ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CNTN4
Symbol Alias	BIG-2
Approved Name	contactin 4
Location	3p26.3
Position	chr3:2140497-3099645, +
External Links	HGNC: 2174 Entrez Gene: 152330 Ensembl: ENSG00000144619 UCSC: uc003bpc.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by CNV

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Elia, J., 2012	This gene was found directly affected by CNVRs overrepresented in individuals with ADHD.	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_15	chr3:2969491-4461303 (NCBI Build 36.1 (hg18))	1538470	3p26.3-3p26.2	Loss
CNV_Elia[2012]_10	chr3:1844168-1859889 (NCBI36 / hg18)	15722	3p26.3	Del	2:4:0(100%)
CNV_Williams[2010]_10	chr3:1166638-2183832 (NCBI Build 36.1 (hg18))	1017195	3p26.3	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048167	regulation of synaptic plasticity	Biological Process	TAS[15106122]	9
GO:0045665	negative regulation of neuron differentiation	Biological Process	IMP[14571131]	13
GO:0030424	axon	Cellular Component	NAS[14571131]	35
GO:0007420	brain development	Biological Process		33
GO:0031225	anchored to membrane	Cellular Component		29
GO:0031175	neuron projection development	Biological Process		10
GO:0007409	axonogenesis	Biological Process	TAS[14571131]	14
GO:0007399	nervous system development	Biological Process	IMP[15106122]	54
GO:0007413	axonal fasciculation	Biological Process	TAS[15106122]	3
GO:0007411	axon guidance	Biological Process	TAS[15106122]	65
GO:0005576	extracellular region	Cellular Component		240
GO:0007158	neuron cell-cell adhesion	Biological Process	TAS[14571131]	5
GO:0005886	plasma membrane	Cellular Component	NAS[15106122]	772

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CNTN4 (count: 2)

Gene Symbol	Pathway Count	Pathway List
ACHE	5	axon; anchored to membrane; nervous system development; extracellular region; plasma membrane;
NCAM1	5	axon; anchored to membrane; axon guidance; extracellular region; plasma membrane;

Genes shared at least 2 KEGG pathways with CNTN4 (count: 0)

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Region: chr3:2140497..3099645 View in gBrowse