ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Study Report

Basic Info

Reference	Brookes K, 200616894395
Citation	Brookes K., Xu X., Chen W., Zhou K., Neale B., Lowe N., Anney R., Franke B., Gill M., Ebstein R., Buitelaar J., Sham P., Campbell D., Knight J., Andreou P., Altink M., Arnold R., Boer F., Buschgens C., Butler L., Christiansen H., Feldman L., Fleischman K., Fliers E., Howe-Forbes R., Goldfarb A., Heise A., Gabriels I., Korn-Lubetzki I., Johansson L., Marco R., Medad S., Minderaa R., Mulas F., Muller U., Mulligan A., Rabin K., Rommelse N., Sethna V., Sorohan J., Uebel H., Psychogiou L., Weeks A., Barrett R., Craig I., Banaschewski T., Sonuga-Barke E., Eisenberg J., Kuntsi J., Manor I., McGuffin P., Miranda A., Oades R. D., Plomin R., Roeyers H., Rothenberger A., Sergeant J., Steinhausen H. C., Taylor E., Thompson M., Faraone S. V. and Asherson P. (2006) "The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes." Mol Psychiatry, 11(10): 934-53.
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	674 families with 776 affected individuals
Predominant Ethnicity	Caucasian
Population	Belgium, Germany, the Netherlands, Ireland, Israel, Spain, Switzerland, United Kingdom
Gender	93.5% male subjects
Age Group	Children/Adolescents : 5-17 years

Detail Info

Summary	To provide further clarification of reported associations and identify novel associated genes, they examined 1038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, in addition to circadian rhythm genes. Analysis used within family tests of association in a sample of 776 DSM-IV ADHD combined type cases ascertained for the International Multi-centre ADHD Gene project. They found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1. Gene-wide tests, adjusted for the number of SNPs analysed in each gene, identified associations with TPH2, ARRB2, SYP, DAT1, ADRB2, HES1, MAOA and PNMT.
Total Sample	European Caucasian subjects were recruited from 12 specialist centres in eight countries: Belgium, Germany, the Netherlands, Ireland, Israel, Spain, Switzerland and United Kingdom. The final data set consisted of 674 families with 776 affected individuals with DSM-IV combined subtype ADHD of which 598 (88.7%) of families had both parents, 73 (10.83%) had only one parent, and three (0.45%) had no parents.
Sample Collection	European Caucasian
Diagnosis Description	All raw data is centralised and stored on a secure database at the MRC Social Genetic Developmental Psychiatry research centre in London. A standardised algorithm is applied to PACS to derive each of the 18 DSM-IV ADHD items, providing operational definitions for each behavioural symptom. These are combined with items that scored 2 or 3 from the teacher rated Conners' ADHD subscale, to generate the total number of items from the DSM-IV symptom checklist. Situational pervasiveness was defined as some symptoms occurring within two or more different situations from the PACS interview, as well as the presence of one or more symptoms scoring 2 or more from the ADHD subscale of the teacher rated Conners'.
Technique	Blood samples were sent immediately following collection by an International Courier service to Rutgers University Cell and DNA repository, New Jersey (RUCDR). These were either used to generate lymphocyte cell lines from which DNA was extracted, or DNA was extracted directly from a portion of the blood sample and lymphocytes cryopreserved for future recovery. In a few cases where individuals were not able to supply a blood sample, they used a mouth swab sampling technique and extracted the DNA at the SGDP laboratories in London. All the SNP genotype assays were completed on a custom array using the Illumina Golden Gate AssayTM (Illumina Inc., San Diego, USA). In addition, they included the analysis of VNTR polymorphisms from exon three of the DRD4, the 3'-untranlsated region and intron 8 of the DAT1, and promotor region of the serotonin transporter (SERT) genes, which had previously been associated with ADHD. Standard PCR protocols were used for all VNTR markers and amplified products visualised on 2% agarose under UV light, as previously described. More detailed descriptions could be found in the original publication.
Analysis Method	Association tests: the main analyses used transmission disequilibrium tests (TDT) implemented using the UNPHASED www.rfcgr.mrc.ac.United Kingdom/~fdudbrid/software/unphased) and WHAP (www.genome.wi.mit.edu/~shaun/whap) programs. Single marker tests of association: for single marker analysis, they used a nominal approach, and two permutation tests to adjust for various multiple testing issues at the gene-wide level. Multimarker tests of association: for haplotype considerations, they adopted two main approaches. They applied the default block definition in HAPLOVIEW (http://www.broad.mit. edu/mpg/haploview) using the method of Gabriel et al and also calculated 5-SNP haplotype associations using the sliding window method implemented in the WHAP program.
Result Description	They found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1. Gene-wide tests, adjusted for the number of SNPs analysed in each gene, identified associations with TPH2, ARRB2, SYP, DAT1, ADRB2, HES1, MAOA and PNMT.

SNPs reported by this study (count: 105)

SNP	Allele Change	Statistical Values	Author Comments	Result of Statistical Analysis
rs1900633	A/T	UNPHASED TDT P-value=0.0227; WHAP TDT P-value=0.006	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs1889189	A/G	UNPHASED TDT P-value=0.835; WHAP TDT P-value=0.393	no significant association was observed no significant association was observed	Non-significant
rs1861647	A/G	UNPHASED TDT P-value=0.133; WHAP TDT P-value=0.325	no significant association was observed no significant association was observed	Non-significant
rs1843809	A/C	UNPHASED TDT P-value=0.00482; WHAP TDT P-value=0.012	positive but with opposite allele, significant association w...... positive but with opposite allele, significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs17574671	A/G	UNPHASED TDT P-value=0.091; WHAP TDT P-value=0.048	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs174611	A/G	UNPHASED TDT P-value=0.039; WHAP TDT P-value=0.076	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs1728818	C/G	UNPHASED TDT P-value=0.143; WHAP TDT P-value=0.050	possible association was observed in WHAP analysis possible association was observed in WHAP analysis	Non-significant
rs17110747	A/G	UNPHASED TDT P-value=0.023; WHAP TDT P-value=0.052	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs1487276	A/G	UNPHASED TDT P-value=0.019; WHAP TDT P-value=0.030	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs1487275	A/C	UNPHASED TDT P-value=0.598; WHAP TDT P-value=0.425	no significant association was observed no significant association was observed	Non-significant
rs1466163	A/G	UNPHASED TDT P-value=0.0386; WHAP TDT P-value=0.142	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs140701	A/G	UNPHASED TDT P-value=0.315; WHAP TDT P-value=0.349	no significant association was observed no significant association was observed	Non-significant
rs1386493	A/G	UNPHASED TDT P-value=0.00302; WHAP TDT P-value=0.010	positive but with opposite allele, significant association w...... positive but with opposite allele, significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs1386491	C/G	UNPHASED TDT P-value=0.342; WHAP TDT P-value=0.319	no significant association was observed no significant association was observed	Non-significant
rs13382977	A/G	UNPHASED TDT P-value=0.0171; WHAP TDT P-value=0.080	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs12843268	A/G	UNPHASED TDT P-value=0.0494	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs2652511	A/G	UNPHASED TDT P-value=0.0182; WHAP TDT P-value=0.120	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs27072	A/G	UNPHASED TDT P-value=0.429; WHAP TDT P-value=0.128	possible association was observed with G allele in WHAP anal...... possible association was observed with G allele in WHAP analysis More...	Non-significant
rs2550948	A/G	UNPHASED TDT P-value=0.0121; WHAP TDT P-value=0.096	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs2601126	A/G	UNPHASED TDT P-value=0.122; WHAP TDT P-value=0.048	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs2423487	A/G	UNPHASED TDT P-value=0.154; WHAP TDT P-value=0.048	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs2550946	A/G	UNPHASED TDT P-value=0.00662; WHAP TDT P-value=0.094	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs2360867	A/G	UNPHASED TDT P-value=0.216; WHAP TDT P-value=0.036	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs2361209	A/G	UNPHASED TDT P-value=0.0654; WHAP TDT P-value=0.012	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs2273506	A/G	UNPHASED TDT P-value=0.637; WHAP TDT P-value=0.916	no significant association was observed no significant association was observed	Non-significant
rs2327264	A/G	UNPHASED TDT P-value=0.161; WHAP TDT P-value=0.038	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs2239448	A/G	UNPHASED TDT P-value=0.0258	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs2242447	A/G	UNPHASED TDT P-value=0.703; WHAP TDT P-value=0.912	no significant association was observed no significant association was observed	Non-significant
rs2042449	A/G	UNPHASED TDT P-value=0.267; WHAP TDT P-value=0.048	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs2229126	A/T	UNPHASED TDT P-value=0.15; WHAP TDT P-value=0.042	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs200173	A/G	UNPHASED TDT P-value=0.012; WHAP TDT P-value=0.034	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs2020942	A/G	UNPHASED TDT P-value=0.195; WHAP TDT P-value=0.309	no significant association was observed no significant association was observed	Non-significant
rs1007023	A/C	UNPHASED TDT P-value=0.00398; WHAP TDT P-value=0.012	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs10061709	A/G	UNPHASED TDT P-value=0.0085	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs10195959	A/G	UNPHASED TDT P-value=0.0239; WHAP TDT P-value=0.100	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs10110744	A/G	UNPHASED TDT P-value=0.259; WHAP TDT P-value=0.048	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs1242068	A/G	UNPHASED TDT P-value=0.0369; WHAP TDT P-value=0.084	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs1242070	A/G	UNPHASED TDT P-value=0.0144; WHAP TDT P-value=0.022	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs1242075	A/G	UNPHASED TDT P-value=0.0123; WHAP TDT P-value=0.034	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs1242076	A/G	UNPHASED TDT P-value=0.0394; WHAP TDT P-value=0.056	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs11714060	A/G	UNPHASED TDT P-value=0.0654; WHAP TDT P-value=0.012	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs11777551	A/G	UNPHASED TDT P-value=0.017; WHAP TDT P-value=0.006	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs11779546	A/G	UNPHASED TDT P-value=0.0236; WHAP TDT P-value=0.032	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs1242058	A/C	UNPHASED TDT P-value=0.038; WHAP TDT P-value=0.042	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs1137070	A/G	UNPHASED TDT P-value=0.0195	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs11564750	C/G	UNPHASED TDT P-value=0.0262; WHAP TDT P-value=0.018	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs11568324	A/G	UNPHASED TDT P-value=0.0153	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs11689432	A/G	UNPHASED TDT P-value=0.617; WHAP TDT P-value=0.022	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs1042098	A/G	UNPHASED TDT P-value=0.137; WHAP TDT P-value=0.044	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs1042717	A/G	UNPHASED TDT P-value=0.0127; WHAP TDT P-value=0.176	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs10513219	A/G	UNPHASED TDT P-value=0.0423; WHAP TDT P-value=0.028	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs1112189	A/G	UNPHASED TDT P-value=0.091; WHAP TDT P-value=0.048	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs8179029	A/G	UNPHASED TDT P-value=0.203; WHAP TDT P-value=0.098	no significant association was observed no significant association was observed	Non-significant
rs7963226	A/G	UNPHASED TDT P-value=0.00386; WHAP TDT P-value=0.012	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs7954568	C/G	UNPHASED TDT P-value=0.00386; WHAP TDT P-value=0.006	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs7751022	A/G	UNPHASED TDT P-value=0.0513; WHAP TDT P-value=0.016	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs952037	A/G	UNPHASED TDT P-value=0.067; WHAP TDT P-value=0.036	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs9316233	C/G	UNPHASED TDT P-value=0.112; WHAP TDT P-value=0.042	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs916457	A/G	UNPHASED TDT P-value=0.055; WHAP TDT P-value=0.038	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs880140	A/G	UNPHASED TDT P-value=0.0285; WHAP TDT P-value=0.202	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs7267923	A/G	UNPHASED TDT P-value=0.0496; WHAP TDT P-value=0.114	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs7208257	A/G	UNPHASED TDT P-value=0.0043; WHAP TDT P-value=0.038	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs6806500	A/G	UNPHASED TDT P-value=0.0922; WHAP TDT P-value=0.042	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs6793522	A/G	UNPHASED TDT P-value=0.0133; WHAP TDT P-value=0.008	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs7645681	A/G	UNPHASED TDT P-value=0.0654; WHAP TDT P-value=0.016	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs7632299	A/G	UNPHASED TDT P-value=0.0895; WHAP TDT P-value=0.028	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs7631319	A/C	UNPHASED TDT P-value=0.197; WHAP TDT P-value=0.026	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs7616384	A/C	UNPHASED TDT P-value=0.0995; WHAP TDT P-value=0.024	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs9850088	A/G	UNPHASED TDT P-value=0.0305; WHAP TDT P-value=0.002	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs9870661	A/T	UNPHASED TDT P-value=0.0654; WHAP TDT P-value=0.012	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs9832471	A/C	UNPHASED TDT P-value=0.0102; WHAP TDT P-value=0.004	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs9848371	A/T	UNPHASED TDT P-value=0.172; WHAP TDT P-value=0.038	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs9873087	A/G	UNPHASED TDT P-value=0.0367; WHAP TDT P-value=0.008	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs3785143	A/G	UNPHASED TDT P-value=0.0117; WHAP TDT P-value=0.110	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs3776513	A/C	UNPHASED TDT P-value=0.0473; WHAP TDT P-value=0.020	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs40184	A/G	UNPHASED TDT P-value=0.0045; WHAP TDT P-value=0.004	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs3787283	A/G	UNPHASED TDT P-value=0.468; WHAP TDT P-value=0.082	no significant association was observed no significant association was observed	Non-significant
rs4448731	A/G	UNPHASED TDT P-value=0.607; WHAP TDT P-value=0.535	no significant association was observed no significant association was observed	Non-significant
rs4350392	A/C	UNPHASED TDT P-value=0.132; WHAP TDT P-value=0.044	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs4680	A/G	UNPHASED TDT P-value=0.698; WHAP TDT P-value=0.441	no significant association was observed no significant association was observed	Non-significant
rs4570625	A/C	UNPHASED TDT P-value=0.459; WHAP TDT P-value=0.347	no significant association was observed no significant association was observed	Non-significant
rs3025399	A/C	UNPHASED TDT P-value=0.074; WHAP TDT P-value=0.050	possible association was observed in WHAP analysis possible association was observed in WHAP analysis	Non-significant
rs2934966	A/C	UNPHASED TDT P-value=0.0078; WHAP TDT P-value=0.030	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs3027407	A/G	UNPHASED TDT P-value=0.0253	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs3027400	A/C	UNPHASED TDT P-value=0.0494	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs362987	A/C	UNPHASED TDT P-value=0.906; WHAP TDT P-value=0.926	no significant association was observed no significant association was observed	Non-significant
rs362567	A/G	UNPHASED TDT P-value=0.0439; WHAP TDT P-value=0.012	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs363020	A/T	UNPHASED TDT P-value=0.0346; WHAP TDT P-value=0.016	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs363006	A/G	UNPHASED TDT P-value=0.204; WHAP TDT P-value=0.729	no significant association was observed no significant association was observed	Non-significant
rs6298	A/G	UNPHASED TDT P-value=0.456; WHAP TDT P-value=0.403	no significant association was observed no significant association was observed	Non-significant
rs6311	A/G	UNPHASED TDT P-value=0.183; WHAP TDT P-value=0.321	no significant association was observed no significant association was observed	Non-significant
rs6313	A/G	UNPHASED TDT P-value=0.159; WHAP TDT P-value=0.271	no significant association was observed no significant association was observed	Non-significant
rs6314	A/G	UNPHASED TDT P-value=0.947; WHAP TDT P-value=0.667	no significant association was observed no significant association was observed	Non-significant
rs6318	C/G	UNPHASED TDT P-value=0.285	no significant association was observed no significant association was observed	Non-significant
rs6347	A/G	UNPHASED TDT P-value=0.391; WHAP TDT P-value=0.106	significant association was observed with A allele in WHAP a...... significant association was observed with A allele in WHAP analysis More...	Non-significant
rs6440161	A/G	UNPHASED TDT P-value=0.0302; WHAP TDT P-value=0.092	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs6582081	A/G	UNPHASED TDT P-value=0.00398; WHAP TDT P-value=0.010	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs4686673	A/G	UNPHASED TDT P-value=0.016; WHAP TDT P-value=0.052	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs4760818	A/T	UNPHASED TDT P-value=0.00327; WHAP TDT P-value=0.010	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
rs498793	A/G	UNPHASED TDT P-value=0.45; WHAP TDT P-value=0.116	no significant association was observed no significant association was observed	Non-significant
rs573514	A/G	UNPHASED TDT P-value=0.106; WHAP TDT P-value=0.042	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant
rs5906754	A/G	UNPHASED TDT P-value=0.0453	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
rs6039806	A/C	UNPHASED TDT P-value=0.555; WHAP TDT P-value=0.607	no significant association was observed no significant association was observed	Non-significant
rs6090384	A/G	UNPHASED TDT P-value=0.763; WHAP TDT P-value=0.575	no significant association was observed no significant association was observed	Non-significant
rs6296	C/G	UNPHASED TDT P-value=0.456; WHAP TDT P-value=0.389	no significant association was observed no significant association was observed	Non-significant

Genes reported by this study (count: 51)

Gene	Statistical Values/Author Comments	Result of Statistical Analysis
SYP	UNPHASED TDT P-value=0.045, global P-value=0.038; OR=1.25, o...... UNPHASED TDT P-value=0.045, global P-value=0.038; OR=1.25, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
CSNK1E	UNPHASED TDT P-value=0.122, global P-value=0.87, WHAP TDT P_...... UNPHASED TDT P-value=0.122, global P-value=0.87, WHAP TDT P_sum P-value=0.491, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
ADRA1A	UNPHASED TDT P-value=0.0169, global P-value=0.443, WHAP TDT ...... UNPHASED TDT P-value=0.0169, global P-value=0.443, WHAP TDT P_sum P-value=0.162; OR=1.24, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
ADRA1B	UNPHASED TDT P-value=0.067, global P-value=0.521, WHAP TDT P...... UNPHASED TDT P-value=0.067, global P-value=0.521, WHAP TDT P_sum P-value=0.246, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
STX1A	UNPHASED TDT P-value=0.146, global P-value=0.485, WHAP TDT P...... UNPHASED TDT P-value=0.146, global P-value=0.485, WHAP TDT P_sum P-value=0.192, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
ADRA2A	UNPHASED TDT P-value=0.141, global P-value=0.505, WHAP TDT P...... UNPHASED TDT P-value=0.141, global P-value=0.505, WHAP TDT P_sum P-value=0.88, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
DBH	UNPHASED TDT P-value=0.0739, global P-value=0.8, WHAP TDT P_...... UNPHASED TDT P-value=0.0739, global P-value=0.8, WHAP TDT P_sum P-value=0.687, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
HTR3B	UNPHASED TDT P-value=0.121, global P-value=0.778, WHAP TDT P...... UNPHASED TDT P-value=0.121, global P-value=0.778, WHAP TDT P_sum P-value=0.81, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
ADRA2C	UNPHASED TDT P-value=0.496, global P-value=0.942, WHAP TDT P...... UNPHASED TDT P-value=0.496, global P-value=0.942, WHAP TDT P_sum P-value=0.972, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
SYT1	UNPHASED TDT P-value=0.0674, global P-value=0.681, WHAP TDT ...... UNPHASED TDT P-value=0.0674, global P-value=0.681, WHAP TDT P_sum P-value=0.271, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
ADRB1	UNPHASED TDT P-value=0.249, global P-value=0.613, WHAP TDT P...... UNPHASED TDT P-value=0.249, global P-value=0.613, WHAP TDT P_sum P-value=0.611, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
HTR2C	UNPHASED TDT P-value=0.248, global P-value=0.677, no SNP wit...... UNPHASED TDT P-value=0.248, global P-value=0.677, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
ADRB2	UNPHASED TDT P-value=0.0127, global P-value=0.094, WHAP TDT ...... UNPHASED TDT P-value=0.0127, global P-value=0.094, WHAP TDT P_sum P-value=0.601; OR=1.3, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
ADRBK1	UNPHASED TDT P-value=0.0879, global P-value=0.485, WHAP TDT ...... UNPHASED TDT P-value=0.0879, global P-value=0.485, WHAP TDT P_sum P-value=0.629, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
ADRBK2	UNPHASED TDT P-value=0.145, global P-value=0.747, WHAP TDT P...... UNPHASED TDT P-value=0.145, global P-value=0.747, WHAP TDT P_sum P-value=0.573, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
DDC	UNPHASED TDT P-value=0.0386, global P-value=0.537, WHAP TDT ...... UNPHASED TDT P-value=0.0386, global P-value=0.537, WHAP TDT P_sum P-value=0.78; OR=1.28, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
ADRB3	UNPHASED TDT P-value=0.218, global P-value=0.838, WHAP TDT P...... UNPHASED TDT P-value=0.218, global P-value=0.838, WHAP TDT P_sum P-value=0.697, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
FADS1	UNPHASED TDT P-value=0.108, global P-value=0.309, WHAP TDT P...... UNPHASED TDT P-value=0.108, global P-value=0.309, WHAP TDT P_sum P-value=0.684, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
FADS2	UNPHASED TDT P-value=0.039, global P-value=0.389, WHAP TDT P...... UNPHASED TDT P-value=0.039, global P-value=0.389, WHAP TDT P_sum P-value=0.798; OR=1.2, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
SLC9A9	UNPHASED TDT P-value=0.01, global P-value=0.485, WHAP TDT P_...... UNPHASED TDT P-value=0.01, global P-value=0.485, WHAP TDT P_sum P-value=0.049; OR=1.61, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
ARRB2	UNPHASED TDT P-value=0.00427, global P-value=0.0166, WHAP TD...... UNPHASED TDT P-value=0.00427, global P-value=0.0166, WHAP TDT P_sum P-value=0.317; OR=1.56, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
ARRB1	UNPHASED TDT P-value=0.206, global P-value=0.854, WHAP TDT P...... UNPHASED TDT P-value=0.206, global P-value=0.854, WHAP TDT P_sum P-value=0.996, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
MAOA	UNPHASED TDT P-value=0.0195, global P-value=0.066; OR=1.31, ...... UNPHASED TDT P-value=0.0195, global P-value=0.066; OR=1.31, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
DRD1	UNPHASED TDT P-value=0.00847, global P-value=0.0454, WHAP TD...... UNPHASED TDT P-value=0.00847, global P-value=0.0454, WHAP TDT P_sum P-value=0.231, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
SLC18A2	UNPHASED TDT P-value=0.084, global P-value=0.83, WHAP TDT P_...... UNPHASED TDT P-value=0.084, global P-value=0.83, WHAP TDT P_sum P-value=0.212, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
BDNF	UNPHASED TDT P-value=0.165, global P-value=0.888, WHAP TDT P...... UNPHASED TDT P-value=0.165, global P-value=0.888, WHAP TDT P_sum P-value=0.534, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
SNAP25	UNPHASED TDT P-value=0.0346, global P-value=0.529, WHAP TDT ...... UNPHASED TDT P-value=0.0346, global P-value=0.529, WHAP TDT P_sum P-value=0.239; OR=1.29, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
ELK3	UNPHASED TDT P-value=0.0117, global P-value=0.349, WHAP TDT ...... UNPHASED TDT P-value=0.0117, global P-value=0.349, WHAP TDT P_sum P-value=0.978; OR=1.4, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
SLC6A1	UNPHASED TDT P-value=0.0934, global P-value=0.916, WHAP TDT ...... UNPHASED TDT P-value=0.0934, global P-value=0.916, WHAP TDT P_sum P-value=0.477, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
DRD3	UNPHASED TDT P-value=0.0959, global P-value=0.828, WHAP TDT ...... UNPHASED TDT P-value=0.0959, global P-value=0.828, WHAP TDT P_sum P-value=0.653, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
NFIL3	UNPHASED TDT P-value=0.0959, global P-value=0.685, WHAP TDT ...... UNPHASED TDT P-value=0.0959, global P-value=0.685, WHAP TDT P_sum P-value=0.723, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
CALY	UNPHASED TDT P-value=0.246, global P-value=0.669, WHAP TDT P...... UNPHASED TDT P-value=0.246, global P-value=0.669, WHAP TDT P_sum P-value=0.948, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
HES6	UNPHASED TDT P-value=0.0949, global P-value=0.228, WHAP TDT ...... UNPHASED TDT P-value=0.0949, global P-value=0.228, WHAP TDT P_sum P-value=0.167, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
HES1	UNPHASED TDT P-value=0.0163, global P-value=0.081, WHAP TDT ...... UNPHASED TDT P-value=0.0163, global P-value=0.081, WHAP TDT P_sum P-value=0.0978; OR=1.23, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
DRD2	UNPHASED TDT P-value=0.0843, global P-value=0.679, WHAP TDT ...... UNPHASED TDT P-value=0.0843, global P-value=0.679, WHAP TDT P_sum P-value=0.567, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
MAOB	UNPHASED TDT P-value=0.239, global P-value=0.737, no SNP wit...... UNPHASED TDT P-value=0.239, global P-value=0.737, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
SLC6A4	UNPHASED TDT P-value=0.194, global P-value=0.832, WHAP TDT P...... UNPHASED TDT P-value=0.194, global P-value=0.832, WHAP TDT P_sum P-value=0.295, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
CHRNA4	UNPHASED TDT P-value=0.0496, global P-value=0.503, WHAP TDT ...... UNPHASED TDT P-value=0.0496, global P-value=0.503, WHAP TDT P_sum P-value=0.593; OR=1.32, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
HTR1E	UNPHASED TDT P-value=0.0513, global P-value=0.509, WHAP TDT ...... UNPHASED TDT P-value=0.0513, global P-value=0.509, WHAP TDT P_sum P-value=0.108; OR=1.42, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
PNMT	UNPHASED TDT P-value=0.0078, global P-value=0.0134, WHAP TDT...... UNPHASED TDT P-value=0.0078, global P-value=0.0134, WHAP TDT P_sum P-value=0.0039; OR=1.67, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
PER1	UNPHASED TDT P-value=0.239, global P-value=0.908, WHAP TDT P...... UNPHASED TDT P-value=0.239, global P-value=0.908, WHAP TDT P_sum P-value=0.595, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
PER2	UNPHASED TDT P-value=0.0171, global P-value=0.124, WHAP TDT ...... UNPHASED TDT P-value=0.0171, global P-value=0.124, WHAP TDT P_sum P-value=0.551; OR=2.07, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
TPH2	UNPHASED TDT P-value=0.003, global P-value=0.0512, WHAP TDT ...... UNPHASED TDT P-value=0.003, global P-value=0.0512, WHAP TDT P_sum P-value=0.136; OR=1.37, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
HTR2A	UNPHASED TDT P-value=0.112, global P-value=0.906, WHAP TDT P...... UNPHASED TDT P-value=0.112, global P-value=0.906, WHAP TDT P_sum P-value=0.641, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
SLC6A3	UNPHASED TDT P-value=0.0045, global P-value=0.109, WHAP TDT ...... UNPHASED TDT P-value=0.0045, global P-value=0.109, WHAP TDT P_sum P-value=0.042; OR=1.26, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
TPH1	UNPHASED TDT P-value=0.299, global P-value=0.884, WHAP TDT P...... UNPHASED TDT P-value=0.299, global P-value=0.884, WHAP TDT P_sum P-value=0.253, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
COMT	UNPHASED TDT P-value=0.137, global P-value=0.9, WHAP TDT P_s...... UNPHASED TDT P-value=0.137, global P-value=0.9, WHAP TDT P_sum P-value=0.752, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
VAMP2	UNPHASED TDT P-value=0.568, global P-value=0.924, WHAP TDT P...... UNPHASED TDT P-value=0.568, global P-value=0.924, WHAP TDT P_sum P-value=0.782, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
DRD4	UNPHASED TDT P-value=0.055, global P-value=0.182, WHAP TDT P...... UNPHASED TDT P-value=0.055, global P-value=0.182, WHAP TDT P_sum P-value=0.132; OR=1.7, one or more SNPs with nominal P-value<0.05 located in this gene More...	Significant
NR4A2	UNPHASED TDT P-value=0.0959, global P-value=0.665, WHAP TDT ...... UNPHASED TDT P-value=0.0959, global P-value=0.665, WHAP TDT P_sum P-value=0.591, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant
HTR1B	UNPHASED TDT P-value=0.198, global P-value=0.928, WHAP TDT P...... UNPHASED TDT P-value=0.198, global P-value=0.928, WHAP TDT P_sum P-value=0.441, no SNP with nominal P-value<0.05 located in this gene More...	Non-significant