ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007268
Name synaptic transmission
Type biological process
No. of Genes in ADHDgene  103
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 103)

Literature-origin genes (count: 45)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
SNAP25 synaptosomal-associated protein, 25kDa 20p12-p11.2 21(16/5/0) NAS[8760387]; TAS
MAOA monoamine oxidase A Xp11.4-p11.3 20(13/7/0) TAS
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 3p12 1(0/1/0) TAS[8380639]
COMT catechol-O-methyltransferase 22q11.21 29(7/22/0) TAS
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 13(7/6/0) TAS[9109547]
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 15q24 1(0/1/0) TAS
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3p25.3 1(0/1/0) TAS
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 6q14-q15 2(2/0/0) TAS[1608964]
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 3(0/3/0) IEA
STX1A syntaxin 1A (brain) 7q11.2 3(2/1/0) TAS
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 10p12 1(1/0/0) IEA
GRM1 glutamate receptor, metabotropic 1 6q24 1(1/0/0) TAS[9076744]
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 1(1/0/0) TAS
MTNR1B melatonin receptor 1B 11q21-q22 1(0/0/1) TAS[7568007]
SYT1 synaptotagmin I 12q21.2 4(2/2/0) TAS
DRD5 dopamine receptor D5 4p16.1 22(14/6/2) NAS[7727453]
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 6q13 14(5/9/0) IEA
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 5p15.3 70(43/26/1) TAS
GRIK4 glutamate receptor, ionotropic, kainate 4 11q23.3 1(0/1/0) TAS
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 11q23.1 3(1/2/0) TAS[9950429]
GRM7 glutamate receptor, metabotropic 7 3p26-p25 3(2/1/0) IDA[9473604]
CPLX1 complexin 1 4p16.3 1(1/0/0) TAS
SLC38A1 solute carrier family 38, member 1 12q13.11 1(0/1/0) TAS
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 17p13.1 2(0/2/0) TAS
KCNC1 potassium voltage-gated channel, Shaw-related subfamily, member 1 11p15 1(0/1/0) TAS
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1p36.3-p34.3 2(1/1/0) TAS[1565658]
GRIK1 glutamate receptor, ionotropic, kainate 1 21q22 1(0/0/1) TAS
FGF12 fibroblast growth factor 12 3q28 1(0/1/0) IEA
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 11q23.1-q23.2 1(0/1/0) TAS[7565620]
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 10q21-q24 1(0/1/0) TAS[8226867]
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 16q12.2 16(10/5/1) TAS[2008212]
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 4p12 1(0/0/1) IEA
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Xq23 5(2/3/0) TAS[9241279]
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 9q34 21(12/9/0) TAS[2880016]
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2q12 1(1/0/0) TAS
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 2(0/1/1) TAS
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 5p13 2(1/1/0) TAS[7521911]
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 10q25 2(0/2/0) TAS
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 20q13.33 7(4/3/0) NAS[7550350]; TAS
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p12 2(1/1/0) TAS
GRM5 glutamate receptor, metabotropic 5 11q14.3 2(1/0/1) IEA
HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1 5p12 1(0/1/0) TAS
SYT2 synaptotagmin II 1q32.1 1(1/0/0) TAS
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1p36-p35 2(0/2/0) TAS[8522988]
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 4(1/3/0) TAS

Genes from other sources Help (count: 58)

Approved Symbol Approved Name Source Evidence[PMID]
NOVA1 neuro-oncological ventral antigen 1 Mapped by significant region TAS[8558240]
KCNK7 potassium channel, subfamily K, member 7 Mapped by significant region TAS
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Mapped by PBA pathway TAS
SCN2B sodium channel, voltage-gated, type II, beta subunit Mapped by significant region TAS[9295116]
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 Mapped by CNV; Mapped by significant region TAS
GNG10 guanine nucleotide binding protein (G protein), gamma 10 Mapped by significant region TAS
KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12 Mapped by significant region TAS
ADCY4 adenylate cyclase 4 Mapped by significant region TAS
KCNIP1 Kv channel interacting protein 1 Mapped by Literature SNP TAS[10676964]
KCNG4 potassium voltage-gated channel, subfamily G, member 4 Mapped by significant region TAS
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 Mapped by PBA pathway TAS
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit Mapped by PBA pathway TAS
GRM6 glutamate receptor, metabotropic 6 Mapped by CNV IEA
PLCB2 phospholipase C, beta 2 Mapped by PBA pathway TAS
DOC2A double C2-like domains, alpha Mapped by CNV TAS[7826360]
OMP olfactory marker protein Mapped by significant region TAS[8790421]
CACNB4 calcium channel, voltage-dependent, beta 4 subunit Mapped by PBA pathway TAS
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) Mapped by LD-proxy TAS
CAMK2D calcium/calmodulin-dependent protein kinase II delta Mapped by CNV TAS
PDPK1 3-phosphoinositide dependent protein kinase-1 Mapped by significant region TAS
KCNN2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 Mapped by LD-proxy TAS
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Mapped by significant region TAS
CACNB3 calcium channel, voltage-dependent, beta 3 subunit Mapped by PBA pathway TAS
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit Mapped by PBA pathway IEA
GLUL glutamate-ammonia ligase Mapped by significant region TAS
KCNF1 potassium voltage-gated channel, subfamily F, member 1 Mapped by significant region TAS
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha Mapped by CNV TAS[8662589]
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 Mapped by CNV; Mapped by significant region IEA
DTNA dystrobrevin, alpha Mapped by significant region TAS[8845841]
ADCY9 adenylate cyclase 9 Mapped by significant region TAS
PANX1 pannexin 1 Mapped by significant region TAS
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 Mapped by CNV; Mapped by significant region NAS; TAS
ACHE acetylcholinesterase (Yt blood group) Mapped by PBA pathway TAS
UNC13C unc-13 homolog C (C. elegans) Mapped by CNV IEA
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) Mapped by LD-proxy TAS
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) Mapped by PBA pathway ISS[10729324]
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 Mapped by PBA pathway TAS
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 Mapped by CNV; Mapped by significant region TAS
PDE7B phosphodiesterase 7B Mapped by significant region TAS[10814504]
KCNK4 potassium channel, subfamily K, member 4 Mapped by significant region TAS
DLG2 discs, large homolog 2 (Drosophila) Mapped by significant region IEA
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy TAS
NPY neuropeptide Y Mapped by CNV; Mapped by significant region TAS[10557353]
GRIA4 glutamate receptor, ionotropic, AMPA 4 Mapped by significant region TAS
HSPA8 heat shock 70kDa protein 8 Mapped by significant region TAS
STX1B syntaxin 1B Mapped by CNV IEA
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 Mapped by significant region TAS
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Mapped by significant region; Mapped by PBA pathway TAS
TAAR5 trace amine associated receptor 5 Mapped by significant region TAS[9464258]
ABAT 4-aminobutyrate aminotransferase Mapped by significant region TAS
RAPSN receptor-associated protein of the synapse Mapped by LD-proxy TAS[8812503]
PICK1 protein interacting with PRKCA 1 Mapped by Literature SNP TAS
RIT2 Ras-like without CAAX 2 Mapped by significant region TAS[8918462]
KCNJ1 potassium inwardly-rectifying channel, subfamily J, member 1 Mapped by significant region TAS
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 Mapped by significant region TAS
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) Mapped by significant region TAS
ADCY3 adenylate cyclase 3 Mapped by LD-proxy TAS
ADCY2 adenylate cyclase 2 (brain) Mapped by significant region TAS