ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol DRD3
Approved Name dopamine receptor D3
Location 3q13.3
Position chr3:113847499-113918254, -1
External Links HGNC: 3024
Entrez Gene: 1814
Ensembl: ENSG00000151577
UCSC: uc003ebc.1
No. of Studies 8 (significant: 1; non-significant: 7; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 8)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Brookes K, 2006 UNPHASED TDT P-value=0.0959, global P-value=0.828, WHAP TDT P_sum P-value=0.653, no SNP with nominal P-value<0.05 located in this gene Non-significant
Gizer IR, 2009 The present study does not support a relation between ADHD and this gene. Non-significant
Guan L, 2009 haplotype association analysis: Nominal P-value=0.037, Empirical P-value=0.293 for ADHD-C. 1 SNP in this gene achieved nominal significance for ADHD-C, and haplotype association test also achieved nominal significance for ADHD-C. Significant
Barr CL, 2000 (d) TDT of haplotypes: smallest P=0.317. No significant evidence for either allele of the MscI or MspI polymorphisms or for the haplotypes of these two polymorphisms. Non-significant
Nyman ES, 2007 No evidence of association was seen. Non-significant
Payton A, 2001 there was no evidence of preferential transmission of any marker allele for the polymorphism examined in this study Non-significant
Kirley A, 2002 No preferential transmission of alleles to ADHD children was observed Non-significant
Muglia P, 2002 Result from this study suggests that DRD3 is not playing a major role in the sample of adult ADHD Non-significant

Gene related SNPs (count: 40)

Literature-origin SNPs (count: 7)

LD-proxies (count: 33)

Gene related CNVs (count: 0)

Gene related other variant (count: 2)

Gene related regions (count: 0)

Gene related GO terms (count: 55)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 55)

Gene related KEGG pathways (count: 1)

Genes shared at least 5 GO terms with DRD3 (count: 38)

Genes shared at least 2 KEGG pathways with DRD3 (count: 0)

View in gBrowse

Region: chr3:113847499..113918254 View in gBrowse
View in gBrowse