ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol HTR2A
Previous Symbol HTR2
Symbol Alias 5-HT2A
Approved Name 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Previous Name "5-hydroxytryptamine (serotonin) receptor 2A"
Location 13q14-q21
Position chr13:47405685-47471169, -1
External Links HGNC: 5293
Entrez Gene: 3356
Ensembl: ENSG00000102468
UCSC: uc010acr.4
No. of Studies 13 (significant: 7; non-significant: 6; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 13)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Ribases M, 2009(b) Haplotype analysis: P-value=0.0036, OR=1.63 for adults combined ADHD; P-value=0.0084, OR=1.49 for childhood combined ADHD. showed evidence of association only with the combined ADHD subtype both in adults and children. Significant
Pazvantoglu, O.,2013 5-HT2A is significant associated with ADHD in this study. Significant
Quist JF, 2000 haplotype TDT: global P=0.38, smallest P=0.09 for haplotype 102T/452Tyr. No evidence was found for preferential transmission of any HTR2A haplotype to the affected child. Evidence for linkage disequilibrium between the 452Tyr allele of the HTR2A His452Tyr polymorphism and ADHD was found. Significant
Gizer IR, 2009 The present study does not support a relation between ADHD and this gene. Non-significant
Hawi Z, 2002 Analysis of HTR2A failed to reveal evidence of association or linkage between the His452Tyr polymorphism and ADHD in the total sample. However, a significantly increased transmission of the allele 452His was observed in the Irish sample alone. Significant
Brookes K, 2006 UNPHASED TDT P-value=0.112, global P-value=0.906, WHAP TDT P_sum P-value=0.641, no SNP with nominal P-value<0.05 located in this gene Non-significant
Oades RD, 2008 2 SNPs showed significant association Significant
Bobb AJ, 2005 no polymorphism was associated with ADHD Non-significant
Cho, S. C., 2012 The results of this study suggest that there is a significant genetic association between the T102C polymorphism in the serotonin 2A receptor gene and ADHD in Korean children. Significant
Guimaraes AP, 2007 a trend association between a polymorphism in this gene and ADHD was detected. Significant
Zoroglu SS, 2003 two investigated polymorphisms were not siginificantly associated with ADHD Non-significant
Heiser P, 2007 3 SNPs showed no association to ADHD in their sample Non-significant
Li J, 2006(e) no biased transmission of any alleles of the 102T>C and -1438A>G was observed Non-significant

Gene related SNPs (count: 67)

Literature-origin SNPs (count: 14)

LD-proxies (count: 53)

Gene related CNVs (count: 0)

Gene related other variant (count: 3)

Gene related regions (count: 0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

Gene related KEGG pathways (count: 3)

Genes shared at least 5 GO terms with HTR2A (count: 30)

Genes shared at least 2 KEGG pathways with HTR2A (count: 38)

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Region: chr13:47405685..47471169 View in gBrowse
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