ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol DRD5
Previous Symbol DRD1L2
Symbol Alias DRD1B
Approved Name dopamine receptor D5
Location 4p16.1
Position chr4:9783258-9785633, +
External Links HGNC: 3026
Entrez Gene: 1816
Ensembl: ENSG00000169676
UCSC: uc003gmb.3
No. of Studies 22 (significant: 14; non-significant: 6; trend: 2)
Source Literature-origin; Mapped by CNV; Mapped by literature SNP

Gene related studies (count: 22)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Feng J, 1998 One previously identified silent polymorphism at base pair 978 (P326P) was identified in the DRD5 gene among ADHD samples. Trend
Kirley A, 2002 Significant preferential transmission of allele at DRD5 (148bp allele) Significant
Payton A, 2001 there was a trend for preferential transmission of the DRD5 148 bp marker allele Non-significant
Barr CL, 2000 (c) Significant evidence for biased transmission of two alleles, the 136-bp allele and the 146-bp allele, were observed. Significant
Tahir E, 2000 (b) no significant evidence was found Non-significant
Lowe N, 2004 (b) The joint analysis showed association with the DRD5 locus and this association appears to be confined to the predominantly inattentive and combined clinical subtypes Significant
Kustanovich V, 2004 an association of a dinucleotide repeat polymorphism near the DRD5 gene with ADHD was replicated. Significant
Hawi Z, 2003 3 markers within this gene showed significant association with ADHD; minimal 2-marker_haplotype 2.6 (DRD5-1481, DRD5-PCR1) P-value=0.00016, X2(1df)=14.2, global X2=22.4, 11 df, P-value=0.021 which showed significant excess transmission to the ADHD cases; minimal 3-marker_haplotype 2.2.6 (DRD5-1481, D5S1582, DRD5-PCR1) P-value=0.0013, X2(1df)=10.458, global X2=41.8, 25 df, P-value=0.0189 which showed preferentially transmitted to the ADHD cases Significant
Maher BS, 2002 for DRD5, positive association was demostrated with ADHD in the meta-analysis and there was no support for hetergeneity between studies Significant
Bobb AJ, 2005 no polymorphism was associated with ADHD Non-significant
Bakker SC, 2005 DRD5 did not contribute substantially to ADHD in the Dutch population Non-significant
Manor I, 2004 The current report confirmed taht the most common 148 bp DRD5 microsatellite repeat allele is preferentially transmitted to the ADHD proband Significant
Mill J, 2004 (a) significant association for an allele of D4S615 was found, but a global test incorporating all alleles of this marker was not significant. Significant
Hawi Z, 2005 one marker showed significant overtransmission of paternal alleles; paternal versus maternal transmissions, combined TDT P-value=0.0019, X2=9.6 (1df), OR=1.56; TDT P-value=0.0024, X2=9.2 when DRD5 was removed in sensitivity analysis Significant
Li D, 2006 DRD5 148-bp showed a significant association, there is a statistically significant association between ADHD and DRD5 Significant
Nyman ES, 2007 No evidence of association was seen. Non-significant
Johansson S, 2008 a nominally significant overall association between ADHD and the DRD5 microsatellite marker Significant
Squassina A, 2008 DRD5 (CA)n repeat has a modest effect in modulating susceptibility to adult ADHD Significant
Langley K, 2009 DRD5 CA(n) microsatellite significantly predicted baseline persistent ADHD diagnosis . Significant
Gizer IR, 2009 The present study provides significant evidence suggesting an association between childhood ADHD and this gene. Significant
Lionel, A. C., 2011 Rare inherited CNVs in ADHD probands which absent in controls overlapped with DRD5 which is previously implicated ADHD loci. Trend
Carpentier, P. J., 2012 No significant association was found. Non-significant

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 1)

Gene related other variant (count: 7)

Gene related regions (count: 0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 27)

Gene related KEGG pathways (count: 2)

Genes shared at least 5 GO terms with DRD5 (count: 9)

Genes shared at least 2 KEGG pathways with DRD5 (count: 30)

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Region: chr4:9783258..9785633 View in gBrowse
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