ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0005576
Name	extracellular region
Type	cellular component
No. of Genes in ADHDgene	267
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 267)

Literature-origin genes (count: 22)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	TAS
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	9q34	21(12/9/0)	NAS[14718574]
LPL	lipoprotein lipase	8p22	1(0/0/1)	TAS
CNTN4	contactin 4	3p26.3	1(1/0/0)	IEA
EREG	epiregulin	4q21.21	1(0/0/1)	TAS
NXPH1	neurexophilin 1	7p22	1(0/1/0)	IEA
GPX6	glutathione peroxidase 6 (olfactory)	6p22.1	1(0/1/0)	IEA
BDNF	brain-derived neurotrophic factor	11p14.1	16(8/8/0)	IEA
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11q21-q22	1(0/0/1)	TAS
FGF10	fibroblast growth factor 10	5p13-p12	1(0/1/0)	TAS
TLL2	tolloid-like 2	10q23-q24	1(0/0/1)	IEA
GDNF	glial cell derived neurotrophic factor	5p13.1-p12	2(1/1/0)	IDA[9811930]
NGF	nerve growth factor (beta polypeptide)	1p13.1	2(2/0/0)	TAS
BCHE	butyrylcholinesterase	3q26.1-q26.2	1(1/0/0)	NAS[14718574]; TAS
LECT1	leukocyte cell derived chemotaxin 1	13q14.3	1(0/1/0)	IEA
GFOD1	glucose-fructose oxidoreductase domain containing 1	6p24.1-p23	1(1/0/0)	IEA
NCAN	neurocan	19p12	1(0/1/0)	TAS
NPPC	natriuretic peptide C	2q37.1	1(0/1/0)	NAS
ITIH3	inter-alpha-trypsin inhibitor heavy chain 3	3p21.1	1(1/0/0)	NAS[14718574]
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	4q21.3-q22	1(0/1/0)	TAS
NTF3	neurotrophin 3	12p13	4(1/3/0)	IEA
STX1A	syntaxin 1A (brain)	7q11.2	3(2/1/0)	IEA

Genes from other sources (count: 245)

Approved Symbol	Approved Name	Source	Evidence[PMID]
PGA4	pepsinogen 4, group I (pepsinogen A)	Mapped by significant region	IEA
PLA2G4B	phospholipase A2, group IVB (cytosolic)	Mapped by PBA pathway	TAS[10085124]
C6orf58	chromosome 6 open reading frame 58	Mapped by significant region	IEA
GPX5	glutathione peroxidase 5 (epididymal androgen-related protein)	Mapped by LD-proxy	IEA
IHH	indian hedgehog	Mapped by significant region	NAS
MR1	major histocompatibility complex, class I-related	Mapped by significant region	IEA
IL18	interleukin 18 (interferon-gamma-inducing factor)	Mapped by significant region	TAS
ALDOA	aldolase A, fructose-bisphosphate	Mapped by CNV	TAS
PRSS8	protease, serine, 8	Mapped by CNV	TAS[10077646]
PLA1A	phospholipase A1 member A	Mapped by PBA pathway	IEA
DEFB135	defensin, beta 135	Mapped by CNV	IEA
SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A	Mapped by significant region	NAS
RSPO3	R-spondin 3	Mapped by significant region	IEA
APOL3	apolipoprotein L, 3	Mapped by CNV	IEA
NPVF	neuropeptide VF precursor	Mapped by CNV; Mapped by significant region	IEA
CCL19	chemokine (C-C motif) ligand 19	Mapped by LD-proxy	TAS
TMEM25	transmembrane protein 25	Mapped by significant region	IEA
C11orf44	chromosome 11 open reading frame 44	Mapped by significant region	IEA
PYCARD	PYD and CARD domain containing	Mapped by CNV	IEA
VASN	vasorin	Mapped by significant region	IEA
PATE1	prostate and testis expressed 1	Mapped by significant region	IEA
PTX4	pentraxin 4, long	Mapped by significant region	IEA
C11orf83	chromosome 11 open reading frame 83	Mapped by significant region	IEA
CST6	cystatin E/M	Mapped by significant region	IEA
PLA2G10	phospholipase A2, group X	Mapped by significant region; Mapped by PBA pathway	TAS
ITIH4	inter-alpha-trypsin inhibitor heavy chain family, member 4	Mapped by LD-proxy	NAS[14718574]
TPSAB1	tryptase alpha/beta 1	Mapped by significant region	TAS
FGF4	fibroblast growth factor 4	Mapped by significant region	TAS
CLEC3A	C-type lectin domain family 3, member A	Mapped by significant region	IEA
NPY	neuropeptide Y	Mapped by CNV; Mapped by significant region	TAS
IL6	interleukin 6 (interferon, beta 2)	Mapped by significant region	TAS
ARSJ	arylsulfatase family, member J	Mapped by CNV	IEA
CHRDL2	chordin-like 2	Mapped by significant region	IEA
PDGFD	platelet derived growth factor D	Mapped by significant region	TAS
SAAL1	serum amyloid A-like 1	Mapped by LD-proxy	IEA
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	Mapped by PBA pathway	TAS
GLB1L2	galactosidase, beta 1-like 2	Mapped by CNV; Mapped by significant region	IEA
REG1B	regenerating islet-derived 1 beta	Mapped by CNV	IEA
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	Mapped by CNV	IEA
PLA2G1B	phospholipase A2, group IB (pancreas)	Mapped by PBA pathway	TAS
ENDOD1	endonuclease domain containing 1	Mapped by significant region	IEA
IGF2	insulin-like growth factor 2 (somatomedin A)	Mapped by LD-proxy	TAS
C9	complement component 9	Mapped by significant region	TAS
WNT6	wingless-type MMTV integration site family, member 6	Mapped by significant region	NAS
APOA1	apolipoprotein A-I	Mapped by significant region	TAS
TBC1D15	TBC1 domain family, member 15	Mapped by LD-proxy	IEA
GPHA2	glycoprotein hormone alpha 2	Mapped by significant region	IDA[12089349]
C6	complement component 6	Mapped by significant region	TAS
IGFALS	insulin-like growth factor binding protein, acid labile subunit	Mapped by significant region	NAS[14718574]; TAS
TSKU	tsukushi, small leucine rich proteoglycan	Mapped by significant region	IEA
EDEM2	ER degradation enhancer, mannosidase alpha-like 2	Mapped by Literature SNP	IEA
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	Mapped by Literature SNP; Mapped by CNV	TAS
CRB2	crumbs family member 2	Mapped by significant region	IEA
ZG16B	zymogen granule protein 16B	Mapped by significant region	IEA
OLFML2A	olfactomedin-like 2A	Mapped by significant region	IEA
LGI2	leucine-rich repeat LGI family, member 2	Mapped by CNV	IEA
PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	Mapped by significant region	IEA
KRTAP5-8	keratin associated protein 5-8	Mapped by significant region	NAS
TXN	thioredoxin	Mapped by significant region	IEA
NXPE1	neurexophilin and PC-esterase domain family, member 1	Mapped by significant region	IEA
TMPRSS11D	transmembrane protease, serine 11D	Mapped by significant region	IEA
CABP4	calcium binding protein 4	Mapped by significant region	NAS[16960802]
SEPP1	selenoprotein P, plasma, 1	Mapped by CNV; Mapped by significant region	NAS[14718574]
SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	Mapped by significant region	NAS[14718574]; TAS
CCDC126	coiled-coil domain containing 126	Mapped by CNV; Mapped by significant region	IEA
FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	Mapped by CNV	IEA
DNASE1L2	deoxyribonuclease I-like 2	Mapped by significant region	IEA
TPSD1	tryptase delta 1	Mapped by significant region	IEA
DSC3	desmocollin 3	Mapped by significant region	IEA
PATE3	prostate and testis expressed 3	Mapped by significant region	IEA
ST3GAL4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Mapped by significant region	IEA
DNASE1	deoxyribonuclease I	Mapped by significant region	IEA
HPX	hemopexin	Mapped by CNV	NAS[14718574]
NBL1	neuroblastoma 1, DAN family BMP antagonist	Mapped by LD-proxy	IEA
GNPTG	N-acetylglucosamine-1-phosphate transferase, gamma subunit	Mapped by significant region	IEA
REG3G	regenerating islet-derived 3 gamma	Mapped by CNV	IEA
PRSS27	protease, serine 27	Mapped by significant region	IEA
XYLT1	xylosyltransferase I	Mapped by CNV; Mapped by significant region	IEA
CCL27	chemokine (C-C motif) ligand 27	Mapped by LD-proxy	TAS
CTGF	connective tissue growth factor	Mapped by significant region	TAS
NXPH4	neurexophilin 4	Mapped by CNV	IEA
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	Mapped by CNV	NAS[14718574]
CLCF1	cardiotrophin-like cytokine factor 1	Mapped by significant region	IDA[10966616]; NAS[10448081]
GFER	growth factor, augmenter of liver regeneration	Mapped by significant region	IEA
ENPP3	ectonucleotide pyrophosphatase/phosphodiesterase 3	Mapped by significant region	IEA
TMPRSS11B	transmembrane protease, serine 11B	Mapped by significant region	IEA
VWA3A	von Willebrand factor A domain containing 3A	Mapped by CNV; Mapped by significant region	IEA
FGF3	fibroblast growth factor 3	Mapped by significant region	TAS
CRISPLD2	cysteine-rich secretory protein LCCL domain containing 2	Mapped by CNV; Mapped by significant region	IEA
RESP18	regulated endocrine-specific protein 18	Mapped by significant region	IEA
IGHV4OR15-8	immunoglobulin heavy variable 4/OR15-8 (non-functional)	Mapped by significant region	IEA
F2RL2	coagulation factor II (thrombin) receptor-like 2	Mapped by PBA pathway	TAS
CTRB1	chymotrypsinogen B1	Mapped by significant region	NAS; TAS
VWCE	von Willebrand factor C and EGF domains	Mapped by significant region	IEA
FOLR4	folate receptor 4, delta (putative)	Mapped by significant region	IEA
PON2	paraoxonase 2	Mapped by PBA pathway	IEA
DEFB136	defensin, beta 136	Mapped by CNV	IEA
PRSS22	protease, serine, 22	Mapped by significant region	IEA
TLL1	tolloid-like 1	Mapped by Literature SNP	TAS
COL15A1	collagen, type XV, alpha 1	Mapped by significant region	TAS
DEAF1	DEAF1 transcription factor	Mapped by Literature SNP	IEA
FGF9	fibroblast growth factor 9	Mapped by significant region	TAS
EYS	eyes shut homolog (Drosophila)	Mapped by significant region	IEA
APOA5	apolipoprotein A-V	Mapped by significant region	IDA[11577099]; TAS
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	Mapped by significant region	IEA
LIFR	leukemia inhibitory factor receptor alpha	Mapped by significant region	IEA
TCN1	transcobalamin I (vitamin B12 binding protein, R binder family)	Mapped by significant region	IEA
DHRS11	dehydrogenase/reductase (SDR family) member 11	Mapped by CNV	IEA
FGF19	fibroblast growth factor 19	Mapped by significant region	TAS
GHR	growth hormone receptor	Mapped by CNV; Mapped by significant region	TAS
OMD	osteomodulin	Mapped by significant region	TAS
TMPRSS11A	transmembrane protease, serine 11A	Mapped by significant region	IEA
TTR	transthyretin	Mapped by significant region	NAS[14718574]; TAS
PRLR	prolactin receptor	Mapped by significant region	IEA
ST14	suppression of tumorigenicity 14 (colon carcinoma)	Mapped by significant region	IEA
VEGFB	vascular endothelial growth factor B	Mapped by significant region	TAS
IGFBP5	insulin-like growth factor binding protein 5	Mapped by significant region	NAS[14718574]; TAS
CASP1	caspase 1, apoptosis-related cysteine peptidase	Mapped by significant region	IEA
LAMC1	laminin, gamma 1 (formerly LAMB2)	Mapped by significant region	TAS
C7	complement component 7	Mapped by significant region	TAS
APOC2	apolipoprotein C-II	Mapped by PBA pathway	NAS[14718574]; TAS
C5orf55	chromosome 5 open reading frame 55	Mapped by significant region	IEA
CTF1	cardiotrophin 1	Mapped by CNV	TAS[7862649]
CLEC19A	C-type lectin domain family 19, member A	Mapped by significant region	IEA
CLEC18B	C-type lectin domain family 18, member B	Mapped by significant region	IEA
GP2	glycoprotein 2 (zymogen granule membrane)	Mapped by significant region	IEA
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	Mapped by significant region	ISS; TAS
C11orf45	chromosome 11 open reading frame 45	Mapped by significant region	IEA
OLFML1	olfactomedin-like 1	Mapped by CNV	IEA
MMP10	matrix metallopeptidase 10 (stromelysin 2)	Mapped by significant region	TAS
AMBP	alpha-1-microglobulin/bikunin precursor	Mapped by significant region	NAS[11877257]
ACHE	acetylcholinesterase (Yt blood group)	Mapped by PBA pathway	IDA[1517212]; TAS[11283752]
INHA	inhibin, alpha	Mapped by significant region	TAS[12456957]
TLR9	toll-like receptor 9	Mapped by LD-proxy	NAS[11130078]
C9orf47	chromosome 9 open reading frame 47	Mapped by significant region	IEA
CXCL12	chemokine (C-X-C motif) ligand 12	Mapped by PBA pathway	TAS
NMS	neuromedin S	Mapped by CNV	TAS
TMPRSS11F	transmembrane protease, serine 11F	Mapped by significant region	IEA
KCP	kielin/chordin-like protein	Mapped by Literature SNP	IEA
REG1A	regenerating islet-derived 1 alpha	Mapped by CNV	IEA
SCG5	secretogranin V (7B2 protein)	Mapped by CNV; Mapped by significant region	IEA
PRSS53	protease, serine, 53	Mapped by CNV	IEA
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	Mapped by significant region	IEA
PLA2G2E	phospholipase A2, group IIE	Mapped by PBA pathway	TAS
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	Mapped by significant region	NAS[14718574]; TAS
PNLIP	pancreatic lipase	Mapped by PBA pathway	TAS
MTRNR2L1	MT-RNR2-like 1	Mapped by significant region	IEA
SCGB1D4	secretoglobin, family 1D, member 4	Mapped by significant region	IEA
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	Mapped by significant region	TAS
C16orf89	chromosome 16 open reading frame 89	Mapped by significant region	IEA
PNLIPRP2	pancreatic lipase-related protein 2	Mapped by PBA pathway	TAS
PLA2G2D	phospholipase A2, group IID	Mapped by PBA pathway	TAS
FN1	fibronectin 1	Mapped by significant region	NAS[14718574]; TAS
ABHD15	abhydrolase domain containing 15	Mapped by LD-proxy	IEA
STRCP1	stereocilin pseudogene 1	Mapped by LD-proxy	IEA
INS	insulin	Mapped by Literature SNP	IC[7556975]; TAS
LAMC2	laminin, gamma 2	Mapped by significant region	TAS
APOA4	apolipoprotein A-IV	Mapped by significant region	NAS[14718574]; TAS
C4orf26	chromosome 4 open reading frame 26	Mapped by CNV	IEA
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	Mapped by significant region	IDA[10077652]; NAS[10913121]; TAS
FOLR1	folate receptor 1 (adult)	Mapped by significant region	IEA
KIRREL3	kin of IRRE like 3 (Drosophila)	Mapped by significant region	ISS
MTRNR2L4	MT-RNR2-like 4	Mapped by significant region	IEA
NXPE4	neurexophilin and PC-esterase domain family, member 4	Mapped by significant region	IEA
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	Mapped by significant region	IEA
C3orf58	chromosome 3 open reading frame 58	Mapped by LD-proxy	IEA
ITIH1	inter-alpha-trypsin inhibitor heavy chain 1	Mapped by LD-proxy	NAS[14718574]
CHST9	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9	Mapped by significant region	IEA
MMP13	matrix metallopeptidase 13 (collagenase 3)	Mapped by significant region	TAS
LAMA3	laminin, alpha 3	Mapped by significant region	TAS
GSN	gelsolin	Mapped by significant region; Mapped by PBA pathway	IDA[3020431]; ISS; NAS[14718574]; TAS
APOC3	apolipoprotein C-III	Mapped by significant region	TAS
CFC1	cripto, FRL-1, cryptic family 1	Mapped by significant region	IEA
AOAH	acyloxyacyl hydrolase (neutrophil)	Mapped by PBA pathway	IEA
BTBD17	BTB (POZ) domain containing 17	Mapped by CNV	IEA
CES5A	carboxylesterase 5A	Mapped by LD-proxy	IEA
SCGB3A1	secretoglobin, family 3A, member 1	Mapped by CNV	NAS[11481438]
TUBA4A	tubulin, alpha 4a	Mapped by significant region	TAS
SVEP1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	Mapped by significant region	IEA
CMA1	chymase 1, mast cell	Mapped by significant region	TAS
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	Mapped by CNV	IEA
LTBP3	latent transforming growth factor beta binding protein 3	Mapped by significant region	IEA
IGHV1OR15-1	immunoglobulin heavy variable 1/OR15-1 (non-functional)	Mapped by significant region	NAS[2841108]
SEMA3E	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	Mapped by CNV	TAS
PRSS29P	protease, serine, 29, pseudogene	Mapped by significant region	IEA
CCL28	chemokine (C-C motif) ligand 28	Mapped by significant region	TAS
C5	complement component 5	Mapped by significant region	TAS
NCAM1	neural cell adhesion molecule 1	Mapped by significant region	IEA
TNC	tenascin C	Mapped by significant region	TAS
TPSB2	tryptase beta 2 (gene/pseudogene)	Mapped by significant region	NAS
IL7R	interleukin 7 receptor	Mapped by significant region	IEA
PLA2G3	phospholipase A2, group III	Mapped by PBA pathway	TAS
F10	coagulation factor X	Mapped by CNV	NAS[14718574]; TAS
GRP	gastrin-releasing peptide	Mapped by significant region	TAS
C10orf99	chromosome 10 open reading frame 99	Mapped by CNV	IEA
LIPF	lipase, gastric	Mapped by PBA pathway	IEA
CTSG	cathepsin G	Mapped by significant region	TAS
NELL1	NEL-like 1 (chicken)	Mapped by CNV	IEA
NMU	neuromedin U	Mapped by LD-proxy	TAS
COL27A1	collagen, type XXVII, alpha 1	Mapped by significant region	TAS
FOLR3	folate receptor 3 (gamma)	Mapped by significant region	IEA
DEFB108B	defensin, beta 108B	Mapped by significant region	IEA
GAL	galanin/GMAP prepropeptide	Mapped by CNV; Mapped by significant region	TAS
MMP11	matrix metallopeptidase 11 (stromelysin 3)	Mapped by CNV	TAS
NPC1	Niemann-Pick disease, type C1	Mapped by significant region	ISS
TMPRSS11E	transmembrane protease, serine 11E	Mapped by significant region	IEA
ISM1	isthmin 1, angiogenesis inhibitor	Mapped by CNV	IEA
COL10A1	collagen, type X, alpha 1	Mapped by significant region	TAS
PRAP1	proline-rich acidic protein 1	Mapped by Literature SNP; Mapped by CNV	IEA
SERPINI2	serpin peptidase inhibitor, clade I (pancpin), member 2	Mapped by CNV	IEA
ORM1	orosomucoid 1	Mapped by significant region	NAS[14718574]
FLT4	fms-related tyrosine kinase 4	Mapped by CNV	IEA
FOLR2	folate receptor 2 (fetal)	Mapped by significant region	IEA
OGN	osteoglycin	Mapped by significant region	TAS
NPW	neuropeptide W	Mapped by significant region	TAS
PGA5	pepsinogen 5, group I (pepsinogen A)	Mapped by significant region	IEA
C5orf38	chromosome 5 open reading frame 38	Mapped by significant region	IEA
LAMA2	laminin, alpha 2	Mapped by CNV; Mapped by significant region	TAS
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	Mapped by significant region	TAS
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	Mapped by significant region	TAS
F7	coagulation factor VII (serum prothrombin conversion accelerator)	Mapped by CNV	TAS
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mapped by CNV	IDA[12782713]
CTRB2	chymotrypsinogen B2	Mapped by significant region	TAS
SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1	Mapped by CNV	IEA
PNLIPRP1	pancreatic lipase-related protein 1	Mapped by PBA pathway	TAS[1379598]
GALNT1	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)	Mapped by significant region	IEA
COL8A1	collagen, type VIII, alpha 1	Mapped by CNV	TAS
BTC	betacellulin	Mapped by CNV	TAS
SIAE	sialic acid acetylesterase	Mapped by significant region	IEA
IGLL1	immunoglobulin lambda-like polypeptide 1	Mapped by CNV	IEA
PRSS23	protease, serine, 23	Mapped by significant region	IEA
KARS	lysyl-tRNA synthetase	Mapped by significant region	IEA
PLA2G5	phospholipase A2, group V	Mapped by PBA pathway	TAS
IL18BP	interleukin 18 binding protein	Mapped by significant region	TAS[10023777]
NPIPB15	nuclear pore complex interacting protein family, member B15	Mapped by significant region	IEA
ACP6	acid phosphatase 6, lysophosphatidic	Mapped by CNV	IEA
OLFML2B	olfactomedin-like 2B	Mapped by CNV	IEA
FCRLA	Fc receptor-like A	Mapped by CNV	IEA
HABP4	hyaluronan binding protein 4	Mapped by significant region	TAS
DEFB134	defensin, beta 134	Mapped by CNV	IEA
GLB1L	galactosidase, beta 1-like	Mapped by significant region	IEA
PDZD2	PDZ domain containing 2	Mapped by significant region	ISS[12671685]
C17orf77	chromosome 17 open reading frame 77	Mapped by CNV	IEA
CFC1B	cripto, FRL-1, cryptic family 1B	Mapped by significant region	IEA
POTEKP	POTE ankyrin domain family, member K, pseudogene	Mapped by significant region	TAS