ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FGF10
Approved Name	fibroblast growth factor 10
Location	5p13-p12
Position	chr5:44303646-44389808, -
External Links	HGNC: 3666 Entrez Gene: 2255 Ensembl: ENSG00000070193 UCSC: uc003jog.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Laurin N, 2008(a)	single marker and haplotype analyses yielded little evidence for significant association	Non-significant

Gene related SNPs (count: 69)

Literature-origin SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11743802	Chr5:44351154(Fwd)	intron_variant	1(0/1/0)
rs2290070	Chr5:44305309(Fwd)	intron_variant	1(0/1/0)
rs980510	Chr5:44318532(Fwd)	intron_variant	1(0/1/0)

LD-proxies (count: 66)

rs_ID	Location	Functional Annotation
rs16874036	Chr5:44366552(Fwd)	intron_variant
rs10941664	Chr5:44362134(Fwd)	intron_variant
rs1482689	Chr5:44359428(Fwd)	intron_variant
rs10512845	Chr5:44341336(Fwd)	intron_variant
rs10512844	Chr5:44338759(Fwd)	intron_variant
rs983373	Chr5:44335338(Fwd)	intron_variant
rs987642	Chr5:44331905(Fwd)	intron_variant
rs10473353	Chr5:44315108(Fwd)	intron_variant
rs2973650	Chr5:44392131(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs6891282	Chr5:44388150(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs2973649	Chr5:44391161(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs2973644	Chr5:44384183(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs2973646	Chr5:44387537(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs16901816	Chr5:44381698(Fwd)	intron_variant
rs6892212	Chr5:44382842(Fwd)	intron_variant
rs1374962	Chr5:44311070(Fwd)	intron_variant
rs1448035	Chr5:44311768(Fwd)	intron_variant
rs9292903	Chr5:44299998(Fwd)	downstream_gene_variant
rs13180550	Chr5:44330995(Fwd)	intron_variant
rs12652957	Chr5:44331751(Fwd)	intron_variant
rs13165847	Chr5:44328829(Fwd)	intron_variant
rs17316984	Chr5:44315374(Fwd)	intron_variant
rs13170645	Chr5:44329203(Fwd)	intron_variant
rs10512849	Chr5:44384223(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs6881989	Chr5:44301390(Fwd)	downstream_gene_variant
rs2330545	Chr5:44339810(Fwd)	intron_variant
rs1979079	Chr5:44300650(Fwd)	downstream_gene_variant
rs4866893	Chr5:44339984(Fwd)	intron_variant
rs17234191	Chr5:44347584(Fwd)	intron_variant
rs6451758	Chr5:44305515(Fwd)	intron_variant
rs1011814	Chr5:44335820(Fwd)	intron_variant
rs1823251	Chr5:44303717(Fwd)	3_prime_UTR_variant
rs2330544	Chr5:44339764(Fwd)	intron_variant
rs7708529	Chr5:44347131(Fwd)	intron_variant
rs6881797	Chr5:44310492(Fwd)	intron_variant
rs1448039	Chr5:44349141(Fwd)	intron_variant
rs10473352	Chr5:44308252(Fwd)	intron_variant
rs6451761	Chr5:44341979(Fwd)	intron_variant
rs1816965	Chr5:44322310(Fwd)	intron_variant
rs10073166	Chr5:44345540(Fwd)	intron_variant
rs1816964	Chr5:44313650(Fwd)	intron_variant
rs593307	Chr5:44358915(Fwd)	intron_variant
rs10805683	Chr5:44375270(Fwd)	intron_variant
rs339509	Chr5:44360892(Fwd)	intron_variant
rs735083	Chr5:44334051(Fwd)	intron_variant
rs1448037	Chr5:44352344(Fwd)	intron_variant
rs969520	Chr5:44380206(Fwd)	intron_variant
rs1550937	Chr5:44356347(Fwd)	intron_variant
rs1384449	Chr5:44377060(Fwd)	intron_variant
rs339502	Chr5:44364007(Fwd)	intron_variant
rs2121875	Chr5:44365545(Fwd)	intron_variant
rs1482671	Chr5:44362538(Fwd)	intron_variant
rs1482672	Chr5:44362769(Fwd)	intron_variant
rs900379	Chr5:44369656(Fwd)	intron_variant
rs2170582	Chr5:44371669(Fwd)	intron_variant
rs6859730	Chr5:44367221(Fwd)	intron_variant
rs1482675	Chr5:44368506(Fwd)	intron_variant
rs1482673	Chr5:44368123(Fwd)	intron_variant
rs10072476	Chr5:44299400(Fwd)	downstream_gene_variant
rs11750845	Chr5:44373060(Fwd)	intron_variant
rs1482679	Chr5:44385415(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs1482680	Chr5:44392142(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs4866891	Chr5:44328270(Fwd)	intron_variant
rs1839090	Chr5:44313282(Fwd)	intron_variant
rs1374961	Chr5:44303760(Fwd)	3_prime_UTR_variant
rs10074405	Chr5:44300025(Fwd)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 106)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 106)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042056	chemoattractant activity	Molecular Function	IDA[9740653]	5
GO:0035019	somatic stem cell maintenance	Biological Process		7
GO:0042246	tissue regeneration	Biological Process		4
GO:0042060	wound healing	Biological Process	IDA[19152659]	13
GO:0032808	lacrimal gland development	Biological Process	IMP[17213838]	1
GO:0032781	positive regulation of ATPase activity	Biological Process	IDA[12804770]	3
GO:0034394	protein localization to cell surface	Biological Process	IDA[17449030]	4
GO:0032925	regulation of activin receptor signaling pathway	Biological Process		2
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S	Biological Process	IDA[17188682]	2
GO:0031532	actin cytoskeleton reorganization	Biological Process	IDA[17449030]	5
GO:0032496	response to lipopolysaccharide	Biological Process		22
GO:0032355	response to estradiol stimulus	Biological Process		18
GO:0031016	pancreas development	Biological Process		5
GO:0031012	extracellular matrix	Cellular Component	IDA[17959718]	28
GO:0031076	embryonic camera-type eye development	Biological Process		1
GO:0031069	hair follicle morphogenesis	Biological Process		4
GO:0046877	regulation of saliva secretion	Biological Process	IMP[19102732]	1
GO:0048146	positive regulation of fibroblast proliferation	Biological Process		4
GO:0048536	spleen development	Biological Process		5
GO:0048538	thymus development	Biological Process	IDA[17969154]	14
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[17500053]	80
GO:0045931	positive regulation of mitotic cell cycle	Biological Process		5
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0046579	positive regulation of Ras protein signal transduction	Biological Process	IDA[12804770]	2
GO:0043616	keratinocyte proliferation	Biological Process		4
GO:0045739	positive regulation of DNA repair	Biological Process	IDA[14975937]	4
GO:0045740	positive regulation of DNA replication	Biological Process	IMP[17471512]	7
GO:0045747	positive regulation of Notch signaling pathway	Biological Process		2
GO:0042475	odontogenesis of dentin-containing tooth	Biological Process		8
GO:0042693	muscle cell fate commitment	Biological Process		2
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0043410	positive regulation of MAPK cascade	Biological Process	IDA[12804770]	17
GO:0060019	radial glial cell differentiation	Biological Process		1
GO:0051549	positive regulation of keratinocyte migration	Biological Process	IDA[19152659]	1
GO:0051145	smooth muscle cell differentiation	Biological Process		6
GO:0050930	induction of positive chemotaxis	Biological Process		6
GO:0050918	positive chemotaxis	Biological Process	IDA[9740653]	7
GO:0050872	white fat cell differentiation	Biological Process		2
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process	IDA[17449030]	14
GO:0050679	positive regulation of epithelial cell proliferation	Biological Process	IDA[15690149]	9
GO:0050677	positive regulation of urothelial cell proliferation	Biological Process	IDA[11923311]	1
GO:0050674	urothelial cell proliferation	Biological Process	IDA[11923311]	1
GO:0050673	epithelial cell proliferation	Biological Process	IDA[19224135]	5
GO:0050671	positive regulation of lymphocyte proliferation	Biological Process	IDA[19152659]	2
GO:0048808	male genitalia morphogenesis	Biological Process		1
GO:0048807	female genitalia morphogenesis	Biological Process		1
GO:0048754	branching morphogenesis of a tube	Biological Process	IDA[17959718]	6
GO:0048557	embryonic digestive tract morphogenesis	Biological Process		7
GO:0060685	regulation of prostatic bud formation	Biological Process		1
GO:0060879	semicircular canal fusion	Biological Process		1
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	Biological Process		1
GO:0060667	branch elongation involved in salivary gland morphogenesis	Biological Process		1
GO:0060661	submandibular salivary gland formation	Biological Process		1
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	Biological Process		2
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	Biological Process	IDA[11923311]	1
GO:0060615	mammary gland bud formation	Biological Process		1
GO:0060496	mesenchymal-epithelial cell signaling involved in lung development	Biological Process		1
GO:0060510	Type II pneumocyte differentiation	Biological Process		2
GO:0060436	bronchiole morphogenesis	Biological Process		1
GO:0060447	bud outgrowth involved in lung branching	Biological Process	IDA[9740653]	1
GO:0060428	lung epithelium development	Biological Process	IDA[9740653]	1
GO:0060430	lung saccule development	Biological Process	IMP[17071719]	3
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	Biological Process	NAS[19152659]	2
GO:0060174	limb bud formation	Biological Process		1
GO:0005615	extracellular space	Cellular Component	IDA[16597614]	126
GO:0005576	extracellular region	Cellular Component		240
GO:0005111	type 2 fibroblast growth factor receptor binding	Molecular Function	IPI[19224135]	1
GO:0005104	fibroblast growth factor receptor binding	Molecular Function	IDA[11923311]	4
GO:0007431	salivary gland development	Biological Process	IMP[17213838]	1
GO:0007368	determination of left/right symmetry	Biological Process		7
GO:0005886	plasma membrane	Cellular Component	IDA[16597614]	772
GO:0005634	nucleus	Cellular Component	IDA[16597614]	770
GO:0001656	metanephros development	Biological Process	IEP[18437684]	7
GO:0001525	angiogenesis	Biological Process		35
GO:0000187	activation of MAPK activity	Biological Process	IDA[14975937]	21
GO:0003338	metanephros morphogenesis	Biological Process		1
GO:0001974	blood vessel remodeling	Biological Process		7
GO:0001823	mesonephros development	Biological Process	IEP[18437684]	2
GO:0001759	organ induction	Biological Process		4
GO:0010838	positive regulation of keratinocyte proliferation	Biological Process	IDA[17449030]	1
GO:0021983	pituitary gland development	Biological Process		4
GO:0010631	epithelial cell migration	Biological Process		1
GO:0010634	positive regulation of epithelial cell migration	Biological Process	IDA[17500053]	3
GO:0030916	otic vesicle formation	Biological Process		3
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	Biological Process		6
GO:0030538	embryonic genitalia morphogenesis	Biological Process		2
GO:0030878	thyroid gland development	Biological Process		7
GO:0008285	negative regulation of cell proliferation	Biological Process		59
GO:0008286	insulin receptor signaling pathway	Biological Process		32
GO:0008083	growth factor activity	Molecular Function	IDA[15690149]	25
GO:0008201	heparin binding	Molecular Function	IDA[11923311]	26
GO:0009880	embryonic pattern specification	Biological Process		5
GO:0009986	cell surface	Cellular Component	IDA[16597614]; NAS[11923311]	70
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process		26
GO:0008589	regulation of smoothened signaling pathway	Biological Process		3
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process	IDA[14975937]	22
GO:0070384	Harderian gland development	Biological Process		1
GO:0070352	positive regulation of white fat cell proliferation	Biological Process		1
GO:0070371	ERK1 and ERK2 cascade	Biological Process	IDA[17959718]	7
GO:0061115	lung proximal/distal axis specification	Biological Process		1
GO:0070075	tear secretion	Biological Process	IMP[19102732]	1
GO:0060915	mesenchymal cell differentiation involved in lung development	Biological Process		1
GO:0061033	secretion by lung epithelial cell involved in lung growth	Biological Process	IDA[10541313]	1
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	Biological Process		9
GO:0071157	negative regulation of cell cycle arrest	Biological Process	IDA[17188682]	3
GO:0071338	positive regulation of hair follicle cell proliferation	Biological Process	IDA[16086254]	1

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05218	Melanoma	12	Melanoma is a form of skin cancer that has a poor prognosis ...... Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes. The only known environmental risk factor is exposure to ultraviolet (UV) light and in people with fair skin the risk is greatly increased. Melanoma pathogenesis is also driven by genetic factors. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Melanoma development has been shown to be strongly associated with inactivation of the p16INK4a/cyclin dependent kinases 4 and 6/retinoblastoma protein (p16INK4a/CDK4,6/pRb) and p14ARF/human double minute 2/p53 (p14ARF/HMD2/p53) tumor suppressor pathways. MITF and TP53 are implicated in further melanoma progression. More...
hsa04810	Regulation of actin cytoskeleton	48
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with FGF10 (count: 51)

Gene Symbol	Pathway Count	Pathway List
VEGFA	15	chemoattractant activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; induction of positive chemotaxis; positive chemotaxis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of epithelial cell proliferation; branching morphogenesis of a tube; extracellular space; extracellular region; angiogenesis; positive regulation of vascular endothelial growth factor receptor signaling pathway; growth factor activity; heparin binding; cell surface;
IL6	14	response to lipopolysaccharide; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA replication; negative regulation of apoptotic process; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of epithelial cell proliferation; epithelial cell proliferation involved in salivary gland morphogenesis; extracellular space; extracellular region; negative regulation of cell proliferation; growth factor activity; positive regulation of ERK1 and ERK2 cascade;
VEGFB	12	chemoattractant activity; negative regulation of apoptotic process; induction of positive chemotaxis; positive chemotaxis; positive regulation of peptidyl-tyrosine phosphorylation; extracellular space; extracellular region; angiogenesis; positive regulation of vascular endothelial growth factor receptor signaling pathway; growth factor activity; heparin binding; positive regulation of ERK1 and ERK2 cascade;
TBX1	12	thymus development; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; odontogenesis of dentin-containing tooth; muscle cell fate commitment; positive regulation of MAPK cascade; positive regulation of epithelial cell proliferation; determination of left/right symmetry; nucleus; angiogenesis; blood vessel remodeling; thyroid gland development;
FGF9	12	positive regulation of MAPK cascade; positive regulation of epithelial cell proliferation; extracellular space; extracellular region; fibroblast growth factor receptor binding; angiogenesis; positive regulation of vascular endothelial growth factor receptor signaling pathway; insulin receptor signaling pathway; growth factor activity; heparin binding; fibroblast growth factor receptor signaling pathway; positive regulation of canonical Wnt receptor signaling pathway;
FGF4	11	positive regulation of transcription from RNA polymerase II promoter; odontogenesis of dentin-containing tooth; negative regulation of apoptotic process; extracellular region; fibroblast growth factor receptor binding; nucleus; insulin receptor signaling pathway; growth factor activity; heparin binding; fibroblast growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade;
MIF	10	chemoattractant activity; positive regulation of fibroblast proliferation; negative regulation of apoptotic process; positive chemotaxis; positive regulation of peptidyl-tyrosine phosphorylation; extracellular space; extracellular region; cell surface; positive regulation of ERK1 and ERK2 cascade; negative regulation of cell cycle arrest;
NTF3	9	chemoattractant activity; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; induction of positive chemotaxis; positive chemotaxis; positive regulation of peptidyl-tyrosine phosphorylation; extracellular region; activation of MAPK activity; growth factor activity;
EREG	9	wound healing; positive regulation of fibroblast proliferation; keratinocyte proliferation; positive regulation of DNA replication; extracellular space; extracellular region; angiogenesis; negative regulation of cell proliferation; growth factor activity;
CTGF	9	response to estradiol stimulus; extracellular space; extracellular region; plasma membrane; angiogenesis; growth factor activity; heparin binding; fibroblast growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade;
INS	8	wound healing; positive regulation of DNA replication; negative regulation of apoptotic process; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; extracellular space; extracellular region; insulin receptor signaling pathway;
GHR	8	response to estradiol stimulus; positive regulation of peptidyl-tyrosine phosphorylation; extracellular space; extracellular region; plasma membrane; nucleus; activation of MAPK activity; cell surface;
IHH	8	pancreas development; extracellular matrix; positive regulation of transcription from RNA polymerase II promoter; embryonic digestive tract morphogenesis; extracellular space; extracellular region; plasma membrane; embryonic pattern specification;
CTSG	7	response to lipopolysaccharide; extracellular matrix; extracellular space; extracellular region; plasma membrane; heparin binding; cell surface;
FOXF1	7	pancreas development; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; embryonic digestive tract morphogenesis; determination of left/right symmetry; nucleus;
FGF3	7	thymus development; extracellular region; organ induction; otic vesicle formation; insulin receptor signaling pathway; growth factor activity; fibroblast growth factor receptor signaling pathway;
FOXC2	7	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; nucleus; metanephros development; blood vessel remodeling; insulin receptor signaling pathway;
HNF1B	7	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; epithelial cell proliferation; branching morphogenesis of a tube; embryonic digestive tract morphogenesis; nucleus;
WNT6	7	positive regulation of transcription, DNA-dependent; odontogenesis of dentin-containing tooth; branching morphogenesis of a tube; extracellular space; extracellular region; plasma membrane; cell surface;
APC	6	somatic stem cell maintenance; thymus development; negative regulation of apoptotic process; plasma membrane; nucleus; negative regulation of cell proliferation;
TGFBR1	6	wound healing; thymus development; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; plasma membrane; angiogenesis;
ETS1	6	response to estradiol stimulus; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; pituitary gland development; negative regulation of cell proliferation;
LPL	6	extracellular matrix; extracellular space; extracellular region; plasma membrane; heparin binding; cell surface;
FOXE1	6	hair follicle morphogenesis; thymus development; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; thyroid gland development;
PLA2G1B	6	positive regulation of fibroblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA replication; extracellular space; extracellular region; activation of MAPK activity;
MAPK1	6	positive regulation of transcription, DNA-dependent; nucleus; activation of MAPK activity; insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway; ERK1 and ERK2 cascade;
MED1	6	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; nucleus; angiogenesis; ERK1 and ERK2 cascade;
TFAP2A	6	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; nucleus; negative regulation of cell proliferation; embryonic pattern specification;
GATA6	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; smooth muscle cell differentiation; Type II pneumocyte differentiation; lung saccule development; nucleus;
GDNF	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; extracellular region; metanephros development; organ induction; growth factor activity;
MAPK3	6	positive regulation of transcription from RNA polymerase II promoter; nucleus; activation of MAPK activity; insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade;
FLT4	6	negative regulation of apoptotic process; positive regulation of MAPK cascade; extracellular region; plasma membrane; nucleus; positive regulation of ERK1 and ERK2 cascade;
IGF2	6	positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; extracellular space; extracellular region; insulin receptor signaling pathway; growth factor activity;
FGF19	6	extracellular region; fibroblast growth factor receptor binding; insulin receptor signaling pathway; growth factor activity; fibroblast growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade;
HES1	5	somatic stem cell maintenance; thymus development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Notch signaling pathway; nucleus;
YAP1	5	somatic stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; nucleus; positive regulation of canonical Wnt receptor signaling pathway;
WNT11	5	protein localization to cell surface; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; extracellular space; plasma membrane;
ADAM17	5	positive regulation of cyclin-dependent protein kinase activity involved in G1/S; response to lipopolysaccharide; spleen development; plasma membrane; cell surface;
SNCA	5	response to lipopolysaccharide; negative regulation of apoptotic process; extracellular region; plasma membrane; nucleus;
TLR4	5	response to lipopolysaccharide; positive regulation of transcription from RNA polymerase II promoter; plasma membrane; activation of MAPK activity; positive regulation of ERK1 and ERK2 cascade;
CRYAB	5	response to estradiol stimulus; negative regulation of apoptotic process; plasma membrane; nucleus; cell surface;
FN1	5	extracellular matrix; extracellular space; extracellular region; angiogenesis; heparin binding;
HOXA3	5	thymus development; nucleus; angiogenesis; blood vessel remodeling; thyroid gland development;
ZBTB16	5	positive regulation of transcription, DNA-dependent; nucleus; mesonephros development; negative regulation of cell proliferation; embryonic pattern specification;
CDH13	5	positive regulation of transcription from RNA polymerase II promoter; keratinocyte proliferation; extracellular space; plasma membrane; negative regulation of cell proliferation;
GSK3B	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; plasma membrane; nucleus; fibroblast growth factor receptor signaling pathway;
PIK3R1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; plasma membrane; insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
BTC	5	negative regulation of apoptotic process; extracellular space; extracellular region; plasma membrane; growth factor activity;
CXCL12	5	negative regulation of apoptotic process; induction of positive chemotaxis; extracellular space; extracellular region; growth factor activity;
ADRA1A	5	positive regulation of MAPK cascade; plasma membrane; nucleus; negative regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade;
ACHE	5	extracellular space; extracellular region; plasma membrane; nucleus; cell surface;

Genes shared at least 2 KEGG pathways with FGF10 (count: 20)

Gene Symbol	Pathway Count	Pathway List
FGF19	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF3	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF4	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF9	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
MAPK1	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
MAPK3	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
PIK3CG	3	Melanoma; Regulation of actin cytoskeleton; Pathways in cancer;
PIK3R1	3	Melanoma; Regulation of actin cytoskeleton; Pathways in cancer;
CRKL	3	Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
BAD	2	Melanoma; Pathways in cancer;
CCND1	2	Melanoma; Pathways in cancer;
PDGFD	2	Melanoma; Regulation of actin cytoskeleton;
APC	2	Regulation of actin cytoskeleton; Pathways in cancer;
FN1	2	Regulation of actin cytoskeleton; Pathways in cancer;
ITGA2	2	Regulation of actin cytoskeleton; Pathways in cancer;
PAK1	2	Regulation of actin cytoskeleton; MAPK signaling pathway;
MAPK9	2	MAPK signaling pathway; Pathways in cancer;
PRKCB	2	MAPK signaling pathway; Pathways in cancer;
RELA	2	MAPK signaling pathway; Pathways in cancer;
TGFBR1	2	MAPK signaling pathway; Pathways in cancer;

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Region: chr5:44303646..44389808 View in gBrowse