ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CACNA1A
Previous Symbol	CACNL1A4, SCA6, MHP1, MHP
Symbol Alias	Cav2.1, EA2, APCA, HPCA, FHM
Approved Name	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Location	19p13
Position	chr19:13317256-13734804, -1
External Links	HGNC: 1388 Entrez Gene: 773 Ensembl: ENSG00000141837 UCSC: uc010xne.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0050796	regulation of insulin secretion	biological process	TAS	25
GO:0005886	plasma membrane	cellular component	IDA[16595610]; TAS	839
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0007204	elevation of cytosolic calcium ion concentration	biological process	ISS	21
GO:0042995	cell projection	cellular component	IDA[16595610]	12
GO:0008219	cell death	biological process	IDA[16595610]	33
GO:0005515	protein binding	molecular function	IPI	1015
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0005634	nucleus	cellular component	IDA[16595610]	877
GO:0006112	energy reserve metabolic process	biological process	TAS	31
GO:0005891	voltage-gated calcium channel complex	cellular component	IEA	19
GO:0007268	synaptic transmission	biological process	TAS	103
GO:0019905	syntaxin binding	molecular function	IDA[8692999]	6
GO:0016021	integral to membrane	cellular component	TAS[16595610]	932
GO:0005245	voltage-gated calcium channel activity	molecular function	IDA[12451115]; ISS	22
GO:0005737	cytoplasm	cellular component	IDA[16595610]	781
GO:0051899	membrane depolarization	biological process	TAS	9

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa04010	MAPK signaling pathway	68
hsa04730	Long-term depression	27
hsa04742	Taste transduction	10
hsa04930	Type II diabetes mellitus	13
hsa04020	Calcium signaling pathway	66

Genes shared at least 5 GO terms with CACNA1A (count: 35)

Gene Symbol	Pathway Count	Pathway List
CACNA1C	12	regulation of insulin secretion; plasma membrane; small molecule metabolic process; elevation of cytosolic calcium ion concentration; protein binding; metal ion binding; energy reserve metabolic process; voltage-gated calcium channel complex; synaptic transmission; integral to membrane; voltage-gated calcium channel activity; cytoplasm;
CACNA1E	9	regulation of insulin secretion; plasma membrane; small molecule metabolic process; metal ion binding; energy reserve metabolic process; voltage-gated calcium channel complex; synaptic transmission; voltage-gated calcium channel activity; membrane depolarization;
ADCY4	8	plasma membrane; small molecule metabolic process; protein binding; metal ion binding; energy reserve metabolic process; synaptic transmission; integral to membrane; cytoplasm;
SNAP25	7	regulation of insulin secretion; plasma membrane; small molecule metabolic process; protein binding; energy reserve metabolic process; synaptic transmission; cytoplasm;
STX1A	7	regulation of insulin secretion; plasma membrane; small molecule metabolic process; protein binding; energy reserve metabolic process; synaptic transmission; integral to membrane;
CACNA1D	7	regulation of insulin secretion; plasma membrane; small molecule metabolic process; metal ion binding; energy reserve metabolic process; voltage-gated calcium channel complex; voltage-gated calcium channel activity;
ADCY2	7	plasma membrane; small molecule metabolic process; metal ion binding; energy reserve metabolic process; synaptic transmission; integral to membrane; cytoplasm;
CACNA1B	7	plasma membrane; protein binding; metal ion binding; voltage-gated calcium channel complex; synaptic transmission; voltage-gated calcium channel activity; membrane depolarization;
ADRA2A	6	regulation of insulin secretion; plasma membrane; small molecule metabolic process; protein binding; energy reserve metabolic process; cytoplasm;
VAMP2	6	regulation of insulin secretion; plasma membrane; small molecule metabolic process; protein binding; energy reserve metabolic process; synaptic transmission;
ADRA2C	6	regulation of insulin secretion; plasma membrane; small molecule metabolic process; protein binding; energy reserve metabolic process; cytoplasm;
CACNB4	6	plasma membrane; protein binding; voltage-gated calcium channel complex; synaptic transmission; voltage-gated calcium channel activity; membrane depolarization;
SLC6A3	6	plasma membrane; cell death; protein binding; synaptic transmission; integral to membrane; cytoplasm;
PRKD1	6	plasma membrane; small molecule metabolic process; protein binding; metal ion binding; nucleus; cytoplasm;
ADCY3	6	plasma membrane; small molecule metabolic process; metal ion binding; energy reserve metabolic process; synaptic transmission; cytoplasm;
CACNG2	6	plasma membrane; protein binding; voltage-gated calcium channel complex; synaptic transmission; voltage-gated calcium channel activity; membrane depolarization;
ITPR2	5	regulation of insulin secretion; plasma membrane; small molecule metabolic process; energy reserve metabolic process; integral to membrane;
ITPR1	5	regulation of insulin secretion; small molecule metabolic process; protein binding; energy reserve metabolic process; integral to membrane;
PRKAR2B	5	regulation of insulin secretion; plasma membrane; small molecule metabolic process; energy reserve metabolic process; cytoplasm;
AXIN1	5	plasma membrane; cell death; protein binding; nucleus; cytoplasm;
PDE2A	5	plasma membrane; protein binding; metal ion binding; nucleus; cytoplasm;
ENPP1	5	plasma membrane; small molecule metabolic process; protein binding; metal ion binding; integral to membrane;
ACHE	5	plasma membrane; small molecule metabolic process; protein binding; nucleus; synaptic transmission;
CACNA1S	5	plasma membrane; metal ion binding; voltage-gated calcium channel complex; voltage-gated calcium channel activity; cytoplasm;
PICK1	5	plasma membrane; protein binding; metal ion binding; synaptic transmission; cytoplasm;
ADCY9	5	plasma membrane; small molecule metabolic process; metal ion binding; energy reserve metabolic process; synaptic transmission;
CACNG4	5	plasma membrane; voltage-gated calcium channel complex; synaptic transmission; voltage-gated calcium channel activity; membrane depolarization;
PPP4C	5	plasma membrane; protein binding; metal ion binding; nucleus; cytoplasm;
STXBP3	5	plasma membrane; protein binding; nucleus; syntaxin binding; cytoplasm;
CRYAB	5	plasma membrane; protein binding; metal ion binding; nucleus; cytoplasm;
PIK3CG	5	plasma membrane; small molecule metabolic process; elevation of cytosolic calcium ion concentration; protein binding; cytoplasm;
MC4R	5	plasma membrane; protein binding; nucleus; energy reserve metabolic process; integral to membrane;
LPXN	5	plasma membrane; cell projection; protein binding; nucleus; cytoplasm;
PPP1CA	5	small molecule metabolic process; protein binding; metal ion binding; nucleus; cytoplasm;
STK11	5	small molecule metabolic process; protein binding; nucleus; energy reserve metabolic process; cytoplasm;

Genes shared at least 2 KEGG pathways with CACNA1A (count: 32)

Gene Symbol	Pathway Count	Pathway List
CACNA1B	4	MAPK signaling pathway; Taste transduction; Type II diabetes mellitus; Calcium signaling pathway;
CACNA1D	3	MAPK signaling pathway; Type II diabetes mellitus; Calcium signaling pathway;
MAPK1	3	MAPK signaling pathway; Long-term depression; Type II diabetes mellitus;
CACNA1E	3	MAPK signaling pathway; Type II diabetes mellitus; Calcium signaling pathway;
CACNA1C	3	MAPK signaling pathway; Type II diabetes mellitus; Calcium signaling pathway;
MAPK3	3	MAPK signaling pathway; Long-term depression; Type II diabetes mellitus;
CACNA1G	3	MAPK signaling pathway; Type II diabetes mellitus; Calcium signaling pathway;
PLCB2	3	Long-term depression; Taste transduction; Calcium signaling pathway;
CACNA1I	2	MAPK signaling pathway; Calcium signaling pathway;
PLA2G2D	2	MAPK signaling pathway; Long-term depression;
PLA2G4B	2	MAPK signaling pathway; Long-term depression;
PLA2G3	2	MAPK signaling pathway; Long-term depression;
CACNA1H	2	MAPK signaling pathway; Calcium signaling pathway;
PLA2G6	2	MAPK signaling pathway; Long-term depression;
PLA2G5	2	MAPK signaling pathway; Long-term depression;
PLA2G1B	2	MAPK signaling pathway; Long-term depression;
CACNA1F	2	MAPK signaling pathway; Calcium signaling pathway;
CACNA1S	2	MAPK signaling pathway; Calcium signaling pathway;
PPP3R2	2	MAPK signaling pathway; Calcium signaling pathway;
PLA2G2A	2	MAPK signaling pathway; Long-term depression;
MAPK9	2	MAPK signaling pathway; Type II diabetes mellitus;
PLA2G10	2	MAPK signaling pathway; Long-term depression;
PLA2G2E	2	MAPK signaling pathway; Long-term depression;
PLCB3	2	Long-term depression; Calcium signaling pathway;
ITPR2	2	Long-term depression; Calcium signaling pathway;
GRM1	2	Long-term depression; Calcium signaling pathway;
GRM5	2	Long-term depression; Calcium signaling pathway;
RYR1	2	Long-term depression; Calcium signaling pathway;
NOS1	2	Long-term depression; Calcium signaling pathway;
ITPR1	2	Long-term depression; Calcium signaling pathway;
ADCY3	2	Taste transduction; Calcium signaling pathway;
ADCY4	2	Taste transduction; Calcium signaling pathway;

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Region: chr19:13317256..13734804 View in gBrowse