ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol ADRA1A
Previous Symbol ADRA1C
Symbol Alias ADRA1L1
Approved Name adrenergic, alpha-1A-, receptor
Location 8p21.2
Position chr8:26605667-26724790, -
External Links HGNC: 277
Entrez Gene: 148
Ensembl: ENSG00000120907
UCSC: uc003xfh.1
No. of Studies 3 (significant: 2; non-significant: 1; trend: 0)
Source Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 3)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Barr CL, 2001(c) no evidence was found for biased transmission of either allele of the ADRA1C polymorphism to the probands in this sample of ADHD families Non-significant
Brookes K, 2006 UNPHASED TDT P-value=0.0169, global P-value=0.443, WHAP TDT P_sum P-value=0.162; OR=1.24, one or more SNPs with nominal P-value<0.05 located in this gene Significant
Hawi, Z., 2012 Although suggestive evidence of association (nominal p <= 0.05) with the genes SLC6A2, ADRA1A, ADRA1B and ADRA2B was observed, none remained significant after permutation adjustments. These findings provide evidence of a contribution of the noradrenaline system to the genetic aetiology of ADHD. Significant

Gene related SNPs (count: 94)

Literature-origin SNPs (count: 22)

LD-proxies (count: 72)

Gene related CNVs (count: 0)

Gene related other variant (count: 1)

Gene related regions (count: 0)

Gene related GO terms (count: 42)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 42)

Gene related KEGG pathways (count: 4)

Genes shared at least 5 GO terms with ADRA1A (count: 23)

Genes shared at least 2 KEGG pathways with ADRA1A (count: 45)

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Region: chr8:26605667..26724790 View in gBrowse
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