ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GRM7
Symbol Alias	GLUR7, GPRC1G, mGlu7, MGLUR7
Approved Name	glutamate receptor, metabotropic 7
Location	3p26-p25
Position	chr3:6811688-7783218, +
External Links	HGNC: 4599 Entrez Gene: 2917 Ensembl: ENSG00000196277 UCSC: uc003bql.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by CNV

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Elia, J., 2012	This gene was found directly affected by CNVRs overrepresented in individuals with ADHD.	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_24	chr3:7183953-7197236 (NCBI Build 35 (hg17))	13284	3p26.1	Deletion (hemizygous)	Paternal
CNV_Elia[2012]_3	chr3:7183953-7197236 (NCBI36 / hg18)	13284	3p26.1	Del	0:2:0(100%)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030534	adult behavior	Biological Process		5
GO:0030818	negative regulation of cAMP biosynthetic process	Biological Process	IDA[9473604]	7
GO:0032279	asymmetric synapse	Cellular Component		4
GO:0042734	presynaptic membrane	Cellular Component		15
GO:0016595	glutamate binding	Molecular Function	IDA[9473604]	3
GO:0030165	PDZ domain binding	Molecular Function	NAS[12052533]	13
GO:0030424	axon	Cellular Component		35
GO:0030425	dendrite	Cellular Component	IDA[9630572]	46
GO:0043198	dendritic shaft	Cellular Component		11
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0048786	presynaptic active zone	Cellular Component		4
GO:0070905	serine binding	Molecular Function	IDA[9144652]	1
GO:0005887	integral to plasma membrane	Cellular Component	NAS[9473604]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0007194	negative regulation of adenylate cyclase activity	Biological Process	IDA[9473604]	10
GO:0005938	cell cortex	Cellular Component	IDA[9630572]	26
GO:0005245	voltage-gated calcium channel activity	Molecular Function		22
GO:0001662	behavioral fear response	Biological Process	IMP[17167337]	7
GO:0005509	calcium ion binding	Molecular Function	IDA[18599484]	124
GO:0005246	calcium channel regulator activity	Molecular Function		10
GO:0010855	adenylate cyclase inhibitor activity	Molecular Function	IDA[9473604]	1
GO:0008066	glutamate receptor activity	Molecular Function	IDA[9473604]	6
GO:0016021	integral to membrane	Cellular Component	IDA[12746871]	845
GO:0014050	negative regulation of glutamate secretion	Biological Process		3
GO:0007605	sensory perception of sound	Biological Process	IMP[19047183]	31
GO:0007268	synaptic transmission	Biological Process	IDA[9473604]	96
GO:0007614	short-term memory	Biological Process		2
GO:0007608	sensory perception of smell	Biological Process		19
GO:0001661	conditioned taste aversion	Biological Process		2
GO:0001642	group III metabotropic glutamate receptor activity	Molecular Function	IDA[9473604]	2

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04724	Glutamatergic synapse	43	Glutamate is the major excitatory neurotransmitter in the ma...... Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate. More...

Genes shared at least 5 GO terms with GRM7 (count: 30)

Gene Symbol	Pathway Count	Pathway List
GRIK1	7	adult behavior; presynaptic membrane; dendrite; postsynaptic membrane; integral to plasma membrane; plasma membrane; synaptic transmission;
DRD4	7	negative regulation of cAMP biosynthetic process; integral to plasma membrane; plasma membrane; negative regulation of adenylate cyclase activity; cell cortex; behavioral fear response; short-term memory;
GRM8	7	negative regulation of cAMP biosynthetic process; integral to plasma membrane; plasma membrane; negative regulation of adenylate cyclase activity; glutamate receptor activity; sensory perception of smell; group III metabotropic glutamate receptor activity;
GABRA5	7	dendrite; postsynaptic membrane; integral to plasma membrane; plasma membrane; behavioral fear response; sensory perception of sound; synaptic transmission;
NRXN1	6	adult behavior; presynaptic membrane; integral to plasma membrane; plasma membrane; calcium channel regulator activity; integral to membrane;
ADORA2A	6	asymmetric synapse; presynaptic membrane; postsynaptic membrane; presynaptic active zone; integral to plasma membrane; plasma membrane;
ACHE	6	presynaptic membrane; axon; dendrite; postsynaptic membrane; plasma membrane; synaptic transmission;
DRD2	6	axon; dendrite; integral to plasma membrane; plasma membrane; negative regulation of adenylate cyclase activity; sensory perception of smell;
SLC6A3	6	axon; integral to plasma membrane; plasma membrane; integral to membrane; synaptic transmission; sensory perception of smell;
PDE2A	5	negative regulation of cAMP biosynthetic process; presynaptic membrane; axon; dendrite; plasma membrane;
CHRM3	5	asymmetric synapse; dendrite; postsynaptic membrane; integral to plasma membrane; plasma membrane;
GRIK4	5	presynaptic membrane; postsynaptic membrane; integral to plasma membrane; plasma membrane; synaptic transmission;
GRIN2A	5	presynaptic membrane; postsynaptic membrane; integral to plasma membrane; plasma membrane; synaptic transmission;
SYT1	5	presynaptic membrane; plasma membrane; calcium ion binding; integral to membrane; synaptic transmission;
SLC1A3	5	glutamate binding; plasma membrane; integral to membrane; sensory perception of sound; synaptic transmission;
CADM1	5	PDZ domain binding; axon; dendrite; plasma membrane; integral to membrane;
GRID2	5	PDZ domain binding; postsynaptic membrane; integral to plasma membrane; plasma membrane; glutamate receptor activity;
HCN1	5	axon; dendrite; plasma membrane; integral to membrane; synaptic transmission;
SLC6A1	5	axon; integral to plasma membrane; plasma membrane; integral to membrane; synaptic transmission;
CHRNA3	5	dendrite; postsynaptic membrane; plasma membrane; integral to membrane; synaptic transmission;
CHRNA4	5	dendrite; postsynaptic membrane; plasma membrane; integral to membrane; synaptic transmission;
HTR6	5	dendrite; integral to plasma membrane; plasma membrane; negative regulation of glutamate secretion; synaptic transmission;
CACNA1C	5	dendritic shaft; plasma membrane; voltage-gated calcium channel activity; integral to membrane; synaptic transmission;
GRM5	5	dendritic shaft; integral to plasma membrane; plasma membrane; glutamate receptor activity; synaptic transmission;
CHRNB4	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; integral to membrane; synaptic transmission;
GABBR2	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; negative regulation of adenylate cyclase activity; synaptic transmission;
GABRB3	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; sensory perception of sound; synaptic transmission;
GRIN2B	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; behavioral fear response; synaptic transmission;
HTR3A	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; integral to membrane; synaptic transmission;
RYR1	5	integral to plasma membrane; plasma membrane; cell cortex; voltage-gated calcium channel activity; calcium ion binding;

Genes shared at least 2 KEGG pathways with GRM7 (count: 10)

Gene Symbol	Pathway Count	Pathway List
GRIA4	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIK1	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIK4	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN2A	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN2B	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN3A	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM1	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM5	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM6	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM8	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;

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Region: chr3:6811688..7783218 View in gBrowse