ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADRA1A
Previous Symbol	ADRA1C
Symbol Alias	ADRA1L1
Approved Name	adrenergic, alpha-1A-, receptor
Location	8p21.2
Position	chr8:26605667-26724790, -
External Links	HGNC: 277 Entrez Gene: 148 Ensembl: ENSG00000120907 UCSC: uc003xfh.1
No. of Studies	3 (significant: 2; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 3)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Barr CL, 2001(c)	no evidence was found for biased transmission of either allele of the ADRA1C polymorphism to the probands in this sample of ADHD families	Non-significant
Brookes K, 2006	UNPHASED TDT P-value=0.0169, global P-value=0.443, WHAP TDT P_sum P-value=0.162; OR=1.24, one or more SNPs with nominal P-value<0.05 located in this gene	Significant
Hawi, Z., 2012	Although suggestive evidence of association (nominal p <= 0.05) with the genes SLC6A2, ADRA1A, ADRA1B and ADRA2B was observed, none remained significant after permutation adjustments. These findings provide evidence of a contribution of the noradrenaline system to the genetic aetiology of ADHD.	Significant

Gene related SNPs (count: 94)

Literature-origin SNPs (count: 22)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs528257	Chr8:26721296(Fwd)	NMD_transcript_variant; intron_variant	1(0/1/0)
rs523816	Chr8:26703750(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(0/1/0)
rs10110744	Chr8:26685961(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(1/0/0)
rs1157690	Chr8:26610152(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant	1(0/1/0)
rs1048101	Chr8:26628028(Fwd)	NMD_transcript_variant; intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1(0/1/0)
rs11779546	Chr8:26674936(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(1/0/0)
rs11777551	Chr8:26672727(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(1/0/0)
rs2322333	Chr8:26695255(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)
rs10503800	Chr8:26695617(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0/0)
rs472865	Chr8:26698471(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)
rs4732641	Chr8:26617904(Fwd)	NMD_transcript_variant; intron_variant	1(0/1/0)
rs472151	Chr8:26692367(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1(0/1/0)
rs60593443	Chr8:26636906(Fwd)	NMD_transcript_variant; intron_variant; missense_variant; nc_transcript_variant	1(0/1/0)
rs2046186	Chr8:26711214(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1(0/1/0)
rs3808585	Chr8:26724326(Fwd)	intron_variant; upstream_gene_variant	1(0/1/0)
rs17055923	Chr8:26611846(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant	1(0/1/0)
rs2229126	Chr8:26627672(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; missense_variant; upstream_gene_variant	1(1/0/0)
rs577366	Chr8:26697365(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)
rs13274396	Chr8:26716205(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	1(0/1/0)
rs580739	Chr8:26713707(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	1(0/1/0)
rs573514	Chr8:26721281(Fwd)	NMD_transcript_variant; intron_variant	1(1/0/0)
rs574647	Chr8:26697057(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 72)

rs_ID	Location	Functional Annotation
rs498989	Chr8:26691349(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs488323	Chr8:26693973(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs527340	Chr8:26690556(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs526302	Chr8:26690695(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs498194	Chr8:26703221(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs539144	Chr8:26706905(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs499042	Chr8:26698515(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs2036107	Chr8:26701444(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs556793	Chr8:26699067(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs3102087	Chr8:26699937(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs520180	Chr8:26709922(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs522315	Chr8:26710975(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs495495	Chr8:26698168(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs4732639	Chr8:26605110(Fwd)	downstream_gene_variant
rs538378	Chr8:26716715(Fwd)	NMD_transcript_variant; intron_variant; synonymous_variant; upstream_gene_variant
rs489790	Chr8:26716622(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs563097	Chr8:26717123(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs558455	Chr8:26705581(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs523851	Chr8:26703768(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs512131	Chr8:26710792(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs544215	Chr8:26712028(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs536220	Chr8:26728437(Fwd)	upstream_gene_variant
rs2644627	Chr8:26726641(Fwd)	upstream_gene_variant
rs522996	Chr8:26715231(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs1383914	Chr8:26723049(Fwd)	5_prime_UTR_variant; upstream_gene_variant
rs4732652	Chr8:26648746(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs538898	Chr8:26706818(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs10102186	Chr8:26624651(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs511662	Chr8:26706206(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs17055948	Chr8:26616143(Fwd)	NMD_transcript_variant; intron_variant
rs557754	Chr8:26705562(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs13282250	Chr8:26694392(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs7835853	Chr8:26662246(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs17055939	Chr8:26615112(Fwd)	NMD_transcript_variant; intron_variant
rs2036109	Chr8:26616784(Fwd)	NMD_transcript_variant; intron_variant
rs544104	Chr8:26711990(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs486354	Chr8:26710290(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs3802241	Chr8:26623384(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant
rs4236678	Chr8:26618366(Fwd)	NMD_transcript_variant; intron_variant
rs12544507	Chr8:26676427(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs6998591	Chr8:26650822(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs11781115	Chr8:26681450(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs2055197	Chr8:26669717(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs13282836	Chr8:26678206(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs3739215	Chr8:26613408(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant
rs12545761	Chr8:26677891(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs2055195	Chr8:26641025(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs13257637	Chr8:26673902(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs1470221	Chr8:26601618(Fwd)	downstream_gene_variant
rs937351	Chr8:26630737(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs6557946	Chr8:26634589(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs13277287	Chr8:26628765(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1442341	Chr8:26610427(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant
rs7842829	Chr8:26629336(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs10503801	Chr8:26720449(Fwd)	NMD_transcript_variant; intron_variant
rs11135957	Chr8:26652010(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs4732874	Chr8:26645612(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs7015564	Chr8:26684458(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs4548188	Chr8:26646298(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs1390511	Chr8:26644900(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs1874425	Chr8:26645486(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs4732958	Chr8:26719065(Fwd)	NMD_transcript_variant; intron_variant
rs1908654	Chr8:26643243(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs1079078	Chr8:26698047(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs4732682	Chr8:26720893(Fwd)	NMD_transcript_variant; intron_variant
rs13262575	Chr8:26644367(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs11782159	Chr8:26712981(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs13278849	Chr8:26714874(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs12547624	Chr8:26683805(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs4732970	Chr8:26725568(Fwd)	upstream_gene_variant
rs13256192	Chr8:26685346(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs17334323	Chr8:26688826(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
ADRA1A_Cys492Arg	point mutation		1 (0/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 42)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 42)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030018	Z disc	Cellular Component		17
GO:0016049	cell growth	Biological Process		11
GO:0009725	response to hormone stimulus	Biological Process		11
GO:0008285	negative regulation of cell proliferation	Biological Process	TAS[10860850]	59
GO:0035024	negative regulation of Rho protein signal transduction	Biological Process		4
GO:0032229	negative regulation of synaptic transmission, GABAergic	Biological Process		3
GO:0031965	nuclear membrane	Cellular Component		27
GO:0030315	T-tubule	Cellular Component		12
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process		20
GO:0007202	activation of phospholipase C activity	Biological Process		12
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	Biological Process		12
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[10860850]	72
GO:0007568	aging	Biological Process		29
GO:0007512	adult heart development	Biological Process		3
GO:0007267	cell-cell signaling	Biological Process	TAS[8396931]	38
GO:0007243	intracellular protein kinase cascade	Biological Process	TAS[10671514]	19
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process		22
GO:0090037	positive regulation of protein kinase C signaling cascade	Biological Process		6
GO:0060402	calcium ion transport into cytosol	Biological Process		4
GO:0060452	positive regulation of cardiac muscle contraction	Biological Process		2
GO:0097195	pilomotor reflex	Biological Process		1
GO:0043410	positive regulation of MAPK cascade	Biological Process		17
GO:0045760	positive regulation of action potential	Biological Process		2
GO:0035265	organ growth	Biological Process		2
GO:0042493	response to drug	Biological Process		68
GO:0046982	protein heterodimerization activity	Molecular Function		68
GO:0060073	micturition	Biological Process		1
GO:0045907	positive regulation of vasoconstriction	Biological Process		5
GO:0045987	positive regulation of smooth muscle contraction	Biological Process		3
GO:0004937	alpha1-adrenergic receptor activity	Molecular Function	NAS[9490024]; TAS[7737411]	3
GO:0005634	nucleus	Cellular Component		770
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8396931]	220
GO:0006915	apoptotic process	Biological Process	TAS[10671514]	111
GO:0006939	smooth muscle contraction	Biological Process	TAS[8183249]	10
GO:0006950	response to stress	Biological Process		30
GO:0007165	signal transduction	Biological Process	TAS[8396931]	171
GO:0001985	negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure	Biological Process		1
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	Biological Process		3
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	Biological Process		3
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	Biological Process		2
GO:0003084	positive regulation of systemic arterial blood pressure	Biological Process		2

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04270	Vascular smooth muscle contraction	33	The vascular smooth muscle cell (VSMC) is a highly specializ...... The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. More...
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...
hsa04970	Salivary secretion	22	Saliva has manifold functions in maintaining the integrity o...... Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP. More...

Genes shared at least 5 GO terms with ADRA1A (count: 23)

Gene Symbol	Pathway Count	Pathway List
ADRA1B	15	cell growth; nuclear membrane; G-protein coupled receptor signaling pathway; adult heart development; cell-cell signaling; intracellular protein kinase cascade; positive regulation of MAPK cascade; organ growth; protein heterodimerization activity; alpha1-adrenergic receptor activity; nucleus; plasma membrane; integral to plasma membrane; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of the force of heart contraction by epinephrine-norepinephrine;
EDNRA	11	nuclear membrane; T-tubule; elevation of cytosolic calcium ion concentration; activation of phospholipase C activity; G-protein coupled receptor signaling pathway; aging; positive regulation of ERK1 and ERK2 cascade; plasma membrane; integral to plasma membrane; smooth muscle contraction; signal transduction;
ADRB1	8	aging; protein heterodimerization activity; nucleus; plasma membrane; integral to plasma membrane; apoptotic process; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of systemic arterial blood pressure;
ADORA2A	7	negative regulation of cell proliferation; cell-cell signaling; response to drug; protein heterodimerization activity; plasma membrane; integral to plasma membrane; apoptotic process;
IL6	6	cell growth; negative regulation of cell proliferation; aging; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAPK cascade; response to drug;
DRD2	6	negative regulation of cell proliferation; intracellular protein kinase cascade; positive regulation of ERK1 and ERK2 cascade; response to drug; plasma membrane; integral to plasma membrane;
GJA1	6	negative regulation of cell proliferation; cell-cell signaling; plasma membrane; integral to plasma membrane; apoptotic process; signal transduction;
OPRM1	6	negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; plasma membrane; integral to plasma membrane;
BDKRB2	6	elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; protein heterodimerization activity; plasma membrane; integral to plasma membrane; smooth muscle contraction;
CXCR2	6	elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; apoptotic process; signal transduction;
ADRA1D	6	G-protein coupled receptor signaling pathway; cell-cell signaling; alpha1-adrenergic receptor activity; plasma membrane; integral to plasma membrane; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure;
ADRA2C	6	G-protein coupled receptor signaling pathway; cell-cell signaling; protein heterodimerization activity; positive regulation of vasoconstriction; plasma membrane; integral to plasma membrane;
CHRM3	6	G-protein coupled receptor signaling pathway; positive regulation of smooth muscle contraction; plasma membrane; integral to plasma membrane; smooth muscle contraction; signal transduction;
HTR2A	6	aging; response to drug; positive regulation of vasoconstriction; plasma membrane; integral to plasma membrane; response to stress;
PRKD1	6	intracellular protein kinase cascade; nucleus; plasma membrane; integral to plasma membrane; apoptotic process; signal transduction;
FLT4	6	positive regulation of ERK1 and ERK2 cascade; positive regulation of protein kinase C signaling cascade; positive regulation of MAPK cascade; nucleus; plasma membrane; integral to plasma membrane;
CAV3	5	Z disc; cell growth; T-tubule; elevation of cytosolic calcium ion concentration; plasma membrane;
FGF10	5	negative regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAPK cascade; nucleus; plasma membrane;
HTR1B	5	negative regulation of synaptic transmission, GABAergic; G-protein coupled receptor signaling pathway; response to drug; plasma membrane; integral to plasma membrane;
CCR5	5	elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; cell-cell signaling; plasma membrane; integral to plasma membrane;
LPAR1	5	elevation of cytosolic calcium ion concentration; activation of phospholipase C activity; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane;
ADRA2A	5	G-protein coupled receptor signaling pathway; protein heterodimerization activity; plasma membrane; integral to plasma membrane; signal transduction;
ADRB3	5	aging; positive regulation of MAPK cascade; nucleus; plasma membrane; integral to plasma membrane;

Genes shared at least 2 KEGG pathways with ADRA1A (count: 45)

Gene Symbol	Pathway Count	Pathway List
ADRA1B	4	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
ADRA1D	4	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
ADORA2A	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADRB1	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
ADRB2	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
ADRB3	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
CHRM3	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
EDNRA	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADCY4	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
ITPR1	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
ITPR2	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
PLCB2	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
PLCB3	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
PRKCB	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CACNA1C	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1D	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1F	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1S	2	Vascular smooth muscle contraction; Calcium signaling pathway;
GUCY1A2	2	Vascular smooth muscle contraction; Salivary secretion;
PRKG1	2	Vascular smooth muscle contraction; Salivary secretion;
ATP2B3	2	Calcium signaling pathway; Salivary secretion;
NOS1	2	Calcium signaling pathway; Salivary secretion;
RYR3	2	Calcium signaling pathway; Salivary secretion;

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Region: chr8:26605667..26724790 View in gBrowse