ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs6275 dbSNP Ensembl
Location	chr11:113283477(Fwd)
Variant Alleles	A/G
Ancestral Allele	G
Functional Annotation	downstream_gene_variant; synonymous_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000535984; ENST00000539420; ENST00000540600; ENST00000543292; ENST00000546284) synonymous_variant(ENST00000346454; ENST00000355319; ENST00000362072; ENST00000538967; ENST00000542968; ENST00000544518)
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Wang G. X., 2012	T/C	T	Chi-square test: genotypic p>0.05; allelic p>0.05 Chi-square test: genotypic p>0.05; allelic p>0.05	The genotype distribution and allele frequencies of this SNP...... The genotype distribution and allele frequencies of this SNP showed no significant difference between ADHD children and healthy controls. More...	Non-significant
Nyman ES, 2007			No available information. No available information.	No evidence of association was seen. No evidence of association was seen.	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DRD2	dopamine receptor D2	11q22-q23	10(3/7/0)

Genes from other sources (count: 0)

SNPs in LD with rs6275 (count: 27) View in gBrowse (chr11:113247232..113307129 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 27)

rs_ID	Functional Annotation	r²[population]
rs12224538	intron_variant; upstream_gene_variant	0.826[JPT]
rs2242592	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[TSI]; 0.881[ASW]; 0.954[CHB]; 1.0[CHD]; 1.0[JPT]; 0.886[GIH]; 1.0[MEX]
rs4938011	downstream_gene_variant; intron_variant	0.803[CHD]
rs1124492	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	0.888[CHD]; 0.867[JPT]
rs2734842	downstream_gene_variant; intron_variant; nc_transcript_variant	0.951[CEU]; 0.954[CHB]; 1.0[JPT]
rs4938014	intron_variant; NMD_transcript_variant	0.885[CHD]; 0.826[JPT]
rs6276	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.955[CEU]; 0.954[CHB]; 1.0[JPT]
rs1076562	intron_variant; nc_transcript_variant; upstream_gene_variant	0.807[TSI]; 0.907[CHB]; 0.828[CHD]; 0.861[JPT]; 0.869[GIH]
rs4590907	intron_variant; upstream_gene_variant	0.884[CHD]; 0.826[JPT]
rs2245805	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.807[TSI]; 0.907[CHB]; 0.828[CHD]; 0.861[JPT]; 0.869[GIH]
rs2587550	downstream_gene_variant; upstream_gene_variant	0.957[CEU]; 1.0[TSI]; 0.954[CHB]; 1.0[CHD]; 1.0[JPT]; 0.886[GIH]; 0.898[MEX]
rs2734841	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 0.953[CHB]; 1.0[JPT]
rs4586205	intron_variant; nc_transcript_variant	0.861[JPT]
rs1076560	downstream_gene_variant; intron_variant	0.813[CHD]
rs2859545	downstream_gene_variant; upstream_gene_variant	0.952[CEU]; 0.952[CHB]; 1.0[JPT]
rs6278	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.909[CHD]
rs11214602	downstream_gene_variant; intron_variant; nc_transcript_variant	0.949[CHB]; 1.0[JPT]
rs10891541	intron_variant	0.86[JPT]
rs1124493	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	1.0[CEU]; 1.0[TSI]; 1.0[ASW]; 0.954[CHB]; 1.0[CHD]; 1.0[JPT]; 0.886[GIH]; 0.971[LWK]; 1.0[MEX]; 0.933[MKK]; 1.0[YRI]
rs11214598	intron_variant; NMD_transcript_variant	0.877[CEU]; 0.944[TSI]; 0.911[CHB]; 0.977[CHD]; 0.953[JPT]; 0.863[GIH]
rs2005313	intron_variant; nc_transcript_variant; upstream_gene_variant	0.904[CHB]; 0.861[JPT]
rs2002453	intron_variant; nc_transcript_variant; upstream_gene_variant	0.807[TSI]; 0.907[CHB]; 0.828[CHD]; 0.861[JPT]; 0.869[GIH]
rs10891545	downstream_gene_variant; upstream_gene_variant	0.868[CHD]; 0.826[JPT]
rs7118900	3_prime_UTR_variant; missense_variant; NMD_transcript_variant	0.888[CHD]
rs2242591	downstream_gene_variant; intron_variant; nc_transcript_variant	0.819[CHB]; 0.943[JPT]
rs1003641	downstream_gene_variant; upstream_gene_variant	1.0[CEU]; 1.0[TSI]; 0.954[CHB]; 1.0[CHD]; 1.0[JPT]; 0.842[GIH]; 0.946[MEX]
rs4938016	downstream_gene_variant; missense_variant	0.955[CEU]; 0.911[CHB]; 0.953[JPT]