ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol ADRA2A
Previous Symbol ADRA2, ADRA2R
Symbol Alias ADRAR
Approved Name adrenoceptor alpha 2A
Previous Name "adrenergic, alpha-2A-, receptor"
Name Alias "alpha-2AAR subtype C10", " alpha-2A-adrenergic receptor"
Location 10q25.2
Position chr10:112836790-112840658, 1
External Links HGNC: 281
Entrez Gene: 150
Ensembl: ENSG00000150594
UCSC: uc001kzo.3
No. of Studies 13 (significant: 4; non-significant: 9; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 13)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Bobb AJ, 2005 no polymorphism was associated with ADHD Non-significant
Brookes K, 2006 UNPHASED TDT P-value=0.141, global P-value=0.505, WHAP TDT P_sum P-value=0.88, no SNP with nominal P-value<0.05 located in this gene Non-significant
de Cerqueira CC, 2011 chi-square test P-value=0.080, X2=5.044 for three-marker haplotype frequencies, which showed no significant differences between patients and controls Non-significant
Gizer IR, 2009 The present study does not support a relation between ADHD and this gene. Non-significant
Hawi, Z., 2012 This gene did not show significant association with ADHD. Non-significant
Roman T, 2003 there was no evidence of association between the ADRA2A MspI variant and the disorder, but effects of the ADRA2A gene on inattention and combined symptom scores were detected Non-significant
Shiffrin ND, 2013 No significant or Trend associated SNP was mapped in this gene. Non-significant
Wang B, 2006 haplotype M (C allele)/C of MspI/DraI, P-value=0.072, X2 (1df)=3.233 with the ADHD-C subtype; weak evidence for a possible role of ADRA2A Non-significant
Xu C, 2001 no evidence for linkage of the ADRA2A gene with ADHD was found using the transmission disequilibrium test in this set of families Non-significant
Cho SC, 2008(b) C allele of ADRA2A DraI polymorphism showed preferential transmission; haplotype C/C P-value=0.051, X2=3.80; a trend of over-transmission of haplotype C/C was observed Significant
Deupree JD, 2006 HhaI-DraI haplotype 1 1 (GC), TDT P-value=0.035, sigma2 (1df) =4.45; MspI-HhaI-DraI haplotype 1 1 1 or CGC, TDT P-value=0.046, sigma2 (1df) =4.00; ADRA2A may play a role in ADHD Significant
Park L, 2005 haplotype 212 (rarer alleles of the DraI and MspI RFLPs, and the common allele of the HhaI RFLP) TDT P-value=0.013, X2=6.23, RR=5.50 in ADHD-C; TDT P-value=0.011, X2=6.55, RR=3.40 in ADHD-(C+PI); supported the hypothesis that an allele of the ADRA2A gene is associated and linked with the ADHD combined subtype Significant
Schmitz M, 2006 CC+CG genotypes, P-value=0.02, OR=3.78, ADRA2A may be associated with ADHD inattentive type Significant

Gene related SNPs (count: 6)

Literature-origin SNPs (count: 5)

LD-proxies (count: 1)


Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 63)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 63)


Gene related KEGG pathways (count: 1)

Genes shared at least 5 GO terms with ADRA2A (count: 91)

Genes shared at least 2 KEGG pathways with ADRA2A (count: 0)

View in gBrowse

Region: chr10:112836790..112840658 View in gBrowse
View in gBrowse