ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	EDNRA
Approved Name	endothelin receptor type A
Location	4q31.22
Position	chr4:148402069-148466106, 1
External Links	HGNC: 3179 Entrez Gene: 1909 Ensembl: ENSG00000151617 UCSC: uc003iky.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 49)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 49)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001934	positive regulation of protein phosphorylation	biological process	IEA	24
GO:0060322	head development	biological process	IEA	3
GO:0007202	activation of phospholipase C activity	biological process	TAS[8702836]	15
GO:0019233	sensory perception of pain	biological process	IEA	18
GO:0030818	negative regulation of cAMP biosynthetic process	biological process	IEA	7
GO:0001569	patterning of blood vessels	biological process	IEA	8
GO:0014032	neural crest cell development	biological process	IEA	2
GO:0008283	cell proliferation	biological process	NAS[9284755]	66
GO:0016020	membrane	cellular component	NAS	155
GO:0032496	response to lipopolysaccharide	biological process	IEA	23
GO:0071260	cellular response to mechanical stimulus	biological process	IEA	14
GO:0001821	histamine secretion	biological process	IEA	1
GO:0007204	elevation of cytosolic calcium ion concentration	biological process	TAS[1849646]	21
GO:0015758	glucose transport	biological process	ISS	14
GO:0050729	positive regulation of inflammatory response	biological process	IEA	9
GO:0001666	response to hypoxia	biological process	IEA	41
GO:0007165	signal transduction	biological process	TAS[1326535]	189
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	biological process	IEA	10
GO:0005887	integral to plasma membrane	cellular component	TAS[1326535]	236
GO:0007266	Rho protein signal transduction	biological process	IEA	12
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IEA	23
GO:0007585	respiratory gaseous exchange	biological process	ISS	5
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0006939	smooth muscle contraction	biological process	NAS[9284755]	10
GO:0001701	in utero embryonic development	biological process	IEA	39
GO:0030315	T-tubule	cellular component	IEA	12
GO:0042310	vasoconstriction	biological process	IMP[8982507]	2
GO:0048144	fibroblast proliferation	biological process	IEA	1
GO:0008284	positive regulation of cell proliferation	biological process	IEA	75
GO:0003094	glomerular filtration	biological process	IEA	2
GO:0031965	nuclear membrane	cellular component	IEA	27
GO:0090184	positive regulation of kidney development	biological process	IEA	3
GO:0007186	G-protein coupled receptor signaling pathway	biological process	NAS[8611157]	77
GO:0048659	smooth muscle cell proliferation	biological process	IEA	1
GO:0043066	negative regulation of apoptotic process	biological process	IEA	85
GO:0050678	regulation of epithelial cell proliferation	biological process	IEA	2
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	biological process	IEA	5
GO:0004435	phosphatidylinositol phospholipase C activity	molecular function	TAS[8702836]	20
GO:0043084	penile erection	biological process	IEA	1
GO:0060137	maternal process involved in parturition	biological process	IEA	2
GO:0042482	positive regulation of odontogenesis	biological process	IEA	1
GO:0007190	activation of adenylate cyclase activity	biological process	TAS[8702836]	10
GO:0051482	elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	biological process	IEA	5
GO:0014824	artery smooth muscle contraction	biological process	IMP[8982507]	1
GO:0007568	aging	biological process	IEA	29
GO:0043278	response to morphine	biological process	IEA	9
GO:0090023	positive regulation of neutrophil chemotaxis	biological process	IEA	5
GO:0004962	endothelin receptor activity	molecular function	NAS[8611157]	1
GO:0007507	heart development	biological process	IEA	29

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	89
hsa04020	Calcium signaling pathway	66

Genes shared at least 5 GO terms with EDNRA (count: 38)

Gene Symbol	Pathway Count	Pathway List
ADRA1A	11	activation of phospholipase C activity; elevation of cytosolic calcium ion concentration; signal transduction; integral to plasma membrane; positive regulation of ERK1 and ERK2 cascade; plasma membrane; smooth muscle contraction; T-tubule; nuclear membrane; G-protein coupled receptor signaling pathway; aging;
CHRM1	9	cell proliferation; membrane; signal transduction; protein kinase C-activating G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; positive regulation of cell proliferation; G-protein coupled receptor signaling pathway; phosphatidylinositol phospholipase C activity;
VEGFA	7	positive regulation of protein phosphorylation; patterning of blood vessels; membrane; response to hypoxia; in utero embryonic development; positive regulation of cell proliferation; negative regulation of apoptotic process;
ADRA2A	7	negative regulation of cAMP biosynthetic process; signal transduction; integral to plasma membrane; Rho protein signal transduction; plasma membrane; positive regulation of cell proliferation; G-protein coupled receptor signaling pathway;
CHRM3	7	cell proliferation; signal transduction; integral to plasma membrane; plasma membrane; smooth muscle contraction; G-protein coupled receptor signaling pathway; phosphatidylinositol phospholipase C activity;
BDKRB2	7	elevation of cytosolic calcium ion concentration; integral to plasma membrane; plasma membrane; smooth muscle contraction; G-protein coupled receptor signaling pathway; negative regulation of apoptotic process; phosphatidylinositol phospholipase C activity;
ADAM17	6	positive regulation of protein phosphorylation; response to lipopolysaccharide; response to hypoxia; integral to plasma membrane; plasma membrane; positive regulation of cell proliferation;
FLT4	6	positive regulation of protein phosphorylation; integral to plasma membrane; positive regulation of ERK1 and ERK2 cascade; plasma membrane; positive regulation of cell proliferation; negative regulation of apoptotic process;
LPAR1	6	activation of phospholipase C activity; elevation of cytosolic calcium ion concentration; integral to plasma membrane; plasma membrane; G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;
ADRB1	6	sensory perception of pain; integral to plasma membrane; Rho protein signal transduction; plasma membrane; activation of adenylate cyclase activity; aging;
HTR2A	6	sensory perception of pain; integral to plasma membrane; plasma membrane; positive regulation of cell proliferation; phosphatidylinositol phospholipase C activity; aging;
CNR1	6	sensory perception of pain; response to lipopolysaccharide; integral to plasma membrane; plasma membrane; aging; response to morphine;
CCKBR	6	cell proliferation; elevation of cytosolic calcium ion concentration; integral to plasma membrane; plasma membrane; positive regulation of cell proliferation; phosphatidylinositol phospholipase C activity;
PLCE1	6	cell proliferation; elevation of cytosolic calcium ion concentration; protein kinase C-activating G-protein coupled receptor signaling pathway; plasma membrane; phosphatidylinositol phospholipase C activity; heart development;
ADRA1B	6	cell proliferation; integral to plasma membrane; plasma membrane; nuclear membrane; G-protein coupled receptor signaling pathway; response to morphine;
CXCR2	6	membrane; elevation of cytosolic calcium ion concentration; signal transduction; integral to plasma membrane; plasma membrane; positive regulation of cell proliferation;
TLR4	6	response to lipopolysaccharide; cellular response to mechanical stimulus; positive regulation of inflammatory response; integral to plasma membrane; positive regulation of ERK1 and ERK2 cascade; plasma membrane;
C3AR1	6	elevation of cytosolic calcium ion concentration; integral to plasma membrane; plasma membrane; G-protein coupled receptor signaling pathway; phosphatidylinositol phospholipase C activity; positive regulation of neutrophil chemotaxis;
DRD2	6	response to hypoxia; integral to plasma membrane; positive regulation of ERK1 and ERK2 cascade; plasma membrane; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; response to morphine;
TGFBR1	6	signal transduction; plasma membrane; in utero embryonic development; positive regulation of cell proliferation; negative regulation of apoptotic process; heart development;
FGF4	5	positive regulation of protein phosphorylation; signal transduction; positive regulation of ERK1 and ERK2 cascade; positive regulation of cell proliferation; negative regulation of apoptotic process;
ERBB2	5	positive regulation of protein phosphorylation; cell proliferation; signal transduction; plasma membrane; heart development;
ADRBK1	5	activation of phospholipase C activity; membrane; signal transduction; plasma membrane; heart development;
MS4A2	5	activation of phospholipase C activity; cell proliferation; protein kinase C-activating G-protein coupled receptor signaling pathway; integral to plasma membrane; G-protein coupled receptor signaling pathway;
CHRNA4	5	sensory perception of pain; membrane; response to hypoxia; signal transduction; plasma membrane;
OPRM1	5	sensory perception of pain; elevation of cytosolic calcium ion concentration; integral to plasma membrane; positive regulation of ERK1 and ERK2 cascade; plasma membrane;
HTR1B	5	negative regulation of cAMP biosynthetic process; protein kinase C-activating G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; G-protein coupled receptor signaling pathway;
ADRA1D	5	cell proliferation; integral to plasma membrane; plasma membrane; positive regulation of cell proliferation; G-protein coupled receptor signaling pathway;
HTR4	5	membrane; integral to plasma membrane; plasma membrane; positive regulation of cell proliferation; G-protein coupled receptor signaling pathway;
PIK3CG	5	membrane; elevation of cytosolic calcium ion concentration; plasma membrane; G-protein coupled receptor signaling pathway; negative regulation of apoptotic process;
ADORA2A	5	membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; activation of adenylate cyclase activity;
SNCA	5	response to lipopolysaccharide; plasma membrane; negative regulation of apoptotic process; positive regulation of release of sequestered calcium ion into cytosol; aging;
IL6	5	response to lipopolysaccharide; positive regulation of ERK1 and ERK2 cascade; positive regulation of cell proliferation; negative regulation of apoptotic process; aging;
CCR5	5	elevation of cytosolic calcium ion concentration; integral to plasma membrane; plasma membrane; G-protein coupled receptor signaling pathway; phosphatidylinositol phospholipase C activity;
OXTR	5	elevation of cytosolic calcium ion concentration; integral to plasma membrane; plasma membrane; maternal process involved in parturition; heart development;
S1PR3	5	elevation of cytosolic calcium ion concentration; integral to plasma membrane; plasma membrane; positive regulation of cell proliferation; G-protein coupled receptor signaling pathway;
DRD3	5	integral to plasma membrane; plasma membrane; positive regulation of cell proliferation; G-protein coupled receptor signaling pathway; response to morphine;
DRD1	5	integral to plasma membrane; plasma membrane; positive regulation of release of sequestered calcium ion into cytosol; activation of adenylate cyclase activity; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;

Genes shared at least 2 KEGG pathways with EDNRA (count: 28)

Gene Symbol	Pathway Count	Pathway List
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr4:148402069..148466106 View in gBrowse