; protein kinase binding; protein binding; microtubule cytoskeleton organization;
UXT	5	microtubule binding; cytoplasm; nucleus; protein binding; microtubule cytoskeleton organization;
AIP	5	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding;
CDCA5	5	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding;
CHD1L	5	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding;
COG3	5	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding;
MALT1	5	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding;
NF2	5	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding;
PAK1	5	plasma membrane; protein kinase binding; cytoplasm; protein binding; identical protein binding;
PPP4C	5	plasma membrane; cytoplasm; nucleus; protein binding; microtubule cytoskeleton organization;
PRKD1	5	plasma membrane; cytoplasm; nucleus; protein binding; identical protein binding;
RNF40	5	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding;
RRP8	5	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding;
SAP18	5	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding;
STXBP3	5	plasma membrane; cytoplasm; nucleolus; nucleus; protein binding;
RAD9A	5	protein kinase binding; cytoplasm; nucleolus; nucleus; protein binding;
RELA	5	protein kinase binding; cytoplasm; nucleus; protein binding; identical protein binding;
ALKBH8	5	microtubule cytoskeleton; cytoplasm; nucleolus; nucleus; protein binding;
DGCR8	5	microtubule cytoskeleton; cytoplasm; nucleolus; nucleus; protein binding;
ATXN1	5	cytoplasm; nucleolus; nucleus; protein binding; identical protein binding;
GPSM2	5	cytoplasm; nucleolus; nucleus; protein binding; identical protein binding;
PRPF19	5	cytoplasm; spindle; nucleus; protein binding; identical protein binding;
RCC1	5	cytoplasm; nucleolus; nucleus; protein binding; microtubule cytoskeleton organization;
SMC1A	5	cytoplasm; nucleolus; nucleus; protein binding; microtubule cytoskeleton organization;
SMC3	5	cytoplasm; spindle pole; nucleus; protein binding; microtubule cytoskeleton organization;
TRIM5	5	cytoplasm; nucleolus; nucleus; protein binding; identical protein binding;
TUBGCP2	5	nucleolus; spindle pole; nucleus; protein binding; microtubule cytoskeleton organization;

Genes shared at least 2 KEGG pathways with PRC1 (count: 0)

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Region: chr15:91509268..91537804 View in gBrowse