ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CCR5
Previous Symbol	CMKBR5
Symbol Alias	CKR-5, CC-CKR-5, CKR5, CD195, IDDM22
Approved Name	chemokine (C-C motif) receptor 5
Location	3p21
Position	chr3:46411633-46417697, +
External Links	HGNC: 1606 Entrez Gene: 1234 Ensembl: ENSG00000160791 UCSC: uc003cpo.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 35)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016032	viral reproduction	Biological Process		57
GO:0015026	coreceptor activity	Molecular Function	TAS[10469138]	4
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Biological Process	IDA[19523456]	4
GO:0009986	cell surface	Cellular Component	IDA[10521508]	70
GO:0009897	external side of plasma membrane	Cellular Component	IDA[11278962]	34
GO:0007267	cell-cell signaling	Biological Process	IDA[10679098]	38
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	TAS[10201901]	20
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	IMP[19523456]	72
GO:0007166	cell surface receptor signaling pathway	Biological Process	TAS[8639485]	35
GO:0006968	cellular defense response	Biological Process	TAS[10201901]	12
GO:0006955	immune response	Biological Process	TAS[8639485]	45
GO:0006954	inflammatory response	Biological Process	TAS[8639485]	51
GO:0006935	chemotaxis	Biological Process	TAS[10741397]	15
GO:0006816	calcium ion transport	Biological Process	IDA[8699119]	32
GO:0005887	integral to plasma membrane	Cellular Component	TAS[10393923]	220
GO:0005768	endosome	Cellular Component	IDA[10679098]	27
GO:0005886	plasma membrane	Cellular Component		772
GO:0005515	protein binding	Molecular Function	IPI[15001559]	910
GO:0005737	cytoplasm	Cellular Component	TAS[10415069]	690
GO:0004435	phosphatidylinositol phospholipase C activity	Molecular Function	TAS[8663314]	20
GO:0004950	chemokine receptor activity	Molecular Function	TAS[10201901]	2
GO:0002407	dendritic cell chemotaxis	Biological Process	TAS[16621978]	5
GO:0003779	actin binding	Molecular Function	IDA[12421915]	46
GO:0000165	MAPK cascade	Biological Process	IEP[12032188]	10
GO:0071222	cellular response to lipopolysaccharide	Biological Process	IEP[10679098]	13
GO:0071791	chemokine (C-C motif) ligand 5 binding	Molecular Function	IPI[8699119]	1
GO:0023052	signaling	Biological Process	IEP[12032188]	1
GO:0030260	entry into host cell	Biological Process		1
GO:0070098	chemokine-mediated signaling pathway	Biological Process	TAS[10201901]	3
GO:0070723	response to cholesterol	Biological Process	IMP[19523456]	2
GO:0016493	C-C chemokine receptor activity	Molecular Function	IDA[11278962]; NAS[8639485]	1
GO:0019048	virus-host interaction	Biological Process		54
GO:0019722	calcium-mediated signaling	Biological Process	IDA[19523456]	7
GO:0019957	C-C chemokine binding	Molecular Function	IPI[8699119]	1

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa05145	Toxoplasmosis	33	Toxoplasma gondii is an obligate intracellular parasite that...... Toxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechanisms. During early infection, nuclear translocation of NFkB is temporally blocked and p38 MAPK phosphorylation is prevented, suppressing IL-12 production. Another pathway for IL-12 induction occurs through CCR5 dependent pathway, but parasitic induction of an eicosanoid LXA4 contributes to the downregulation of IL-12. Direct activation of STAT3 by the parasite enhance anti-inflammatory function of IL-10 and TGF beta. T. gondii can cause lifelong chronic infection by establishing an anti-apoptotic environment through induction of bcl-2 or IAPs and by redirecting LDL-mediated cholesterol transport to scavenge nutrients from the host. More...

Genes shared at least 5 GO terms with CCR5 (count: 42)

Gene Symbol	Pathway Count	Pathway List
BDKRB2	10	lipase activity; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; cell surface receptor signaling pathway; inflammatory response; integral to plasma membrane; endosome; plasma membrane; protein binding; phosphatidylinositol phospholipase C activity;
CXCR2	9	cell surface; elevation of cytosolic calcium ion concentration; cell surface receptor signaling pathway; cellular defense response; inflammatory response; chemotaxis; integral to plasma membrane; plasma membrane; dendritic cell chemotaxis;
C3AR1	8	lipase activity; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response; chemotaxis; integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity;
SPN	8	cell surface; external side of plasma membrane; cell surface receptor signaling pathway; cellular defense response; immune response; chemotaxis; integral to plasma membrane; plasma membrane;
CXCR1	8	G-protein coupled receptor signaling pathway; cell surface receptor signaling pathway; inflammatory response; chemotaxis; plasma membrane; chemokine receptor activity; dendritic cell chemotaxis; chemokine-mediated signaling pathway;
PLCE1	7	lipase activity; elevation of cytosolic calcium ion concentration; plasma membrane; protein binding; cytoplasm; phosphatidylinositol phospholipase C activity; calcium-mediated signaling;
TLR4	7	external side of plasma membrane; immune response; integral to plasma membrane; plasma membrane; protein binding; cytoplasm; cellular response to lipopolysaccharide;
ADRA2C	7	cell-cell signaling; G-protein coupled receptor signaling pathway; integral to plasma membrane; endosome; plasma membrane; protein binding; cytoplasm;
PIK3CG	7	elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response; plasma membrane; protein binding; cytoplasm; dendritic cell chemotaxis;
CASR	6	lipase activity; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; protein binding; phosphatidylinositol phospholipase C activity;
CCKBR	6	lipase activity; elevation of cytosolic calcium ion concentration; cell surface receptor signaling pathway; integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity;
EDNRA	6	lipase activity; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity;
ADAM8	6	cell surface; inflammatory response; integral to plasma membrane; plasma membrane; protein binding; cytoplasm;
LPAR1	6	cell surface; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; protein binding;
ADORA2A	6	cell-cell signaling; cellular defense response; inflammatory response; integral to plasma membrane; plasma membrane; protein binding;
ADRA2B	6	cell-cell signaling; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; protein binding; MAPK cascade;
RELA	6	cellular defense response; inflammatory response; protein binding; cytoplasm; cellular response to lipopolysaccharide; virus-host interaction;
CHRM1	5	lipase activity; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity;
CHRM3	5	lipase activity; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity;
F2RL2	5	lipase activity; integral to plasma membrane; plasma membrane; protein binding; phosphatidylinositol phospholipase C activity;
RYR1	5	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; calcium ion transport; integral to plasma membrane; plasma membrane; cytoplasm;
RYR2	5	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; calcium ion transport; plasma membrane; protein binding; calcium-mediated signaling;
ADAM17	5	cell surface; integral to plasma membrane; plasma membrane; protein binding; cytoplasm;
FZD4	5	cell surface; integral to plasma membrane; plasma membrane; protein binding; cytoplasm;
ITGA2	5	cell surface; external side of plasma membrane; plasma membrane; protein binding; virus-host interaction;
MIF	5	cell surface; cell surface receptor signaling pathway; inflammatory response; protein binding; cytoplasm;
SCARB1	5	cell surface; integral to plasma membrane; plasma membrane; cytoplasm; virus-host interaction;
SORT1	5	cell surface; G-protein coupled receptor signaling pathway; endosome; plasma membrane; cytoplasm;
CD3E	5	external side of plasma membrane; G-protein coupled receptor signaling pathway; cell surface receptor signaling pathway; integral to plasma membrane; plasma membrane;
CXCL12	5	external side of plasma membrane; G-protein coupled receptor signaling pathway; immune response; chemotaxis; chemokine-mediated signaling pathway;
IL7R	5	external side of plasma membrane; cell surface receptor signaling pathway; immune response; plasma membrane; protein binding;
MS4A2	5	external side of plasma membrane; G-protein coupled receptor signaling pathway; inflammatory response; integral to plasma membrane; endosome;
ADRA1A	5	cell-cell signaling; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane;
S1PR3	5	elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response; integral to plasma membrane; plasma membrane;
ABCA1	5	G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; protein binding; cellular response to lipopolysaccharide;
ADRA2A	5	G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; protein binding; cytoplasm;
HTR4	5	G-protein coupled receptor signaling pathway; integral to plasma membrane; endosome; plasma membrane; cytoplasm;
LTB4R	5	G-protein coupled receptor signaling pathway; immune response; inflammatory response; integral to plasma membrane; plasma membrane;
ADRB2	5	cell surface receptor signaling pathway; integral to plasma membrane; endosome; plasma membrane; protein binding;
PRKD1	5	inflammatory response; integral to plasma membrane; plasma membrane; protein binding; cytoplasm;
MAPK1	5	chemotaxis; protein binding; cytoplasm; MAPK cascade; virus-host interaction;
ARPC2	5	endosome; plasma membrane; protein binding; cytoplasm; actin binding;

Genes shared at least 2 KEGG pathways with CCR5 (count: 21)

Gene Symbol	Pathway Count	Pathway List
CXCR1	3	Endocytosis; Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR2	3	Endocytosis; Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
ADRBK1	2	Endocytosis; Chemokine signaling pathway;
ADRBK2	2	Endocytosis; Chemokine signaling pathway;
ARRB1	2	Endocytosis; Chemokine signaling pathway;
ARRB2	2	Endocytosis; Chemokine signaling pathway;
HSPA6	2	Endocytosis; Toxoplasmosis;
HSPA8	2	Endocytosis; Toxoplasmosis;
TGFBR1	2	Endocytosis; Cytokine-cytokine receptor interaction;
CCL19	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CCL27	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCL12	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR5	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
MAPK1	2	Chemokine signaling pathway; Toxoplasmosis;
MAPK3	2	Chemokine signaling pathway; Toxoplasmosis;
PIK3CG	2	Chemokine signaling pathway; Toxoplasmosis;
PIK3R1	2	Chemokine signaling pathway; Toxoplasmosis;
RELA	2	Chemokine signaling pathway; Toxoplasmosis;
IFNGR1	2	Cytokine-cytokine receptor interaction; Toxoplasmosis;
IL10RA	2	Cytokine-cytokine receptor interaction; Toxoplasmosis;
IL12B	2	Cytokine-cytokine receptor interaction; Toxoplasmosis;

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Region: chr3:46411633..46417697 View in gBrowse