An Overview of ADHDgene

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders which attacks in childhood and may persist into adolescence and adulthood. Empirical data from clinical studies consistently support the polygenetic nature of ADHD with estimated heritability ranging from 75%-91%. To study the genetic basis of ADHD is of fundamental importance in uncovering disease mechanism and in developing effective methods for ADHD diagnosis, treatment and prevention.

In recent years, studies aiming to explore genetic susceptibility of ADHD have been increasing. There is a growing need to integrate the data from multiple genetic studies for convenience of in-depth data mining. So far there has been no such effort for ADHD. ADHDgene is thus developed to fulfill this need. The core data of ADHDgene were collected from numerous original publications with profound literature screening by manual curation. To provide new candidates for novel discovery of ADHD, extended data were obtained from extended functional analysis based on the core data, including linkage disequilibrium (LD) analysis of the literature-origin SNPs, pathway-based analysis (PBA) for the GWAS data of ADHD and gene mapping. ADHDgene covers a broad range of genetic factors, not only SNPs and genes, but also variants like CNV, VNTR, and microsatellite, as well as regions and pathways. Moreover, powerful search tools and a graphical browser were developed to facilitate the navigation of the data and data connections. As the first genetic database of ADHD, ADHDgene aims to provide research community with a central genetic resource and analysis platform for ADHD, to help unveil the genetic basis of ADHD and to contribute to global mental health.

ADHDgene will be updated monthly.

Search by Chromosome

Click to view ADHD related genetic factors on each chromosome
1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	X	Y

Location	e.g. 16p13
Chr: Start-End	: -