ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0035556
Name intracellular signal transduction
Type biological process
No. of Genes in ADHDgene  52
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 52)

Literature-origin genes (count: 10)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
DCDC2 doublecortin domain containing 2 6p22.1 1(1/0/0) IEA
DUSP1 dual specificity phosphatase 1 5q35.1 1(0/1/0) IEA
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 3p24.3 1(0/0/1) IDA[10339589]
DCLK1 doublecortin-like kinase 1 13q13.3 1(1/0/0) IEA
DGKH diacylglycerol kinase, eta 13q13.3 2(1/1/0) IEA
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0) IDA[14749367]
DCLK2 doublecortin-like kinase 2 4q31.3 1(0/0/1) IEA
SH2B1 SH2B adaptor protein 1 16p11.2 1(0/1/0) IEA
PLCL1 phospholipase C-like 1 2q33 1(0/0/1) IEA
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 17q12 1(0/1/0) IEA

Genes from other sources Help (count: 42)

Approved Symbol Approved Name Source Evidence[PMID]
SQSTM1 sequestosome 1 Mapped by CNV TAS[8650207]
SHANK2 SH3 and multiple ankyrin repeat domains 2 Mapped by significant region NAS
ADCY3 adenylate cyclase 3 Mapped by LD-proxy IEA
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like Mapped by CNV NAS[11072084]
UNC13C unc-13 homolog C (C. elegans) Mapped by CNV IEA
ADCY4 adenylate cyclase 4 Mapped by significant region IEA
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 Mapped by CNV; Mapped by significant region NAS
CNIH2 cornichon family AMPA receptor auxiliary protein 2 Mapped by significant region IEA
IGFBP5 insulin-like growth factor binding protein 5 Mapped by significant region IEA
PDPK1 3-phosphoinositide dependent protein kinase-1 Mapped by significant region IDA[14749367]
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 Mapped by significant region IEA
SH2B3 SH2B adaptor protein 3 Mapped by LD-proxy IEA
PLCD1 phospholipase C, delta 1 Mapped by PBA pathway IEA
PLCD4 phospholipase C, delta 4 Mapped by significant region IEA
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 Mapped by significant region NAS
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) Mapped by significant region IEA
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 Mapped by significant region IEA
PDZD8 PDZ domain containing 8 Mapped by LD-proxy IEA
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) Mapped by significant region IEA
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like Mapped by CNV TAS[8361759]
PLCB2 phospholipase C, beta 2 Mapped by PBA pathway IEA
ITK IL2-inducible T-cell kinase Mapped by significant region IEA
ADCY2 adenylate cyclase 2 (brain) Mapped by significant region IEA
SDCBP2 syndecan binding protein (syntenin) 2 Mapped by Literature SNP NAS[11152476]
DEF8 differentially expressed in FDCP 8 homolog (mouse) Mapped by significant region IEA
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta Mapped by CNV TAS[2851102]
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 Mapped by significant region IEA
CTGF connective tissue growth factor Mapped by significant region IEA
ADCY9 adenylate cyclase 9 Mapped by significant region IEA
RGS11 regulator of G-protein signaling 11 Mapped by significant region IEA
AKAP7 A kinase (PRKA) anchor protein 7 Mapped by significant region TAS[10613906]
STAC3 SH3 and cysteine rich domain 3 Mapped by CNV IEA
RASA1 RAS p21 protein activator (GTPase activating protein) 1 Mapped by PBA pathway NAS[1581965]
SIPA1 signal-induced proliferation-associated 1 Mapped by significant region NAS[9346962]
CARHSP1 calcium regulated heat stable protein 1, 24kDa Mapped by significant region TAS[9712905]
STMN1 stathmin 1 Mapped by PBA pathway TAS[2917975]
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) Mapped by PBA pathway NAS[10085124]
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 Mapped by significant region NAS[10747847]
ZP4 zona pellucida glycoprotein 4 Mapped by CNV IMP[18667750]
DGKG diacylglycerol kinase, gamma 90kDa Mapped by Literature SNP IEA
CORO2A coronin, actin binding protein, 2A Mapped by significant region TAS[8985118]
ASB15 ankyrin repeat and SOCS box containing 15 Mapped by CNV IEA