| Reference |
Statistical Values/Author Comments |
Result of Statistical Analysis |
| Holmes J, 2000 |
No evidence of association with the SLC6A3 polymorphism was found. |
Non-significant
|
| Barr CL, 2001(a) |
haplotype '3' (VNTR 480-bp allele/intron 9 allele 2/exon 9 allele 2), TDT P-value=0.003, X2=9.135, significant evidence for biased transmission was detected; and there was also evidence that two of the haplotypes, haplotype '2' (VNTR 480bp allele/intron 9 allele 2/exon 9 allele 1) and haplotype '11' (VNTR 440-bp allele/intron 9 allele 2/exon 9 allele 2) were preferentially not transmitted to the ADHD children. In the TRANSMIT program, the transmission of haplotype '3' to the ADHD probands was significant (X2=7.301, P-value=0.007). There was also evidence for biased nontransmission of haplotype '2' (X2=3.624, P-value=0.057) and haplotype '11' (X2=6.042, P-value=0.014) to ADHD children. |
Significant
|
| Gill M, 1997 |
Results in this study confirm the findings of Cook et al of an association between ADHD and the dopamine transporter gene by examining the 3' UTR VNTR polymorphism. |
Significant
|
| Waldman ID, 1998 |
Results in this study replicated and extended previous findings of the association between the DAT1 gene and childhood ADHD by using 3'-UTR VNTR (480-bp) as marker. |
Significant
|
| Chen CK, 2003 |
found evidence of increased transmission of the 10-repeat allele using TRANSMIT and supported the role of SLC6A3 in ADHD susceptibility among Asian populations |
Significant
|
| Smith KM, 2003 |
no polymorphism was significantly associated with ADHD |
Non-significant
|
| Hawi Z, 2003 |
2 markers within this gene showed significant association with ADHD; minimal 2-marker_haplotype 2.3 (VNTR-1981) P-value=0.0004, X2(1df)=12.37, global X2(13df)=21.3, P-value=0.067 which showed increased transmission to ADHD; minimal 3-marker_haplotype 4.2.3 (D5S2005-VNTR-D5S1981) P-value=0.0025, X2(1df)=9.1413, global X2(13df)=19.4, P-value=0.11 which showed a significant preferential transmission to ADHD cases |
Significant
|
| Maher BS, 2002 |
for SLC6A3, no positive association was demostrated with ADHD in the meta-analysis and there was no support for hetergeneity between studies |
Non-significant
|
| Kirley A, 2002 |
current study confirmed the previously reported association of SLC6A3 (480bp allele) with ADHD |
Significant
|
| Todd RD, 2001(a) |
the results of the current study offer no support for association of the SLC6A3 gene with ADHD in a population-based sample of twins |
Non-significant
|
| Roman T, 2001 |
no polymorphism was significantly associated with ADHD, and no main effects of SLC6A3 and ADHD by using dimensional Analyses |
Non-significant
|
| Curran S, 2001 |
TDT analysis of 480bp repeat allele of SLC6A3 was associated with ADHD in the UK sample, but not in the Turkish sample and only a marginal change in overall significance was found in the combined analysis |
Significant
|
| Feng Y, 2005(a) |
one haplotype of five markers, TRANSMIT P-value=0.005, X2=8.051; Global X2=38.449, 24 d.f., P-value=0.031; common haplotypes (those with frequencies>10%) X2=15.209, 3 d.f., P-value=0.002; SLC6A3 was associated with ADHD in this sample |
Significant
|
| Langley K, 2005 |
no SNP showed significant association with ADHD; global transmit P-value=0.85 of 4-marker haplotype, yielded no evidence for association at a global level or for any specific single haplotype |
Non-significant
|
| Simsek M, 2005 |
distribution of two common alleles (9R, 10R) and 5 rare ones (3R, 6R, 7R, 8R, 11R) had no significant differences between cases and controls |
Non-significant
|
| Ouakil DP, 2005 |
the meta-analysis showed no significant association between ADHD and the SLC6A3 gene, but an important between-samples heterogeneity |
Non-significant
|
| Bobb AJ, 2005 |
no polymorphism was associated with ADHD |
Non-significant
|
| Bakker SC, 2005 |
haplotype SLC6A3, TDT P-value=0.21; SLC6A3 did not contribute substantially to ADHD in the Dutch population |
Non-significant
|
| Qian Q, 2004 |
long repeat alleles (11-12 repeats) were associated with the disorder in the case-control analyses but not family-base analyses. |
Significant
|
| Kustanovich V, 2004 |
No evidence for an association was found |
Non-significant
|
| Gizer IR, 2009 |
The present study provides significant evidence suggesting an association between childhood ADHD and this gene. |
Significant
|
| Doyle C, 2009 |
Association signal was identified in the 5' region of this gene. |
Significant
|
| Gabriela ML, 2009 |
genotype analysis P-value=0.57, allelic analysis P-value=0.55, TDT P-value=0.8. No significant differences between groups of comparison. |
Non-significant
|
| Xu X, 2009(b) |
For haplotype -67T/-839T: P-value=0.0004 in Tanwanese sample, P-value=0.004 in combined sample; for haplotype -67A/-839T: P-value=0.0003 in Tanwanese sample, P-value=0.001 in combined sample. 1 SNP in this gene shown association with ADHD in Taiwanese sample. Haplotype analysis shown the association between ADHD and certain haplotypes presented by these two SNPs. |
Significant
|
| Aparecida da Silva M, 2011 |
allelic chi-square test P=0.75 (5df); genotypic chi-square test P=0.61 (9df). There is no association between adult ADHD and VNTR 3'UTR polymorphism. |
Non-significant
|
| Shang CY, 2011 |
haplotype C/T of rs27048 and rs429699, FBAT P-value=0.008 for inattentive subtype, showing that variation in the SLC6A3 gene may primarily affect the inattentive subtype of ADHD |
Significant
|
| Franke B, 2010 |
haplotype 9-6 formed by the 3'-UTR and Intron 8 VNTRs, logistic regression P-value<0.001, X2 =20.36, df=2; haplotype 9-6 meta-analysis, P-value=0.03, OR=1.39; P-value=0.04, OR=1.47 with ADHD hyperactivity subtypes; SLC6A3 has a modulatory rather than causative role in ADHD |
Significant
|
| Silva MA, 2009 |
The present study provides evidence for the association between the 6-repeat allele of SLC6A3 intron 8 VNTR and ADHD in their Brazilian sample of adult patients. |
Significant
|
| Das M, 2011 |
minimum UNPHASED P-value=0.002, X2=9.33 for 10R-6R haplotype frequencies in the case-control analysis, which showed that the 10R-6R haplotype was significantly higher in controls; minimum ETDT P-value=0.09 showed no significant over transmission of any haplotypes |
Significant
|
| Sanchez-Mora C, 2011 |
P-value=3.04e-05, OR=1.66; P-value=2.66e-05, OR=1.74 of DRD4 L-4R and SLC6A3 9R-6R increased the risk for ADHD in both the ADHD sample as a whole and in the combined clinical subtype respectively which suggested additive effects of the DRD4 risk haplotype and the SLC6A3 gene |
Significant
|
| Ilott NE, 2010 |
1 SNP showed modest, nominally significant association in the AT tests at ages 2 and 3 |
Significant
|
| Bidwell LC, 2011 |
The current analysis replicated previously found associations with ADHD and 3' untranslated region of the SLC6A3 gene, with the 10-repeat allele conferring greater risk for ADHD symptoms. |
Significant
|
| El-Tarras, A. E., 2012 |
These findings support the hypothesis that some of the MAOA and DAT1 polymorphisms have a causative role in the development of ADHD in the Saudi population. |
Significant
|
| Spencer, T. J., 2012 |
the gene frequencies of each of the gene polymorphisms assessed did not differ between the ADHD and control groups. |
Non-significant
|
| Brown, A. B., 2011 |
These findings replicate the association of the 9R allele with adult ADHD. |
Significant
|
| Hoogman, M., 2012 |
A higher prevalence of the risk haplotype was found in adults with ADHD compared with healthy controls, [X2= 10.04, P-value=0.002]. |
Significant
|
| Kim YS, 2005 |
did not show preferential transmission of any allele or gene-gene interaction |
Non-significant
|
| Mazei-Robison MS, 2005 |
multiple hSLC6A3 sequence variants were identified, including five novel variants, as well as one nonsynonymous single nucleotide polymorphism (SNP), converting Ala559 to Val (A559V). |
Trend
|
| Todd RD, 2005 |
no significant associations were found for SLC6A3 polymorphisms using DSM-IV ADHD subtypes |
Non-significant
|
| Carrasco X, 2006 |
SLC6A3 10-repeat alleles Fisher¡¯s exact test P-value>0.25, DRD4 7-repeat heterozygosity and SLC6A3 10 allele homozygosity Fisher¡¯s exact test P-value=0.0096; OR=12.71, suggested evidence of gene-gene interaction effects on the prevalence of ADHD in the Chilean population |
Significant
|
| Kim JW, 2006 |
9/10 genotype chi-square P-value=0.02, OR=4.12, X2=13.45 in the ADHD probands, chi-square P-value=0.03, X2=11.60 in parents of probands; a possible association between SLC6A3 9-repeat allele and the impulsivity phenotype |
Significant
|
| Hawi Z, 2005 |
one marker showed significant overtransmission of paternal alleles; paternal versus maternal transmissions, combined TDT P-value=0.0019, X2=9.6 (1df), OR=1.56; TDT P-value=0.013, X2=6.1 when SLC6A3 was removed in sensitivity analysis |
Significant
|
| Brookes KJ, 2006(b) |
haplotype 10/3 of 3' UTR VNTR and intron 8 VNTR, P-value<0.001, OR=2.56, X2 =12.25 in the Taiwanese sample and P-value<0.001, OR=2.59, X2 =15.5 in the English sample, a novel association was identified |
Significant
|
| Cheuk DK, 2006(b) |
Case-Control test: 10/10 repeat genotype P-value=0.46, OR=0.69; 9/10 repeat genotype P-value=0.26, OR=1.93. VNTR polymorphism of the SLC6A3 gene is not associated with ADHD in Chinese children |
Non-significant
|
| Lim MH, 2006 |
10-repeat allele was preferentially transmitted to ADHD children, which supports the role of SLC6A3 in ADHD susceptibility among Asian populations |
Significant
|
| Simsek M, 2006 |
indicated absence of any strong association between SLC6A3-VNTR polymorphism and ADHD cases in Oman |
Non-significant
|
| Li D, 2006 |
SLC6A3 520-bp risk allele (P-value=0.05) showed a weak significant association |
Significant
|
| Ohadi M, 2006 |
the findings provided tentative evidence of the contribution of the SLC6A3 gene core promoter polymorphism to the etiopathophysiology of ADHD at least in the Iranian population |
Significant
|
| Brookes K, 2006 |
UNPHASED TDT P-value=0.0045, global P-value=0.109, WHAP TDT P_sum P-value=0.042; OR=1.26, one or more SNPs with nominal P-value<0.05 located in this gene |
Significant
|
| Qian Q, 2007 |
Logistic Regression Analysis: P-value=0.038, OR=3.066, 95%CI=1.064-8.835. Result show that the effects of the risk alleles of SLC6A3 found in the univariate analyses remained significant after partialing out the effects of the other putative risk alleles. |
Significant
|
| Genro JP, 2007 |
Results in this study suggest a role for the promoter region of SLC6A3 gene in ADHD susceptibility in the Brazilian sample. |
Significant
|
| Asherson P, 2007 |
haplotype-specific P-value=0.002, OR=1.27. VNTR polymorphisms in its 3' UTR and intron 8 were associated with combined ADHD. |
Significant
|
| Das M, 2007 |
SLC6A3 3'-UTR 9R allele was proved to be over-transmitted in ADHD subjects. |
Significant
|
| Bruggemann D, 2007 |
no association was found, neither when testing single markers nor haplotypes |
Non-significant
|
| Friedel S, 2007 |
nominal P-value=0.000034 for family-based association study of haplotypes of SNPs rs6350-rs403636-rs463379. solid association for a single SNP and a haplotype in this gene were shown. |
Significant
|
| Yang B, 2007 |
Evidence of a small but significantly positive association between the SLC6A3 10 repeat allele and ADHD was shown. |
Significant
|
| Nyman ES, 2007 |
Some evidence of association was found for a SNP (rs12516948) in the 3'-UTR of SLC6A3. |
Significant
|
| Banoei MM, 2008 |
no association between the SLC6A3 10-repeat allele and ADHD |
Non-significant
|
| Ouellet-Morin I, 2008 |
a significant association was found for the rs27072 polymorphism and symptoms of inattention and hyperactivity/ impulsivity |
Significant
|
| Johansson S, 2008 |
no association between ADHD and the SLC6A3 polymorphism |
Non-significant
|
| Langley K, 2009 |
SLC6A3 480 bp VNTR is not associated with persistent ADHD or baseline ADHD. |
Non-significant
|
| Wohl M, 2008 |
The TDT for 10-R allele shows a perfect lack of transmission bias |
Non-significant
|
| Wang Y, 2007 |
findings do not support the hypothesis that SLC6A3 gene variants contribute to the pathogenesis of ADHD in Chinese Han population |
Non-significant
|
| Brookes KJ, 2008(a) |
two marker haplotype P-value=0.00002; four marker haplotype GGGC P-value=1.8E-6; the most significant finding occurred between rs2550946 and rs40184; a four-marker haplotype displays significant over transmission to ADHD probands |
Significant
|
| Franke B, 2008 |
Haplo.score global P-value=0.01 showed global evidence for association of SLC6A3 with adult ADHD; score test P-value=0.001 of 9-6 SLC6A3-haplotype which was significantly more frequent in cases than in controls |
Significant
|
| Genro JP, 2008 |
haplotype A/C/C/C/A derived from five SNPs (rs2550948, rs11564750, rs261759, rs2652511, rs2975223) in 5' region, TDT P-value=0.018 after correction |
Significant
|
| Niederhofer H, 2008 |
they did not observe an association of ADHD with SLC6A3 polymorphism neither by the haplotype relative risk (HRR) method nor by the transmission disequilibrium test (TdT) method. |
Non-significant
|
| Oades RD, 2008 |
1 SNP showed significant association |
Significant
|
Hot Results
Basic Info
Gene related CNVs (count: 0)
