ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LPAR1
Previous Symbol	EDG2
Symbol Alias	edg-2, rec.1.3, vzg-1, Gpcr26, Mrec1.3, LPA1, GPR26
Approved Name	lysophosphatidic acid receptor 1
Previous Name	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
Location	9q
Position	chr9:113635543-113800738, -
External Links	HGNC: 3166 Entrez Gene: 1902 Ensembl: ENSG00000198121 UCSC: uc004bfc.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	TAS[9804623]	20
GO:0007202	activation of phospholipase C activity	Biological Process	TAS[9804623]	12
GO:0010977	negative regulation of neuron projection development	Biological Process		4
GO:0009986	cell surface	Cellular Component	IDA[19306925]	70
GO:0005886	plasma membrane	Cellular Component		772
GO:0005543	phospholipid binding	Molecular Function		61
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[8922387]	72
GO:0005887	integral to plasma membrane	Cellular Component	TAS[9070858]	220
GO:0001965	G-protein alpha-subunit binding	Molecular Function		3
GO:0000187	activation of MAPK activity	Biological Process		21
GO:0005515	protein binding	Molecular Function	IPI[19306925]	910
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS[8922387]	236
GO:0071453	cellular response to oxygen levels	Biological Process		1
GO:0071673	positive regulation of smooth muscle cell chemotaxis	Biological Process		1
GO:0043198	dendritic shaft	Cellular Component		11
GO:0051482	elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	Biological Process		5
GO:0060999	positive regulation of dendritic spine development	Biological Process		2
GO:0070915	lysophosphatidic acid receptor activity	Molecular Function		1
GO:0042552	myelination	Biological Process		7
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IEP[12761501]	27
GO:0043197	dendritic spine	Cellular Component		12
GO:0030139	endocytic vesicle	Cellular Component	IDA[19306925]	12
GO:0030165	PDZ domain binding	Molecular Function		13
GO:0032060	bleb assembly	Biological Process		1
GO:0035025	positive regulation of Rho protein signal transduction	Biological Process		2

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04540	Gap junction	27	Gap junctions contain intercellular channels that allow dire...... Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation. More...

Genes shared at least 5 GO terms with LPAR1 (count: 23)

Gene Symbol	Pathway Count	Pathway List
CCR5	6	elevation of cytosolic calcium ion concentration; cell surface; plasma membrane; G-protein coupled receptor signaling pathway; integral to plasma membrane; protein binding;
EDNRA	6	elevation of cytosolic calcium ion concentration; activation of phospholipase C activity; plasma membrane; G-protein coupled receptor signaling pathway; integral to plasma membrane; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;
OPRM1	6	elevation of cytosolic calcium ion concentration; plasma membrane; integral to plasma membrane; G-protein alpha-subunit binding; protein binding; G-protein coupled receptor activity;
FZD4	6	cell surface; plasma membrane; integral to plasma membrane; protein binding; G-protein coupled receptor activity; PDZ domain binding;
ABCA1	6	plasma membrane; phospholipid binding; G-protein coupled receptor signaling pathway; integral to plasma membrane; protein binding; endocytic vesicle;
ADRA1A	5	elevation of cytosolic calcium ion concentration; activation of phospholipase C activity; plasma membrane; G-protein coupled receptor signaling pathway; integral to plasma membrane;
BDKRB2	5	elevation of cytosolic calcium ion concentration; plasma membrane; G-protein coupled receptor signaling pathway; integral to plasma membrane; protein binding;
C3AR1	5	elevation of cytosolic calcium ion concentration; plasma membrane; G-protein coupled receptor signaling pathway; integral to plasma membrane; G-protein coupled receptor activity;
S1PR3	5	elevation of cytosolic calcium ion concentration; plasma membrane; G-protein coupled receptor signaling pathway; integral to plasma membrane; G-protein coupled receptor activity;
ADAM17	5	cell surface; plasma membrane; integral to plasma membrane; protein binding; PDZ domain binding;
GHR	5	cell surface; plasma membrane; integral to plasma membrane; activation of MAPK activity; protein binding;
GRIN2A	5	cell surface; plasma membrane; integral to plasma membrane; protein binding; positive regulation of apoptotic process;
NRXN1	5	cell surface; plasma membrane; integral to plasma membrane; protein binding; endocytic vesicle;
APOA1	5	plasma membrane; phospholipid binding; G-protein coupled receptor signaling pathway; protein binding; endocytic vesicle;
CASR	5	plasma membrane; G-protein coupled receptor signaling pathway; integral to plasma membrane; protein binding; G-protein coupled receptor activity;
DRD2	5	plasma membrane; integral to plasma membrane; protein binding; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; endocytic vesicle;
DRD3	5	plasma membrane; G-protein coupled receptor signaling pathway; integral to plasma membrane; protein binding; endocytic vesicle;
DRD4	5	plasma membrane; integral to plasma membrane; activation of MAPK activity; protein binding; dendritic spine;
GJA1	5	plasma membrane; integral to plasma membrane; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; PDZ domain binding;
GRM1	5	plasma membrane; G-protein coupled receptor signaling pathway; integral to plasma membrane; activation of MAPK activity; G-protein coupled receptor activity;
PRKD1	5	plasma membrane; phospholipid binding; integral to plasma membrane; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
RXFP3	5	plasma membrane; G-protein coupled receptor signaling pathway; integral to plasma membrane; G-protein coupled receptor activity; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;
TLR4	5	plasma membrane; integral to plasma membrane; activation of MAPK activity; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;

Genes shared at least 2 KEGG pathways with LPAR1 (count: 7)

Gene Symbol	Pathway Count	Pathway List
ADRB1	2	Neuroactive ligand-receptor interaction; Gap junction;
DRD1	2	Neuroactive ligand-receptor interaction; Gap junction;
DRD2	2	Neuroactive ligand-receptor interaction; Gap junction;
GRM1	2	Neuroactive ligand-receptor interaction; Gap junction;
GRM5	2	Neuroactive ligand-receptor interaction; Gap junction;
HTR2A	2	Neuroactive ligand-receptor interaction; Gap junction;
HTR2C	2	Neuroactive ligand-receptor interaction; Gap junction;

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Region: chr9:113635543..113800738 View in gBrowse