ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DCLK1
Previous Symbol	DCAMKL1
Symbol Alias	KIAA0369, DCLK, DCDC3A
Approved Name	doublecortin-like kinase 1
Previous Name	doublecortin and CaM kinase-like 1
Location	13q13.3
Position	chr13:36343122-36705464, -
External Links	HGNC: 2700 Entrez Gene: 9201 Ensembl: ENSG00000133083 UCSC: uc001uvf.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Havik, B., 2012	Our results suggest that genetic variants in DCLK1 are associated with SCZ and, to a lesser extent, with ADHD and BP. Interestingly the association is strongest when SCZ and ADHD are considered together, suggesting common genetic susceptibility.	Significant

Gene related SNPs (count: 102)

Literature-origin SNPs (count: 13)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs9545297	Chr13:36341668(Fwd)	downstream_gene_variant	1(0/1/0)
rs9545424	Chr13:36383264(Fwd)	intron_variant; upstream_gene_variant	1(0/1/0)
rs1539549	Chr13:36451881(Fwd)	intron_variant	2(0/2/0)
rs10492555	Chr13:36709109(Fwd)	upstream_gene_variant	1(0/1/0)
rs10507435	Chr13:36440996(Fwd)	intron_variant	1(1/0/0)
rs7989807	Chr13:36625089(Fwd)	intron_variant	1(1/0/0)
rs7990263	Chr13:36461216(Fwd)	intron_variant	1(0/1/0)
rs7999483	Chr13:36353437(Fwd)	intron_variant	1(0/1/0)
rs1750921	Chr13:36452069(Fwd)	intron_variant	1(0/1/0)
rs1926452	Chr13:36444937(Fwd)	intron_variant	1(0/1/0)
rs12874830	Chr13:36572040(Fwd)	intron_variant	1(1/0/0)
rs2051090	Chr13:36454193(Fwd)	intron_variant	1(0/1/0)
rs7327771	Chr13:36679512(Fwd)	intron_variant	1(0/1/0)

LD-proxies (count: 89)

rs_ID	Location	Functional Annotation
rs11147591	Chr13:36450397(Fwd)	intron_variant
rs4943346	Chr13:36450937(Fwd)	intron_variant
rs10507434	Chr13:36440404(Fwd)	intron_variant
rs4943345	Chr13:36447910(Fwd)	intron_variant
rs4943348	Chr13:36451010(Fwd)	intron_variant
rs17786591	Chr13:36444633(Fwd)	intron_variant
rs12427442	Chr13:36437182(Fwd)	intron_variant
rs11838747	Chr13:36443674(Fwd)	intron_variant
rs17786544	Chr13:36444147(Fwd)	intron_variant
rs4997646	Chr13:36438985(Fwd)	intron_variant
rs943220	Chr13:36439252(Fwd)	intron_variant
rs12427459	Chr13:36437371(Fwd)	intron_variant
rs17181655	Chr13:36438130(Fwd)	intron_variant
rs17786285	Chr13:36438384(Fwd)	intron_variant
rs9601513	Chr13:36441438(Fwd)	intron_variant
rs7986427	Chr13:36443324(Fwd)	intron_variant
rs12428086	Chr13:36441099(Fwd)	intron_variant
rs9531436	Chr13:36674859(Fwd)	intron_variant
rs7329944	Chr13:36679372(Fwd)	intron_variant
rs7994985	Chr13:36675449(Fwd)	intron_variant
rs1343190	Chr13:36524208(Fwd)	intron_variant
rs9545328	Chr13:36352139(Fwd)	intron_variant
rs1171057	Chr13:36497808(Fwd)	intron_variant
rs9574568	Chr13:36351355(Fwd)	intron_variant
rs1418985	Chr13:36495803(Fwd)	intron_variant
rs1886549	Chr13:36339275(Fwd)
rs9531216	Chr13:36495741(Fwd)	intron_variant
rs872060	Chr13:36338917(Fwd)
rs9565540	Chr13:36338503(Fwd)
rs9574530	Chr13:36338459(Fwd)
rs9574529	Chr13:36338432(Fwd)
rs9574528	Chr13:36338195(Fwd)
rs17052887	Chr13:36380989(Fwd)	intron_variant; nc_transcript_variant
rs9645963	Chr13:36349503(Fwd)	intron_variant
rs9545332	Chr13:36355680(Fwd)	intron_variant
rs7992754	Chr13:36352224(Fwd)	intron_variant
rs9545294	Chr13:36340767(Fwd)	downstream_gene_variant
rs2066448	Chr13:36547142(Fwd)	intron_variant
rs1361824	Chr13:36559951(Fwd)	intron_variant
rs1171052	Chr13:36499098(Fwd)	intron_variant
rs1171072	Chr13:36502031(Fwd)	intron_variant
rs9575015	Chr13:36542754(Fwd)	intron_variant
rs3803279	Chr13:36345019(Fwd)	downstream_gene_variant
rs1170985	Chr13:36542954(Fwd)	intron_variant
rs1022945	Chr13:36545120(Fwd)	intron_variant
rs9565720	Chr13:36546563(Fwd)	intron_variant
rs9565715	Chr13:36535494(Fwd)	intron_variant
rs9575010	Chr13:36537653(Fwd)	intron_variant
rs9601789	Chr13:36539910(Fwd)	intron_variant
rs1170984	Chr13:36542240(Fwd)	intron_variant
rs9574527	Chr13:36338151(Fwd)
rs9575003	Chr13:36534075(Fwd)	intron_variant
rs1305870	Chr13:36597840(Fwd)	intron_variant
rs9565707	Chr13:36534491(Fwd)	intron_variant
rs41464045	Chr13:36631355(Fwd)	intron_variant
rs9565709	Chr13:36534745(Fwd)	intron_variant
rs9565713	Chr13:36535217(Fwd)	intron_variant
rs7988209	Chr13:36672942(Fwd)	intron_variant
rs7332579	Chr13:36500741(Fwd)	intron_variant
rs9574930	Chr13:36499846(Fwd)	intron_variant
rs9574926	Chr13:36498356(Fwd)	intron_variant
rs9574969	Chr13:36525307(Fwd)	intron_variant
rs7989245	Chr13:36499597(Fwd)	intron_variant
rs11843701	Chr13:36341438(Fwd)	downstream_gene_variant
rs9574928	Chr13:36498999(Fwd)	intron_variant
rs1171093	Chr13:36509456(Fwd)	intron_variant
rs1171075	Chr13:36506542(Fwd)	intron_variant
rs1171090	Chr13:36510728(Fwd)	intron_variant
rs1171092	Chr13:36509728(Fwd)	intron_variant
rs11843245	Chr13:36340137(Fwd)
rs1045696	Chr13:36345816(Fwd)	3_prime_UTR_variant
rs9646082	Chr13:36362830(Fwd)	intron_variant; nc_transcript_variant
rs7326177	Chr13:36363908(Fwd)	intron_variant; nc_transcript_variant
rs9545421	Chr13:36381662(Fwd)	intron_variant; nc_transcript_variant
rs9545423	Chr13:36381778(Fwd)	intron_variant; nc_transcript_variant
rs11840264	Chr13:36352245(Fwd)	intron_variant
rs6563164	Chr13:36370428(Fwd)	intron_variant; upstream_gene_variant
rs9545395	Chr13:36370970(Fwd)	intron_variant; upstream_gene_variant
rs12855118	Chr13:36372410(Fwd)	intron_variant; upstream_gene_variant
rs17052884	Chr13:36380806(Fwd)	intron_variant; nc_transcript_variant
rs9565848	Chr13:36676259(Fwd)	intron_variant
rs17053405	Chr13:36642259(Fwd)	intron_variant
rs8000568	Chr13:36681361(Fwd)	intron_variant
rs9545602	Chr13:36456503(Fwd)	intron_variant
rs1936002	Chr13:36456084(Fwd)	intron_variant
rs4941823	Chr13:36453926(Fwd)	intron_variant
rs9545604	Chr13:36456942(Fwd)	intron_variant
rs4943350	Chr13:36453860(Fwd)	intron_variant
rs4941822	Chr13:36453613(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048813	dendrite morphogenesis	Biological Process		8
GO:0007417	central nervous system development	Biological Process	TAS[10051403]	22
GO:0007399	nervous system development	Biological Process	TAS[10036192]	54
GO:0016197	endosomal transport	Biological Process	NAS[14613930]	11
GO:0009615	response to virus	Biological Process	IEP[16548883]	21
GO:0030900	forebrain development	Biological Process		9
GO:0021952	central nervous system projection neuron axonogenesis	Biological Process		2
GO:0048675	axon extension	Biological Process		3
GO:0035556	intracellular signal transduction	Biological Process		44
GO:0004672	protein kinase activity	Molecular Function	TAS[9747029]	27
GO:0004674	protein serine/threonine kinase activity	Molecular Function		61
GO:0001764	neuron migration	Biological Process		21
GO:0005887	integral to plasma membrane	Cellular Component	TAS[10036192]	220
GO:0006468	protein phosphorylation	Biological Process	TAS[9747029]	53
GO:0005057	receptor signaling protein activity	Molecular Function	TAS[10036192]	9
GO:0005524	ATP binding	Molecular Function		228

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DCLK1 (count: 0)

Genes shared at least 2 KEGG pathways with DCLK1 (count: 0)

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Region: chr13:36343122..36705464 View in gBrowse