Maher BS, 200212454525
||Maher B. S., Marazita M. L., Ferrell R. E. and Vanyukov M. M. (2002) "Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis." Psychiatr Genet, 12(4): 207-15.
||Candidate association study
||They applied a random-effects model meta-analysis to family-based studies of association between ADHD and the dopamine system genes DRD4, DRD5 and DAT1. A statistical test of heterogeneity was conducted for each group of studies. The meta-analysis of DRD4 included data from 13 studies, with a total of 571 informative meioses. The pooled odds ratio estimate was 1.41, demonstrating positive association. For DRD5, data from five studies, with a total of 340 informative meioses, were combined yielding a pooled odds ratio of 1.57. Eleven studies examining DAT1, with a total of 824 informative meioses, yielded a non-significant pooled odds ratio estimate of 1.27. There was no support of heterogeneity between the studies. Overall, the meta-analyses support the involvement of the dopamine system genes in ADHD liability variation and suggest the need for studies examining interactions between these genes.
Genes reported by this study: 3