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Gene Report
Basic Info
| Approved Symbol | PRKAR2B |
|---|---|
| Previous Symbol | PRKAR2 |
| Approved Name | protein kinase, cAMP-dependent, regulatory, type II, beta |
| Location | 7q22.3 |
| Position | chr7:106685094-106802256, + |
| External Links |
HGNC: 9392 Entrez Gene: 5577 Ensembl: ENSG00000005249 UCSC: uc003vdx.2 |
| No. of Studies | 0 (significant: 0; non-significant: 0; trend: 0) |
| Source | Mapped by CNV |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 1)
| ID | Location | Size | Band | Type | Inheritance |
|---|---|---|---|---|---|
| CNV_Jarick[2012]_18 | chr7:105951552-106708212 (NCBI36 / hg18) | 756661 | 7q22.3 | dup |
Gene related other variant (count: 0)
Gene related regions (count: 0)
Gene related GO terms (count: 32)
GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)
GO terms by database search (count: 32)
Gene related KEGG pathways (count: 2)
| ID | Name | No. of Genes in ADHDgene | Brief Description |
|---|---|---|---|
| hsa04210 | Apoptosis | 13 | Apoptosis is a genetically controlled mechanisms of cell dea...... Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis. More... |
| hsa04910 | Insulin signaling pathway | 29 | Insulin binding to its receptor results in the tyrosine phos...... Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR. More... |
Genes shared at least 5 GO terms with PRKAR2B (count: 45)
Genes shared at least 2 KEGG pathways with PRKAR2B (count: 3)
| Gene Symbol | Pathway Count | Pathway List |
|---|---|---|
| BAD | 2 | Apoptosis; Insulin signaling pathway; |
| PIK3CG | 2 | Apoptosis; Insulin signaling pathway; |
| PIK3R1 | 2 | Apoptosis; Insulin signaling pathway; |
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Region: chr7:106685094..106802256 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014