ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CRYAB
Previous Symbol	CRYA2
Symbol Alias	HSPB5
Approved Name	crystallin, alpha B
Location	11q22.3-q23.1
Position	chr11:111779289-111794446, -1
External Links	HGNC: 2389 Entrez Gene: 1410 UCSC: uc001pmf.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 36)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 36)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042542	response to hydrogen peroxide	biological process	IEA	7
GO:0060561	apoptotic process involved in morphogenesis	biological process	IEA	2
GO:0006936	muscle contraction	biological process	TAS[9731540]	18
GO:0005739	mitochondrion	cellular component	IEA	221
GO:0051403	stress-activated MAPK cascade	biological process	IEA	10
GO:0042803	protein homodimerization activity	molecular function	IPI[19646995]	128
GO:0032432	actin filament bundle	cellular component	IEA	2
GO:0030018	Z disc	cellular component	IEA	17
GO:0008017	microtubule binding	molecular function	IEA	34
GO:0002088	lens development in camera-type eye	biological process	IEA	7
GO:0046872	metal ion binding	molecular function	IEA	200
GO:2000378	negative regulation of reactive oxygen species metabolic process	biological process	IEA	3
GO:0005634	nucleus	cellular component	IDA[19464326]	877
GO:0001666	response to hypoxia	biological process	IEA	41
GO:0030308	negative regulation of cell growth	biological process	IEA	23
GO:0006006	glucose metabolic process	biological process	IEA	20
GO:0032387	negative regulation of intracellular transport	biological process	IDA[14752512]	3
GO:0006457	protein folding	biological process	IEA	33
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IEA	12
GO:0005212	structural constituent of eye lens	molecular function	IEA	5
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0007517	muscle organ development	biological process	IEA	17
GO:0005829	cytosol	cellular component	IEA	485
GO:0031109	microtubule polymerization or depolymerization	biological process	IEA	1
GO:0015630	microtubule cytoskeleton	cellular component	IEA	35
GO:0051082	unfolded protein binding	molecular function	IPI[16303126]	23
GO:0043066	negative regulation of apoptotic process	biological process	IDA[14752512]	85
GO:0005886	plasma membrane	cellular component	IEA	839
GO:0010629	negative regulation of gene expression	biological process	IEA	13
GO:0009986	cell surface	cellular component	IEA	75
GO:0005794	Golgi apparatus	cellular component	IEA	174
GO:0032355	response to estradiol stimulus	biological process	IEA	19
GO:0051260	protein homooligomerization	biological process	IDA[16303126]	38
GO:0007021	tubulin complex assembly	biological process	IEA	2
GO:0007568	aging	biological process	IEA	29
GO:0005515	protein binding	molecular function	IPI[16225851]	1015

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CRYAB (count: 122)

Gene Symbol	Pathway Count	Pathway List
SNCA	11	mitochondrion; microtubule binding; nucleus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; cytosol; negative regulation of apoptotic process; plasma membrane; Golgi apparatus; aging; protein binding;
CEP57	9	protein homodimerization activity; microtubule binding; nucleus; cytoplasm; cytosol; microtubule cytoskeleton; Golgi apparatus; protein homooligomerization; protein binding;
DNAJA3	9	metal ion binding; nucleus; protein folding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; cytosol; unfolded protein binding; negative regulation of apoptotic process; protein binding;
MAPK1	8	mitochondrion; stress-activated MAPK cascade; nucleus; cytoplasm; cytosol; microtubule cytoskeleton; Golgi apparatus; protein binding;
PDE2A	8	protein homodimerization activity; metal ion binding; nucleus; cytoplasm; cytosol; plasma membrane; Golgi apparatus; protein binding;
TSC2	8	protein homodimerization activity; nucleus; response to hypoxia; cytoplasm; cytosol; Golgi apparatus; protein homooligomerization; protein binding;
RELA	7	response to hydrogen peroxide; nucleus; cytoplasm; cytosol; negative regulation of apoptotic process; aging; protein binding;
BNIP3	7	mitochondrion; protein homodimerization activity; nucleus; response to hypoxia; cytoplasm; negative regulation of apoptotic process; protein binding;
MAPK3	7	mitochondrion; stress-activated MAPK cascade; nucleus; cytosol; microtubule cytoskeleton; Golgi apparatus; protein binding;
WWOX	7	mitochondrion; nucleus; cytoplasm; cytosol; plasma membrane; Golgi apparatus; protein binding;
GHR	7	mitochondrion; protein homodimerization activity; nucleus; plasma membrane; cell surface; response to estradiol stimulus; protein binding;
TH	7	mitochondrion; nucleus; response to hypoxia; cytoplasm; cytosol; response to estradiol stimulus; protein binding;
KARS	7	mitochondrion; metal ion binding; nucleus; cytoplasm; cytosol; microtubule cytoskeleton; plasma membrane;
AXIN1	7	protein homodimerization activity; nucleus; cytoplasm; cytosol; plasma membrane; protein homooligomerization; protein binding;
SLC6A4	7	protein homodimerization activity; response to hypoxia; cytosol; plasma membrane; response to estradiol stimulus; protein homooligomerization; protein binding;
VEGFA	7	protein homodimerization activity; response to hypoxia; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; negative regulation of apoptotic process; cell surface; protein binding;
ACHE	7	protein homodimerization activity; nucleus; muscle organ development; plasma membrane; cell surface; Golgi apparatus; protein binding;
PAK1	7	Z disc; response to hypoxia; cytoplasm; cytosol; plasma membrane; Golgi apparatus; protein binding;
APC	7	microtubule binding; nucleus; cytoplasm; cytosol; negative regulation of apoptotic process; plasma membrane; protein binding;
PRKD1	7	metal ion binding; nucleus; cytoplasm; cytosol; plasma membrane; Golgi apparatus; protein binding;
PRKAA1	7	metal ion binding; nucleus; response to hypoxia; glucose metabolic process; cytosol; negative regulation of apoptotic process; protein binding;
HSPA8	7	nucleus; protein folding; cytosol; unfolded protein binding; plasma membrane; cell surface; protein binding;
INPPL1	7	glucose metabolic process; cytoplasm; cytosol; plasma membrane; negative regulation of gene expression; Golgi apparatus; protein binding;
GSTP1	6	mitochondrion; nucleus; cytoplasm; cytosol; negative regulation of apoptotic process; protein binding;
PARK2	6	mitochondrion; nucleus; cytoplasm; cytosol; Golgi apparatus; protein binding;
PYCARD	6	mitochondrion; protein homodimerization activity; nucleus; cytoplasm; cytosol; protein binding;
IREB2	6	mitochondrion; metal ion binding; cytoplasm; cytosol; aging; protein binding;
STK11	6	mitochondrion; nucleus; negative regulation of cell growth; cytoplasm; cytosol; protein binding;
PICK1	6	mitochondrion; metal ion binding; cytoplasm; plasma membrane; Golgi apparatus; protein binding;
AIFM3	6	mitochondrion; metal ion binding; nucleus; cytoplasm; cytosol; plasma membrane;
GOPC	6	protein homodimerization activity; cytoplasm; plasma membrane; Golgi apparatus; protein homooligomerization; protein binding;
TFAP2B	6	protein homodimerization activity; nucleus; glucose metabolic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; protein binding;
PAFAH1B1	6	protein homodimerization activity; microtubule binding; nucleus; cytoplasm; cytosol; protein binding;
ENPP1	6	protein homodimerization activity; metal ion binding; negative regulation of cell growth; plasma membrane; cell surface; protein binding;
PRC1	6	microtubule binding; nucleus; cytoplasm; microtubule cytoskeleton; plasma membrane; protein binding;
UXT	6	microtubule binding; nucleus; protein folding; cytoplasm; unfolded protein binding; protein binding;
PSRC1	6	microtubule binding; negative regulation of cell growth; cytoplasm; cytosol; microtubule cytoskeleton; protein binding;
ALKBH8	6	metal ion binding; nucleus; cytoplasm; cytosol; microtubule cytoskeleton; protein binding;
FBP1	6	metal ion binding; negative regulation of cell growth; glucose metabolic process; cytoplasm; cytosol; protein binding;
MAP2K5	6	metal ion binding; nucleus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cytosol; negative regulation of apoptotic process; protein binding;
AATF	6	negative regulation of reactive oxygen species metabolic process; nucleus; cytoplasm; negative regulation of apoptotic process; Golgi apparatus; protein binding;
GSK3B	6	nucleus; cytoplasm; cytosol; negative regulation of apoptotic process; plasma membrane; protein binding;
MALT1	6	nucleus; cytoplasm; cytosol; negative regulation of apoptotic process; plasma membrane; protein binding;
CBL	6	nucleus; cytoplasm; cytosol; negative regulation of apoptotic process; plasma membrane; protein binding;
STRN3	6	nucleus; cytoplasm; plasma membrane; Golgi apparatus; response to estradiol stimulus; protein binding;
KLHL20	6	nucleus; cytoplasm; negative regulation of apoptotic process; cell surface; Golgi apparatus; protein binding;
AIP	6	nucleus; cytoplasm; cytosol; unfolded protein binding; plasma membrane; protein binding;
TNFAIP3	6	nucleus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; cytosol; negative regulation of apoptotic process; protein binding;
FLCN	6	nucleus; negative regulation of cell growth; cytoplasm; plasma membrane; negative regulation of gene expression; protein binding;
BAD	5	response to hydrogen peroxide; mitochondrion; cytosol; response to estradiol stimulus; protein binding;
GNAO1	5	response to hydrogen peroxide; muscle contraction; metal ion binding; plasma membrane; aging;
PRDX5	5	mitochondrion; nucleus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; negative regulation of apoptotic process;
MAD1L1	5	mitochondrion; nucleus; cytoplasm; cytosol; protein binding;
SHMT1	5	mitochondrion; protein homodimerization activity; nucleus; cytoplasm; cytosol;
GOLPH3	5	mitochondrion; cytoplasm; cytosol; plasma membrane; protein binding;
SOD3	5	mitochondrion; nucleus; response to hypoxia; cytosol; protein binding;
PTS	5	mitochondrion; protein homodimerization activity; metal ion binding; cytoplasm; cytosol;
DCPS	5	mitochondrion; nucleus; cytoplasm; cytosol; protein binding;
PERP	5	mitochondrion; nucleus; cytoplasm; plasma membrane; Golgi apparatus;
RIPK3	5	mitochondrion; cytosol; plasma membrane; protein homooligomerization; protein binding;
CRYM	5	mitochondrion; protein homodimerization activity; nucleus; cytoplasm; plasma membrane;
MAPK7	5	stress-activated MAPK cascade; nucleus; cytosol; negative regulation of apoptotic process; protein binding;
HMGCS1	5	protein homodimerization activity; nucleus; cytoplasm; cytosol; plasma membrane;
TERT	5	protein homodimerization activity; metal ion binding; cytoplasm; negative regulation of apoptotic process; protein binding;
CCDC88A	5	protein homodimerization activity; microtubule binding; cytosol; plasma membrane; Golgi apparatus;
FZD4	5	protein homodimerization activity; cytoplasm; plasma membrane; cell surface; protein binding;
PDCD10	5	protein homodimerization activity; cytosol; negative regulation of apoptotic process; plasma membrane; protein binding;
DAXX	5	protein homodimerization activity; nucleus; cytoplasm; cytosol; protein binding;
TRIM5	5	protein homodimerization activity; nucleus; cytoplasm; Golgi apparatus; protein binding;
PRLR	5	protein homodimerization activity; metal ion binding; negative regulation of apoptotic process; plasma membrane; cell surface;
RNF40	5	protein homodimerization activity; nucleus; cytoplasm; plasma membrane; protein binding;
MTMR2	5	protein homodimerization activity; nucleus; cytoplasm; cytosol; protein binding;
BARD1	5	protein homodimerization activity; nucleus; cytoplasm; negative regulation of apoptotic process; protein binding;
CORO1A	5	protein homodimerization activity; nucleus; cytoplasm; plasma membrane; protein binding;
ADRB3	5	protein homodimerization activity; nucleus; plasma membrane; aging; protein binding;
CACNA1C	5	Z disc; metal ion binding; cytoplasm; plasma membrane; protein binding;
CAV3	5	Z disc; muscle organ development; plasma membrane; cell surface; protein binding;
FLNC	5	Z disc; cytoplasm; cytosol; plasma membrane; protein binding;
ARHGEF2	5	microtubule binding; cytosol; negative regulation of apoptotic process; Golgi apparatus; protein binding;
GABARAPL2	5	microtubule binding; cytoplasm; cytosol; Golgi apparatus; protein binding;
MAPT	5	microtubule binding; negative regulation of intracellular transport; cytosol; plasma membrane; protein binding;
PLK1	5	microtubule binding; nucleus; cytosol; negative regulation of apoptotic process; protein binding;
CDK5RAP2	5	microtubule binding; cytoplasm; cytosol; Golgi apparatus; protein binding;
TPPP	5	microtubule binding; nucleus; cytoplasm; plasma membrane; protein binding;
TGFBR1	5	lens development in camera-type eye; metal ion binding; negative regulation of apoptotic process; plasma membrane; protein binding;
CRYGD	5	lens development in camera-type eye; nucleus; structural constituent of eye lens; cytoplasm; protein binding;
PPP1CA	5	metal ion binding; nucleus; cytoplasm; cytosol; protein binding;
SMG1	5	metal ion binding; nucleus; cytoplasm; cytosol; protein binding;
PARN	5	metal ion binding; nucleus; cytoplasm; cytosol; protein binding;
CACNA1A	5	metal ion binding; nucleus; cytoplasm; plasma membrane; protein binding;
ROCK2	5	metal ion binding; nucleus; cytosol; plasma membrane; protein binding;
NUBP1	5	metal ion binding; cytoplasm; cytosol; plasma membrane; protein binding;
DGCR8	5	metal ion binding; nucleus; cytoplasm; microtubule cytoskeleton; protein binding;
PPP4C	5	metal ion binding; nucleus; cytoplasm; plasma membrane; protein binding;
BIRC3	5	negative regulation of reactive oxygen species metabolic process; nucleus; cytoplasm; negative regulation of apoptotic process; protein binding;
EHD3	5	nucleus; cytoplasm; plasma membrane; protein homooligomerization; protein binding;
FGF10	5	nucleus; negative regulation of apoptotic process; plasma membrane; cell surface; response to estradiol stimulus;
TJP1	5	nucleus; cytoplasm; cytosol; plasma membrane; protein binding;
ARRB1	5	nucleus; cytoplasm; cytosol; plasma membrane; protein binding;
SART1	5	nucleus; cytoplasm; cytosol; Golgi apparatus; protein binding;
MGRN1	5	nucleus; cytoplasm; cytosol; plasma membrane; protein binding;
ARRB2	5	nucleus; cytoplasm; cytosol; plasma membrane; protein binding;
ID2	5	nucleus; cytoplasm; cytosol; negative regulation of gene expression; protein binding;
ADRB1	5	nucleus; cytoplasm; plasma membrane; aging; protein binding;
CTNND1	5	nucleus; cytoplasm; cytosol; plasma membrane; protein binding;
YAP1	5	nucleus; cytoplasm; cytosol; negative regulation of apoptotic process; protein binding;
APBB1	5	nucleus; negative regulation of cell growth; cytoplasm; plasma membrane; protein binding;
STXBP3	5	nucleus; cytoplasm; cytosol; plasma membrane; protein binding;
EGLN3	5	nucleus; response to hypoxia; cytoplasm; cytosol; protein binding;
HSPA5	5	nucleus; unfolded protein binding; negative regulation of apoptotic process; cell surface; protein binding;
SYTL2	5	nucleus; cytoplasm; plasma membrane; Golgi apparatus; protein binding;
NCK1	5	nucleus; cytoplasm; cytosol; plasma membrane; protein binding;
FLT4	5	nucleus; cytoplasm; negative regulation of apoptotic process; plasma membrane; protein binding;
BAIAP2	5	nucleus; cytoplasm; cytosol; plasma membrane; protein binding;
COG3	5	nucleus; cytoplasm; plasma membrane; Golgi apparatus; protein binding;
ADAM17	5	response to hypoxia; cytoplasm; plasma membrane; cell surface; protein binding;
PRKG1	5	cytoplasm; cytosol; plasma membrane; Golgi apparatus; protein binding;
MIF	5	cytoplasm; negative regulation of apoptotic process; negative regulation of gene expression; cell surface; protein binding;
CLASP2	5	cytoplasm; cytosol; plasma membrane; Golgi apparatus; protein binding;
PIK3CG	5	cytoplasm; cytosol; negative regulation of apoptotic process; plasma membrane; protein binding;
SORT1	5	cytoplasm; negative regulation of apoptotic process; plasma membrane; cell surface; Golgi apparatus;
CTGF	5	cytosol; plasma membrane; negative regulation of gene expression; Golgi apparatus; response to estradiol stimulus;

Genes shared at least 2 KEGG pathways with CRYAB (count: 0)

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Region: chr11:111779289..111794446 View in gBrowse