ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007399
Name nervous system development
Type biological process
No. of Genes in ADHDgene  60
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 60)

Literature-origin genes (count: 17)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
ZNF423 zinc finger protein 423 16q12 1(0/0/1) IEA
GDNF glial cell derived neurotrophic factor 5p13.1-p12 2(1/1/0) TAS[8637574]
CNTFR ciliary neurotrophic factor receptor 9p13 1(1/0/0) TAS[7585948]
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 15q24 1(0/1/0) IMP[11450844]
DCLK1 doublecortin-like kinase 1 13q13.3 1(1/0/0) TAS[10036192]
MOBP myelin-associated oligodendrocyte basic protein 3p21.33 1(0/0/1) IEA
FGF12 fibroblast growth factor 12 3q28 1(0/1/0) TAS[8790420]
HES6 hes family bHLH transcription factor 6 2q37.3 1(0/1/0) IEA
CNTN4 contactin 4 3p26.3 1(1/0/0) IMP[15106122]
NRSN1 neurensin 1 6p22.1 1(1/0/0) ISS
BDNF brain-derived neurotrophic factor 11p14.1 16(8/8/0) TAS[2236018]
GRIK1 glutamate receptor, ionotropic, kainate 1 21q22 1(0/0/1) TAS[8260617]
CPLX2 complexin 2 5q35.2 2(1/0/1) IEA
NTF3 neurotrophin 3 12p13 4(1/3/0) TAS[1542658]
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0) TAS[15351965]
MYT1L myelin transcription factor 1-like 2p25.3 1(0/0/1) IEA
HES1 hes family bHLH transcription factor 1 3q28-q29 1(1/0/0) TAS[8020957]

Genes from other sources Help (count: 43)

Approved Symbol Approved Name Source Evidence[PMID]
SCN2B sodium channel, voltage-gated, type II, beta subunit Mapped by significant region IEA
AQP4 aquaporin 4 Mapped by significant region TAS[7528931]
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 Mapped by significant region NAS[10486569]
NDN necdin, melanoma antigen (MAGE) family member Mapped by CNV; Mapped by significant region TAS[9630521]
FGF19 fibroblast growth factor 19 Mapped by significant region TAS[9931477]
MAP1S microtubule-associated protein 1S Mapped by PBA pathway ISS[16297881]
INHA inhibin, alpha Mapped by significant region NAS[10320815]
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 Mapped by significant region IEA
NBL1 neuroblastoma 1, DAN family BMP antagonist Mapped by LD-proxy ISS
NINJ1 ninjurin 1 Mapped by significant region TAS[9261151]
TPP1 tripeptidyl peptidase I Mapped by CNV IMP[9295267]
CHRM1 cholinergic receptor, muscarinic 1 Mapped by significant region; Mapped by PBA pathway TAS[2739737]
SDCBP2 syndecan binding protein (syntenin) 2 Mapped by Literature SNP NAS[11152476]
NEUROD2 neuronal differentiation 2 Mapped by LD-proxy TAS[8816493]
DGCR14 DiGeorge syndrome critical region gene 14 Mapped by CNV ISS[8703114]
DOC2A double C2-like domains, alpha Mapped by CNV TAS[7826360]
FABP7 fatty acid binding protein 7, brain Mapped by significant region TAS[9375786]
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) Mapped by significant region TAS[9635427]
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A Mapped by significant region TAS[9464278]
ACHE acetylcholinesterase (Yt blood group) Mapped by PBA pathway TAS[11283752]
GLIS2 GLIS family zinc finger 2 Mapped by significant region IEA
FKTN fukutin Mapped by significant region TAS[9690476]
CTF1 cardiotrophin 1 Mapped by CNV TAS[7738033]
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) Mapped by significant region TAS[9096408]
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) Mapped by significant region IMP[16361598]
TRPC5 transient receptor potential cation channel, subfamily C, member 5 Mapped by PBA pathway TAS[10493832]
AHNAK AHNAK nucleoprotein Mapped by significant region NAS
NRGN neurogranin (protein kinase C substrate, RC3) Mapped by significant region TAS[10075657]
LHX1 LIM homeobox 1 Mapped by CNV TAS[9212161]
CHRM3 cholinergic receptor, muscarinic 3 Mapped by CNV; Mapped by PBA pathway TAS[2739737]
TRIM3 tripartite motif containing 3 Mapped by CNV TAS[10391919]
CABLES1 Cdk5 and Abl enzyme substrate 1 Mapped by significant region IEA
MARK4 MAP/microtubule affinity-regulating kinase 4 Mapped by PBA pathway IDA[14594945]
GAL galanin/GMAP prepropeptide Mapped by CNV; Mapped by significant region IEA
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal Mapped by CNV; Mapped by PBA pathway TAS[7670466]
NLGN1 neuroligin 1 Mapped by CNV ISS
NELL1 NEL-like 1 (chicken) Mapped by CNV TAS[8975702]
SIGMAR1 sigma non-opioid intracellular receptor 1 Mapped by LD-proxy IEA
ERBB2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 Mapped by LD-proxy TAS[15504738]
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Mapped by CNV IEA
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 Mapped by CNV; Mapped by significant region TAS[9890987]
DPYSL4 dihydropyrimidinase-like 4 Mapped by CNV TAS[9652388]
ZEB2 zinc finger E-box binding homeobox 2 Mapped by PBA pathway NAS[11279515]