ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol ADRA1B
Approved Name adrenergic, alpha-1B-, receptor
Location 5q33.3
Position chr5:159343740-159400017, +
External Links HGNC: 278
Entrez Gene: 147
Ensembl: ENSG00000170214
UCSC: uc003lxt.1
No. of Studies 2 (significant: 1; non-significant: 1; trend: 0)
Source Literature-origin; Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Gene related studies (count: 2)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Brookes K, 2006 UNPHASED TDT P-value=0.067, global P-value=0.521, WHAP TDT P_sum P-value=0.246, no SNP with nominal P-value<0.05 located in this gene Non-significant
Hawi, Z., 2012 Although suggestive evidence of association (nominal p <= 0.05) with the genes SLC6A2, ADRA1A, ADRA1B and ADRA2B was observed, none remained significant after permutation adjustments. A rare ADRA1B haplotype made of six SNPs (rs2030373, rs6884105, rs756275, rs6892282, rs6888306 and rs13162302) was also associated (chi(2) = 7.79, p-corrected = 0.042 OR = 2.74) with the disorder. These findings provide evidence of a contribution of the noradrenaline system to the genetic aetiology of ADHD. Significant

Gene related SNPs (count: 41)

Literature-origin SNPs (count: 11)

LD-proxies (count: 30)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)

Gene related KEGG pathways (count: 4)

Genes shared at least 5 GO terms with ADRA1B (count: 17)

Genes shared at least 2 KEGG pathways with ADRA1B (count: 45)

View in gBrowse

Region: chr5:159343740..159400017 View in gBrowse
View in gBrowse