ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DRD2
Approved Name	dopamine receptor D2
Location	11q22-q23
Position	chr11:113280317-113346001, -
External Links	HGNC: 3023 Entrez Gene: 1813 Ensembl: ENSG00000149295 UCSC: uc001poa.3
No. of Studies	10 (significant: 3; non-significant: 7; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Gene related studies (count: 10)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Comings DE, 1991	The prevalence of the A1 allele of the Taq I polymorphism of DRD2 was significantly increased in patients with ADHD.	Significant
Rowe DC, 1999	They doubt that the DRD2 TaqI polymorphism influences symptoms of ADHD in childhood through their analysis.	Non-significant
Nyman ES, 2007	Association was observed in males only for three intronic DRD2 SNPs (rs1079727, rs1079595, rs1124491) and an SNP in the 3'-UTR (rs1800497), the DRD2 Taq1A RFLPThe DRD2 minor allelic haplotype gave evidence of association for males, being risk-conferring. No evidence of association was seen in the complete sample or in females .	Significant
Qian Q, 2007	Logistic Regression Analysis: P-value=0.774, OR=1.091, 95%CI=0.600-1.985. No evidence of association was seen.	Non-significant
Wang G. X., 2012	SNP rs6275 mapped to this gene showed no association with ADHD in this study.	Non-significant
Gizer IR, 2009	The results of the meta-analysis were statistically mixedDue to the magnitude of the observed heterogeneity, it is difficult to draw definitive conclusions regarding the association between childhood ADHD and the polymorphisms/gene.	Significant
Kustanovich V, 2004	No evidence for an association was found	Non-significant
Kirley A, 2002	No preferential transmission of alleles to ADHD children was observed	Non-significant
Brookes K, 2006	UNPHASED TDT P-value=0.0843, global P-value=0.679, WHAP TDT P_sum P-value=0.567, no SNP with nominal P-value<0.05 located in this gene	Non-significant
Huang YS, 2003	there was no significant difference in transmission rates between DRD2 TaqI A1 and A2 alleles	Non-significant

Gene related SNPs (count: 47)

Literature-origin SNPs (count: 10)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs4245149	Chr11:113338357(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)
rs6279	Chr11:113281073(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1(0/1/0)
rs6275	Chr11:113283477(Fwd)	downstream_gene_variant; synonymous_variant	2(0/2/0)
rs1079595	Chr11:113282669(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant	1(1/0/0)
rs1079727	Chr11:113289182(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0/0)
rs1799978	Chr11:113346351(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)
rs1800497	Chr11:113270828(Fwd)	downstream_gene_variant; missense_variant	2(2/0/0)
rs4350392	Chr11:113335717(Fwd)	intron_variant; nc_transcript_variant	1(1/0/0)
rs1124491	Chr11:113282090(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant	1(1/0/0)
rs2234689	Chr11:113278483(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant	1(0/1/0)

LD-proxies (count: 37)

rs_ID	Location	Functional Annotation
rs4586205	Chr11:113307129(Fwd)	intron_variant; nc_transcript_variant
rs2242592	Chr11:113279430(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs1124493	Chr11:113282295(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs2242591	Chr11:113279921(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs4648319	Chr11:113314363(Fwd)	intron_variant; nc_transcript_variant
rs11214607	Chr11:113312139(Fwd)	intron_variant; nc_transcript_variant
rs2440390	Chr11:113286878(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs2283265	Chr11:113285536(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs2075654	Chr11:113289066(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs2734836	Chr11:113291239(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1079597	Chr11:113296286(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs10891552	Chr11:113333671(Fwd)	intron_variant; nc_transcript_variant
rs6278	Chr11:113280724(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs1079594	Chr11:113282812(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs1076560	Chr11:113283688(Fwd)	downstream_gene_variant; intron_variant
rs4648317	Chr11:113331532(Fwd)	intron_variant; nc_transcript_variant
rs2471854	Chr11:113299639(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs10891551	Chr11:113332295(Fwd)	intron_variant; nc_transcript_variant
rs2471851	Chr11:113301069(Fwd)	intron_variant; nc_transcript_variant
rs4938019	Chr11:113341391(Fwd)	intron_variant; nc_transcript_variant
rs7103679	Chr11:113303674(Fwd)	intron_variant; nc_transcript_variant
rs11214611	Chr11:113330219(Fwd)	intron_variant; nc_transcript_variant
rs7350522	Chr11:113305203(Fwd)	intron_variant; nc_transcript_variant
rs1079596	Chr11:113296619(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs1125394	Chr11:113297185(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs1125393	Chr11:113297349(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs7122454	Chr11:113327468(Fwd)	intron_variant; nc_transcript_variant
rs2471857	Chr11:113298339(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs2245805	Chr11:113290699(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1124492	Chr11:113282275(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs1076562	Chr11:113296008(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs2002453	Chr11:113289298(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs2005313	Chr11:113290049(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs2734841	Chr11:113281776(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs6276	Chr11:113281397(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs11214602	Chr11:113277551(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs2734842	Chr11:113280274(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 3)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
DRD2_TaqI	point mutation		5 (1/4/0)
DRD2_exon7_Ser311Cys	point mutation	exon 7	1 (0/1/0)
DRD2_promoter_-241A>G	point mutation	promoter	1 (0/1/0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 97)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 97)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001669	acrosomal vesicle	Cellular Component		9
GO:0001963	synaptic transmission, dopaminergic	Biological Process		7
GO:0001975	response to amphetamine	Biological Process		16
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	Biological Process		1
GO:0002027	regulation of heart rate	Biological Process		5
GO:0002028	regulation of sodium ion transport	Biological Process		4
GO:0002031	G-protein coupled receptor internalization	Biological Process		6
GO:0002052	positive regulation of neuroblast proliferation	Biological Process		4
GO:0002092	positive regulation of receptor internalization	Biological Process		7
GO:0005515	protein binding	Molecular Function	IPI[10692483]	910
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	IC[2531656]; IDA[8413587]	220
GO:0006874	cellular calcium ion homeostasis	Biological Process	IC[7921596]	16
GO:0007194	negative regulation of adenylate cyclase activity	Biological Process	IDA[2531656]	10
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	Biological Process	IDA[2531656]	3
GO:0007243	intracellular protein kinase cascade	Biological Process	IDA[1331329]	19
GO:0007409	axonogenesis	Biological Process		14
GO:0007270	neuron-neuron synaptic transmission	Biological Process		1
GO:0007608	sensory perception of smell	Biological Process		19
GO:0007416	synapse assembly	Biological Process		6
GO:0007625	grooming behavior	Biological Process		3
GO:0007616	long-term memory	Biological Process		4
GO:0007628	adult walking behavior	Biological Process		8
GO:0007626	locomotory behavior	Biological Process		24
GO:0008104	protein localization	Biological Process		10
GO:0007631	feeding behavior	Biological Process		9
GO:0008285	negative regulation of cell proliferation	Biological Process		59
GO:0008144	drug binding	Molecular Function	IDA[8413587]	19
GO:0008542	visual learning	Biological Process		12
GO:0008306	associative learning	Biological Process		5
GO:0009636	response to toxin	Biological Process		15
GO:0009416	response to light stimulus	Biological Process		7
GO:0001666	response to hypoxia	Biological Process		34
GO:0001659	temperature homeostasis	Biological Process		4
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	Molecular Function	IDA[8301582]	3
GO:0048678	response to axon injury	Biological Process		3
GO:0048169	regulation of long-term neuronal synaptic plasticity	Biological Process		4
GO:0050482	arachidonic acid secretion	Biological Process	IDA[8301582]	7
GO:0048755	branching morphogenesis of a nerve	Biological Process		1
GO:0046676	negative regulation of insulin secretion	Biological Process		3
GO:0046488	phosphatidylinositol metabolic process	Biological Process		1
GO:0048149	behavioral response to ethanol	Biological Process		4
GO:0048148	behavioral response to cocaine	Biological Process		6
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway	Biological Process		1
GO:0043679	axon terminus	Cellular Component		6
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0045776	negative regulation of blood pressure	Biological Process		5
GO:0043278	response to morphine	Biological Process		9
GO:0043266	regulation of potassium ion transport	Biological Process		4
GO:0043666	regulation of phosphoprotein phosphatase activity	Biological Process		4
GO:0043473	pigmentation	Biological Process		4
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process		22
GO:1901386	negative regulation of voltage-gated calcium channel activity	Biological Process	IDA[7921596]	2
GO:0060124	positive regulation of growth hormone secretion	Biological Process		1
GO:0060134	prepulse inhibition	Biological Process		10
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	Biological Process	IGI[17194762]	3
GO:0060160	negative regulation of dopamine receptor signaling pathway	Biological Process		2
GO:0051584	regulation of dopamine uptake involved in synaptic transmission	Biological Process	IC[8301582]	4
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	Biological Process		2
GO:0051898	negative regulation of protein kinase B signaling cascade	Biological Process		6
GO:0051967	negative regulation of synaptic transmission, glutamatergic	Biological Process		5
GO:0050709	negative regulation of protein secretion	Biological Process	IDA[16839358]	5
GO:0051209	release of sequestered calcium ion into cytosol	Biological Process		9
GO:0051481	reduction of cytosolic calcium ion concentration	Biological Process		2
GO:0051482	elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	Biological Process	IDA[1331329]	5
GO:0030814	regulation of cAMP metabolic process	Biological Process	IDA[8666994]	2
GO:0030672	synaptic vesicle membrane	Cellular Component		15
GO:0030432	peristalsis	Biological Process		4
GO:0030425	dendrite	Cellular Component		46
GO:0030424	axon	Cellular Component		35
GO:0030336	negative regulation of cell migration	Biological Process		13
GO:0030139	endocytic vesicle	Cellular Component		12
GO:0021984	adenohypophysis development	Biological Process		3
GO:0021853	cerebral cortex GABAergic interneuron migration	Biological Process		3
GO:0016328	lateral plasma membrane	Cellular Component		8
GO:0016055	Wnt receptor signaling pathway	Biological Process		20
GO:0015459	potassium channel regulator activity	Molecular Function	NAS[12297500]	7
GO:0014854	response to inactivity	Biological Process		1
GO:0014069	postsynaptic density	Cellular Component		23
GO:0014059	regulation of dopamine secretion	Biological Process		6
GO:0010039	response to iron ion	Biological Process		3
GO:0042493	response to drug	Biological Process		68
GO:0043204	perikaryon	Cellular Component		12
GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	Biological Process		1
GO:0042417	dopamine metabolic process	Biological Process	IC[8301582]	5
GO:0040018	positive regulation of multicellular organism growth	Biological Process		6
GO:0042220	response to cocaine	Biological Process		11
GO:0035810	positive regulation of urine volume	Biological Process		3
GO:0035815	positive regulation of renal sodium excretion	Biological Process		3
GO:0035240	dopamine binding	Molecular Function		8
GO:0035255	ionotropic glutamate receptor binding	Molecular Function		6
GO:0034776	response to histamine	Biological Process	IDA[16839358]	3
GO:0035094	response to nicotine	Biological Process		6
GO:0032228	regulation of synaptic transmission, GABAergic	Biological Process		3
GO:0032922	circadian regulation of gene expression	Biological Process		6
GO:0031223	auditory behavior	Biological Process		2
GO:0032147	activation of protein kinase activity	Biological Process		5

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04540	Gap junction	27	Gap junctions contain intercellular channels that allow dire...... Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation. More...

Genes shared at least 5 GO terms with DRD2 (count: 53)

Gene Symbol	Pathway Count	Pathway List
DRD3	33	synaptic transmission, dopaminergic; response to amphetamine; G-protein coupled receptor internalization; protein binding; plasma membrane; integral to plasma membrane; cellular calcium ion homeostasis; negative regulation of adenylate cyclase activity; adenylate cyclase-inhibiting dopamine receptor signaling pathway; locomotory behavior; drug binding; visual learning; dopamine neurotransmitter receptor activity, coupled via Gi/Go; arachidonic acid secretion; behavioral response to cocaine; positive regulation of transcription from RNA polymerase II promoter; negative regulation of blood pressure; response to morphine; prepulse inhibition; negative regulation of dopamine receptor signaling pathway; regulation of dopamine uptake involved in synaptic transmission; negative regulation of protein kinase B signaling cascade; negative regulation of protein secretion; regulation of cAMP metabolic process; endocytic vesicle; regulation of dopamine secretion; response to drug; dopamine metabolic process; response to cocaine; positive regulation of renal sodium excretion; dopamine binding; response to histamine; circadian regulation of gene expression;
DRD1	20	synaptic transmission, dopaminergic; response to amphetamine; protein binding; plasma membrane; integral to plasma membrane; synapse assembly; grooming behavior; adult walking behavior; visual learning; temperature homeostasis; behavioral response to cocaine; prepulse inhibition; phospholipase C-activating dopamine receptor signaling pathway; regulation of dopamine uptake involved in synaptic transmission; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; peristalsis; cerebral cortex GABAergic interneuron migration; response to drug; dopamine metabolic process; dopamine binding;
DRD4	20	synaptic transmission, dopaminergic; response to amphetamine; protein binding; plasma membrane; integral to plasma membrane; cellular calcium ion homeostasis; negative regulation of adenylate cyclase activity; adenylate cyclase-inhibiting dopamine receptor signaling pathway; drug binding; dopamine neurotransmitter receptor activity, coupled via Gi/Go; arachidonic acid secretion; behavioral response to ethanol; behavioral response to cocaine; negative regulation of voltage-gated calcium channel activity; positive regulation of dopamine uptake involved in synaptic transmission; negative regulation of protein secretion; potassium channel regulator activity; dopamine metabolic process; dopamine binding; response to histamine;
SLC6A3	15	protein binding; plasma membrane; integral to plasma membrane; sensory perception of smell; locomotory behavior; drug binding; prepulse inhibition; axon; adenohypophysis development; response to iron ion; response to drug; positive regulation of multicellular organism growth; response to cocaine; dopamine binding; response to nicotine;
ADORA2A	12	synaptic transmission, dopaminergic; response to amphetamine; protein binding; plasma membrane; integral to plasma membrane; locomotory behavior; negative regulation of cell proliferation; prepulse inhibition; postsynaptic density; response to drug; positive regulation of urine volume; positive regulation of renal sodium excretion;
DRD5	10	synaptic transmission, dopaminergic; response to amphetamine; plasma membrane; integral to plasma membrane; cellular calcium ion homeostasis; associative learning; negative regulation of blood pressure; phospholipase C-activating dopamine receptor signaling pathway; response to cocaine; dopamine binding;
TH	10	synaptic transmission, dopaminergic; response to amphetamine; protein binding; locomotory behavior; response to light stimulus; response to hypoxia; pigmentation; dendrite; perikaryon; dopamine binding;
GRIN2A	9	response to amphetamine; protein binding; plasma membrane; integral to plasma membrane; protein localization; visual learning; postsynaptic density; response to drug; dopamine metabolic process;
OPRM1	9	protein binding; plasma membrane; integral to plasma membrane; negative regulation of adenylate cyclase activity; locomotory behavior; negative regulation of cell proliferation; behavioral response to ethanol; positive regulation of ERK1 and ERK2 cascade; reduction of cytosolic calcium ion concentration;
ADRA1B	8	response to amphetamine; plasma membrane; integral to plasma membrane; intracellular protein kinase cascade; locomotory behavior; visual learning; behavioral response to cocaine; response to morphine;
HTR1B	8	G-protein coupled receptor internalization; plasma membrane; integral to plasma membrane; drug binding; negative regulation of synaptic transmission, glutamatergic; regulation of dopamine secretion; response to drug; response to cocaine;
CNR1	8	plasma membrane; integral to plasma membrane; drug binding; negative regulation of blood pressure; response to morphine; response to cocaine; response to nicotine; regulation of synaptic transmission, GABAergic;
HTR2A	8	plasma membrane; integral to plasma membrane; drug binding; temperature homeostasis; negative regulation of synaptic transmission, glutamatergic; release of sequestered calcium ion into cytosol; regulation of dopamine secretion; response to drug;
SLC18A2	7	response to amphetamine; plasma membrane; integral to plasma membrane; locomotory behavior; drug binding; synaptic vesicle membrane; response to cocaine;
ARRB2	7	G-protein coupled receptor internalization; positive regulation of receptor internalization; protein binding; plasma membrane; adult walking behavior; positive regulation of ERK1 and ERK2 cascade; postsynaptic density;
MAGI2	7	positive regulation of receptor internalization; protein binding; plasma membrane; negative regulation of cell proliferation; negative regulation of protein kinase B signaling cascade; negative regulation of cell migration; postsynaptic density;
SNCA	7	protein binding; plasma membrane; regulation of long-term neuronal synaptic plasticity; behavioral response to cocaine; axon; regulation of dopamine secretion; response to drug;
RYR2	6	regulation of heart rate; protein binding; plasma membrane; cellular calcium ion homeostasis; response to hypoxia; release of sequestered calcium ion into cytosol;
ADRB2	6	regulation of sodium ion transport; protein binding; plasma membrane; integral to plasma membrane; positive regulation of transcription from RNA polymerase II promoter; potassium channel regulator activity;
VEGFA	6	positive regulation of neuroblast proliferation; positive regulation of receptor internalization; protein binding; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; activation of protein kinase activity;
ADRA2A	6	protein binding; plasma membrane; integral to plasma membrane; negative regulation of adenylate cyclase activity; negative regulation of insulin secretion; activation of protein kinase activity;
MC1R	6	protein binding; plasma membrane; integral to plasma membrane; intracellular protein kinase cascade; positive regulation of transcription from RNA polymerase II promoter; pigmentation;
NRXN1	6	protein binding; plasma membrane; integral to plasma membrane; pigmentation; prepulse inhibition; endocytic vesicle;
PTPRJ	6	protein binding; plasma membrane; integral to plasma membrane; negative regulation of cell proliferation; negative regulation of protein kinase B signaling cascade; negative regulation of cell migration;
PTPRK	6	protein binding; integral to plasma membrane; negative regulation of cell proliferation; dendrite; axon; negative regulation of cell migration;
SLC6A4	6	protein binding; plasma membrane; integral to plasma membrane; response to toxin; response to hypoxia; response to drug;
ADRA1A	6	plasma membrane; integral to plasma membrane; intracellular protein kinase cascade; negative regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; response to drug;
CHRNA4	6	plasma membrane; locomotory behavior; response to hypoxia; dendrite; regulation of dopamine secretion; response to nicotine;
EDNRA	6	plasma membrane; integral to plasma membrane; response to hypoxia; response to morphine; positive regulation of ERK1 and ERK2 cascade; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;
GRM7	6	plasma membrane; integral to plasma membrane; negative regulation of adenylate cyclase activity; sensory perception of smell; dendrite; axon;
OXTR	5	response to amphetamine; plasma membrane; integral to plasma membrane; response to drug; response to cocaine;
ARRB1	5	G-protein coupled receptor internalization; protein binding; plasma membrane; positive regulation of transcription from RNA polymerase II promoter; positive regulation of ERK1 and ERK2 cascade;
ACHE	5	protein binding; plasma membrane; synapse assembly; dendrite; axon;
ADAM17	5	protein binding; plasma membrane; integral to plasma membrane; response to hypoxia; response to drug;
ADRB1	5	protein binding; plasma membrane; integral to plasma membrane; drug binding; dopamine binding;
ANK3	5	protein binding; plasma membrane; axonogenesis; regulation of potassium ion transport; lateral plasma membrane;
APC	5	protein binding; plasma membrane; axonogenesis; negative regulation of cell proliferation; lateral plasma membrane;
CACNA1C	5	protein binding; plasma membrane; adult walking behavior; visual learning; postsynaptic density;
CADM1	5	protein binding; plasma membrane; synapse assembly; dendrite; axon;
FLCN	5	protein binding; plasma membrane; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein kinase B signaling cascade; negative regulation of cell migration;
GHR	5	protein binding; plasma membrane; integral to plasma membrane; response to morphine; positive regulation of multicellular organism growth;
GSK3B	5	protein binding; plasma membrane; positive regulation of transcription from RNA polymerase II promoter; response to drug; ionotropic glutamate receptor binding;
HTR6	5	protein binding; plasma membrane; integral to plasma membrane; dendrite; response to drug;
LPAR1	5	protein binding; plasma membrane; integral to plasma membrane; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; endocytic vesicle;
PAK1	5	protein binding; plasma membrane; response to hypoxia; dendrite; axon;
PDE2A	5	protein binding; plasma membrane; drug binding; dendrite; axon;
PRKD1	5	protein binding; plasma membrane; integral to plasma membrane; intracellular protein kinase cascade; positive regulation of transcription from RNA polymerase II promoter;
THY1	5	protein binding; plasma membrane; integral to plasma membrane; dendrite; negative regulation of cell migration;
TLR4	5	protein binding; plasma membrane; integral to plasma membrane; positive regulation of transcription from RNA polymerase II promoter; positive regulation of ERK1 and ERK2 cascade;
CHRM1	5	plasma membrane; integral to plasma membrane; drug binding; axon terminus; postsynaptic density;
CHRM3	5	plasma membrane; integral to plasma membrane; drug binding; axon terminus; dendrite;
HTR2C	5	plasma membrane; feeding behavior; drug binding; release of sequestered calcium ion into cytosol; response to drug;
SLC6A1	5	plasma membrane; integral to plasma membrane; response to toxin; axon; response to cocaine;

Genes shared at least 2 KEGG pathways with DRD2 (count: 7)

Gene Symbol	Pathway Count	Pathway List
ADRB1	2	Neuroactive ligand-receptor interaction; Gap junction;
DRD1	2	Neuroactive ligand-receptor interaction; Gap junction;
GRM1	2	Neuroactive ligand-receptor interaction; Gap junction;
GRM5	2	Neuroactive ligand-receptor interaction; Gap junction;
HTR2A	2	Neuroactive ligand-receptor interaction; Gap junction;
HTR2C	2	Neuroactive ligand-receptor interaction; Gap junction;
LPAR1	2	Neuroactive ligand-receptor interaction; Gap junction;

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Region: chr11:113280317..113346001 View in gBrowse