ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005576
Name extracellular region
Type cellular component
No. of Genes in ADHDgene  267
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 267)

Literature-origin genes (count: 22)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0) TAS
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 9q34 21(12/9/0) NAS[14718574]
LPL lipoprotein lipase 8p22 1(0/0/1) TAS
CNTN4 contactin 4 3p26.3 1(1/0/0) IEA
EREG epiregulin 4q21.21 1(0/0/1) TAS
NXPH1 neurexophilin 1 7p22 1(0/1/0) IEA
GPX6 glutathione peroxidase 6 (olfactory) 6p22.1 1(0/1/0) IEA
BDNF brain-derived neurotrophic factor 11p14.1 16(8/8/0) IEA
MMP7 matrix metallopeptidase 7 (matrilysin, uterine) 11q21-q22 1(0/0/1) TAS
FGF10 fibroblast growth factor 10 5p13-p12 1(0/1/0) TAS
TLL2 tolloid-like 2 10q23-q24 1(0/0/1) IEA
GDNF glial cell derived neurotrophic factor 5p13.1-p12 2(1/1/0) IDA[9811930]
NGF nerve growth factor (beta polypeptide) 1p13.1 2(2/0/0) TAS
BCHE butyrylcholinesterase 3q26.1-q26.2 1(1/0/0) NAS[14718574]; TAS
LECT1 leukocyte cell derived chemotaxin 1 13q14.3 1(0/1/0) IEA
GFOD1 glucose-fructose oxidoreductase domain containing 1 6p24.1-p23 1(1/0/0) IEA
NCAN neurocan 19p12 1(0/1/0) TAS
NPPC natriuretic peptide C 2q37.1 1(0/1/0) NAS
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 3p21.1 1(1/0/0) NAS[14718574]
SNCA synuclein, alpha (non A4 component of amyloid precursor) 4q21.3-q22 1(0/1/0) TAS
NTF3 neurotrophin 3 12p13 4(1/3/0) IEA
STX1A syntaxin 1A (brain) 7q11.2 3(2/1/0) IEA

Genes from other sources Help (count: 245)

Approved Symbol Approved Name Source Evidence[PMID]
PGA4 pepsinogen 4, group I (pepsinogen A) Mapped by significant region IEA
PLA2G4B phospholipase A2, group IVB (cytosolic) Mapped by PBA pathway TAS[10085124]
C6orf58 chromosome 6 open reading frame 58 Mapped by significant region IEA
GPX5 glutathione peroxidase 5 (epididymal androgen-related protein) Mapped by LD-proxy IEA
IHH indian hedgehog Mapped by significant region NAS
MR1 major histocompatibility complex, class I-related Mapped by significant region IEA
IL18 interleukin 18 (interferon-gamma-inducing factor) Mapped by significant region TAS
ALDOA aldolase A, fructose-bisphosphate Mapped by CNV TAS
PRSS8 protease, serine, 8 Mapped by CNV TAS[10077646]
PLA1A phospholipase A1 member A Mapped by PBA pathway IEA
DEFB135 defensin, beta 135 Mapped by CNV IEA
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A Mapped by significant region NAS
RSPO3 R-spondin 3 Mapped by significant region IEA
APOL3 apolipoprotein L, 3 Mapped by CNV IEA
NPVF neuropeptide VF precursor Mapped by CNV; Mapped by significant region IEA
CCL19 chemokine (C-C motif) ligand 19 Mapped by LD-proxy TAS
TMEM25 transmembrane protein 25 Mapped by significant region IEA
C11orf44 chromosome 11 open reading frame 44 Mapped by significant region IEA
PYCARD PYD and CARD domain containing Mapped by CNV IEA
VASN vasorin Mapped by significant region IEA
PATE1 prostate and testis expressed 1 Mapped by significant region IEA
PTX4 pentraxin 4, long Mapped by significant region IEA
C11orf83 chromosome 11 open reading frame 83 Mapped by significant region IEA
CST6 cystatin E/M Mapped by significant region IEA
PLA2G10 phospholipase A2, group X Mapped by significant region; Mapped by PBA pathway TAS
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 Mapped by LD-proxy NAS[14718574]
TPSAB1 tryptase alpha/beta 1 Mapped by significant region TAS
FGF4 fibroblast growth factor 4 Mapped by significant region TAS
CLEC3A C-type lectin domain family 3, member A Mapped by significant region IEA
NPY neuropeptide Y Mapped by CNV; Mapped by significant region TAS
IL6 interleukin 6 (interferon, beta 2) Mapped by significant region TAS
ARSJ arylsulfatase family, member J Mapped by CNV IEA
CHRDL2 chordin-like 2 Mapped by significant region IEA
PDGFD platelet derived growth factor D Mapped by significant region TAS
SAAL1 serum amyloid A-like 1 Mapped by LD-proxy IEA
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) Mapped by PBA pathway TAS
GLB1L2 galactosidase, beta 1-like 2 Mapped by CNV; Mapped by significant region IEA
REG1B regenerating islet-derived 1 beta Mapped by CNV IEA
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin Mapped by CNV IEA
PLA2G1B phospholipase A2, group IB (pancreas) Mapped by PBA pathway TAS
ENDOD1 endonuclease domain containing 1 Mapped by significant region IEA
IGF2 insulin-like growth factor 2 (somatomedin A) Mapped by LD-proxy TAS
C9 complement component 9 Mapped by significant region TAS
WNT6 wingless-type MMTV integration site family, member 6 Mapped by significant region NAS
APOA1 apolipoprotein A-I Mapped by significant region TAS
TBC1D15 TBC1 domain family, member 15 Mapped by LD-proxy IEA
GPHA2 glycoprotein hormone alpha 2 Mapped by significant region IDA[12089349]
C6 complement component 6 Mapped by significant region TAS
IGFALS insulin-like growth factor binding protein, acid labile subunit Mapped by significant region NAS[14718574]; TAS
TSKU tsukushi, small leucine rich proteoglycan Mapped by significant region IEA
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 Mapped by Literature SNP IEA
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 Mapped by Literature SNP; Mapped by CNV TAS
CRB2 crumbs family member 2 Mapped by significant region IEA
ZG16B zymogen granule protein 16B Mapped by significant region IEA
OLFML2A olfactomedin-like 2A Mapped by significant region IEA
LGI2 leucine-rich repeat LGI family, member 2 Mapped by CNV IEA
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) Mapped by significant region IEA
KRTAP5-8 keratin associated protein 5-8 Mapped by significant region NAS
TXN thioredoxin Mapped by significant region IEA
NXPE1 neurexophilin and PC-esterase domain family, member 1 Mapped by significant region IEA
TMPRSS11D transmembrane protease, serine 11D Mapped by significant region IEA
CABP4 calcium binding protein 4 Mapped by significant region NAS[16960802]
SEPP1 selenoprotein P, plasma, 1 Mapped by CNV; Mapped by significant region NAS[14718574]
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 Mapped by significant region NAS[14718574]; TAS
CCDC126 coiled-coil domain containing 126 Mapped by CNV; Mapped by significant region IEA
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) Mapped by CNV IEA
DNASE1L2 deoxyribonuclease I-like 2 Mapped by significant region IEA
TPSD1 tryptase delta 1 Mapped by significant region IEA
DSC3 desmocollin 3 Mapped by significant region IEA
PATE3 prostate and testis expressed 3 Mapped by significant region IEA
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Mapped by significant region IEA
DNASE1 deoxyribonuclease I Mapped by significant region IEA
HPX hemopexin Mapped by CNV NAS[14718574]
NBL1 neuroblastoma 1, DAN family BMP antagonist Mapped by LD-proxy IEA
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit Mapped by significant region IEA
REG3G regenerating islet-derived 3 gamma Mapped by CNV IEA
PRSS27 protease, serine 27 Mapped by significant region IEA
XYLT1 xylosyltransferase I Mapped by CNV; Mapped by significant region IEA
CCL27 chemokine (C-C motif) ligand 27 Mapped by LD-proxy TAS
CTGF connective tissue growth factor Mapped by significant region TAS
NXPH4 neurexophilin 4 Mapped by CNV IEA
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Mapped by CNV NAS[14718574]
CLCF1 cardiotrophin-like cytokine factor 1 Mapped by significant region IDA[10966616]; NAS[10448081]
GFER growth factor, augmenter of liver regeneration Mapped by significant region IEA
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 Mapped by significant region IEA
TMPRSS11B transmembrane protease, serine 11B Mapped by significant region IEA
VWA3A von Willebrand factor A domain containing 3A Mapped by CNV; Mapped by significant region IEA
FGF3 fibroblast growth factor 3 Mapped by significant region TAS
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 Mapped by CNV; Mapped by significant region IEA
RESP18 regulated endocrine-specific protein 18 Mapped by significant region IEA
IGHV4OR15-8 immunoglobulin heavy variable 4/OR15-8 (non-functional) Mapped by significant region IEA
F2RL2 coagulation factor II (thrombin) receptor-like 2 Mapped by PBA pathway TAS
CTRB1 chymotrypsinogen B1 Mapped by significant region NAS; TAS
VWCE von Willebrand factor C and EGF domains Mapped by significant region IEA
FOLR4 folate receptor 4, delta (putative) Mapped by significant region IEA
PON2 paraoxonase 2 Mapped by PBA pathway IEA
DEFB136 defensin, beta 136 Mapped by CNV IEA
PRSS22 protease, serine, 22 Mapped by significant region IEA
TLL1 tolloid-like 1 Mapped by Literature SNP TAS
COL15A1 collagen, type XV, alpha 1 Mapped by significant region TAS
DEAF1 DEAF1 transcription factor Mapped by Literature SNP IEA
FGF9 fibroblast growth factor 9 Mapped by significant region TAS
EYS eyes shut homolog (Drosophila) Mapped by significant region IEA
APOA5 apolipoprotein A-V Mapped by significant region IDA[11577099]; TAS
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 Mapped by significant region IEA
LIFR leukemia inhibitory factor receptor alpha Mapped by significant region IEA
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) Mapped by significant region IEA
DHRS11 dehydrogenase/reductase (SDR family) member 11 Mapped by CNV IEA
FGF19 fibroblast growth factor 19 Mapped by significant region TAS
GHR growth hormone receptor Mapped by CNV; Mapped by significant region TAS
OMD osteomodulin Mapped by significant region TAS
TMPRSS11A transmembrane protease, serine 11A Mapped by significant region IEA
TTR transthyretin Mapped by significant region NAS[14718574]; TAS
PRLR prolactin receptor Mapped by significant region IEA
ST14 suppression of tumorigenicity 14 (colon carcinoma) Mapped by significant region IEA
VEGFB vascular endothelial growth factor B Mapped by significant region TAS
IGFBP5 insulin-like growth factor binding protein 5 Mapped by significant region NAS[14718574]; TAS
CASP1 caspase 1, apoptosis-related cysteine peptidase Mapped by significant region IEA
LAMC1 laminin, gamma 1 (formerly LAMB2) Mapped by significant region TAS
C7 complement component 7 Mapped by significant region TAS
APOC2 apolipoprotein C-II Mapped by PBA pathway NAS[14718574]; TAS
C5orf55 chromosome 5 open reading frame 55 Mapped by significant region IEA
CTF1 cardiotrophin 1 Mapped by CNV TAS[7862649]
CLEC19A C-type lectin domain family 19, member A Mapped by significant region IEA
CLEC18B C-type lectin domain family 18, member B Mapped by significant region IEA
GP2 glycoprotein 2 (zymogen granule membrane) Mapped by significant region IEA
IGFBP2 insulin-like growth factor binding protein 2, 36kDa Mapped by significant region ISS; TAS
C11orf45 chromosome 11 open reading frame 45 Mapped by significant region IEA
OLFML1 olfactomedin-like 1 Mapped by CNV IEA
MMP10 matrix metallopeptidase 10 (stromelysin 2) Mapped by significant region TAS
AMBP alpha-1-microglobulin/bikunin precursor Mapped by significant region NAS[11877257]
ACHE acetylcholinesterase (Yt blood group) Mapped by PBA pathway IDA[1517212]; TAS[11283752]
INHA inhibin, alpha Mapped by significant region TAS[12456957]
TLR9 toll-like receptor 9 Mapped by LD-proxy NAS[11130078]
C9orf47 chromosome 9 open reading frame 47 Mapped by significant region IEA
CXCL12 chemokine (C-X-C motif) ligand 12 Mapped by PBA pathway TAS
NMS neuromedin S Mapped by CNV TAS
TMPRSS11F transmembrane protease, serine 11F Mapped by significant region IEA
KCP kielin/chordin-like protein Mapped by Literature SNP IEA
REG1A regenerating islet-derived 1 alpha Mapped by CNV IEA
SCG5 secretogranin V (7B2 protein) Mapped by CNV; Mapped by significant region IEA
PRSS53 protease, serine, 53 Mapped by CNV IEA
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 Mapped by significant region IEA
PLA2G2E phospholipase A2, group IIE Mapped by PBA pathway TAS
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 Mapped by significant region NAS[14718574]; TAS
PNLIP pancreatic lipase Mapped by PBA pathway TAS
MTRNR2L1 MT-RNR2-like 1 Mapped by significant region IEA
SCGB1D4 secretoglobin, family 1D, member 4 Mapped by significant region IEA
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) Mapped by significant region TAS
C16orf89 chromosome 16 open reading frame 89 Mapped by significant region IEA
PNLIPRP2 pancreatic lipase-related protein 2 Mapped by PBA pathway TAS
PLA2G2D phospholipase A2, group IID Mapped by PBA pathway TAS
FN1 fibronectin 1 Mapped by significant region NAS[14718574]; TAS
ABHD15 abhydrolase domain containing 15 Mapped by LD-proxy IEA
STRCP1 stereocilin pseudogene 1 Mapped by LD-proxy IEA
INS insulin Mapped by Literature SNP IC[7556975]; TAS
LAMC2 laminin, gamma 2 Mapped by significant region TAS
APOA4 apolipoprotein A-IV Mapped by significant region NAS[14718574]; TAS
C4orf26 chromosome 4 open reading frame 26 Mapped by CNV IEA
PAPPA pregnancy-associated plasma protein A, pappalysin 1 Mapped by significant region IDA[10077652]; NAS[10913121]; TAS
FOLR1 folate receptor 1 (adult) Mapped by significant region IEA
KIRREL3 kin of IRRE like 3 (Drosophila) Mapped by significant region ISS
MTRNR2L4 MT-RNR2-like 4 Mapped by significant region IEA
NXPE4 neurexophilin and PC-esterase domain family, member 4 Mapped by significant region IEA
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) Mapped by significant region IEA
C3orf58 chromosome 3 open reading frame 58 Mapped by LD-proxy IEA
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 Mapped by LD-proxy NAS[14718574]
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 Mapped by significant region IEA
MMP13 matrix metallopeptidase 13 (collagenase 3) Mapped by significant region TAS
LAMA3 laminin, alpha 3 Mapped by significant region TAS
GSN gelsolin Mapped by significant region; Mapped by PBA pathway IDA[3020431]; ISS; NAS[14718574]; TAS
APOC3 apolipoprotein C-III Mapped by significant region TAS
CFC1 cripto, FRL-1, cryptic family 1 Mapped by significant region IEA
AOAH acyloxyacyl hydrolase (neutrophil) Mapped by PBA pathway IEA
BTBD17 BTB (POZ) domain containing 17 Mapped by CNV IEA
CES5A carboxylesterase 5A Mapped by LD-proxy IEA
SCGB3A1 secretoglobin, family 3A, member 1 Mapped by CNV NAS[11481438]
TUBA4A tubulin, alpha 4a Mapped by significant region TAS
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Mapped by significant region IEA
CMA1 chymase 1, mast cell Mapped by significant region TAS
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) Mapped by CNV IEA
LTBP3 latent transforming growth factor beta binding protein 3 Mapped by significant region IEA
IGHV1OR15-1 immunoglobulin heavy variable 1/OR15-1 (non-functional) Mapped by significant region NAS[2841108]
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E Mapped by CNV TAS
PRSS29P protease, serine, 29, pseudogene Mapped by significant region IEA
CCL28 chemokine (C-C motif) ligand 28 Mapped by significant region TAS
C5 complement component 5 Mapped by significant region TAS
NCAM1 neural cell adhesion molecule 1 Mapped by significant region IEA
TNC tenascin C Mapped by significant region TAS
TPSB2 tryptase beta 2 (gene/pseudogene) Mapped by significant region NAS
IL7R interleukin 7 receptor Mapped by significant region IEA
PLA2G3 phospholipase A2, group III Mapped by PBA pathway TAS
F10 coagulation factor X Mapped by CNV NAS[14718574]; TAS
GRP gastrin-releasing peptide Mapped by significant region TAS
C10orf99 chromosome 10 open reading frame 99 Mapped by CNV IEA
LIPF lipase, gastric Mapped by PBA pathway IEA
CTSG cathepsin G Mapped by significant region TAS
NELL1 NEL-like 1 (chicken) Mapped by CNV IEA
NMU neuromedin U Mapped by LD-proxy TAS
COL27A1 collagen, type XXVII, alpha 1 Mapped by significant region TAS
FOLR3 folate receptor 3 (gamma) Mapped by significant region IEA
DEFB108B defensin, beta 108B Mapped by significant region IEA
GAL galanin/GMAP prepropeptide Mapped by CNV; Mapped by significant region TAS
MMP11 matrix metallopeptidase 11 (stromelysin 3) Mapped by CNV TAS
NPC1 Niemann-Pick disease, type C1 Mapped by significant region ISS
TMPRSS11E transmembrane protease, serine 11E Mapped by significant region IEA
ISM1 isthmin 1, angiogenesis inhibitor Mapped by CNV IEA
COL10A1 collagen, type X, alpha 1 Mapped by significant region TAS
PRAP1 proline-rich acidic protein 1 Mapped by Literature SNP; Mapped by CNV IEA
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 Mapped by CNV IEA
ORM1 orosomucoid 1 Mapped by significant region NAS[14718574]
FLT4 fms-related tyrosine kinase 4 Mapped by CNV IEA
FOLR2 folate receptor 2 (fetal) Mapped by significant region IEA
OGN osteoglycin Mapped by significant region TAS
NPW neuropeptide W Mapped by significant region TAS
PGA5 pepsinogen 5, group I (pepsinogen A) Mapped by significant region IEA
C5orf38 chromosome 5 open reading frame 38 Mapped by significant region IEA
LAMA2 laminin, alpha 2 Mapped by CNV; Mapped by significant region TAS
MMP8 matrix metallopeptidase 8 (neutrophil collagenase) Mapped by significant region TAS
MMP1 matrix metallopeptidase 1 (interstitial collagenase) Mapped by significant region TAS
F7 coagulation factor VII (serum prothrombin conversion accelerator) Mapped by CNV TAS
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mapped by CNV IDA[12782713]
CTRB2 chymotrypsinogen B2 Mapped by significant region TAS
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 Mapped by CNV IEA
PNLIPRP1 pancreatic lipase-related protein 1 Mapped by PBA pathway TAS[1379598]
GALNT1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) Mapped by significant region IEA
COL8A1 collagen, type VIII, alpha 1 Mapped by CNV TAS
BTC betacellulin Mapped by CNV TAS
SIAE sialic acid acetylesterase Mapped by significant region IEA
IGLL1 immunoglobulin lambda-like polypeptide 1 Mapped by CNV IEA
PRSS23 protease, serine, 23 Mapped by significant region IEA
KARS lysyl-tRNA synthetase Mapped by significant region IEA
PLA2G5 phospholipase A2, group V Mapped by PBA pathway TAS
IL18BP interleukin 18 binding protein Mapped by significant region TAS[10023777]
NPIPB15 nuclear pore complex interacting protein family, member B15 Mapped by significant region IEA
ACP6 acid phosphatase 6, lysophosphatidic Mapped by CNV IEA
OLFML2B olfactomedin-like 2B Mapped by CNV IEA
FCRLA Fc receptor-like A Mapped by CNV IEA
HABP4 hyaluronan binding protein 4 Mapped by significant region TAS
DEFB134 defensin, beta 134 Mapped by CNV IEA
GLB1L galactosidase, beta 1-like Mapped by significant region IEA
PDZD2 PDZ domain containing 2 Mapped by significant region ISS[12671685]
C17orf77 chromosome 17 open reading frame 77 Mapped by CNV IEA
CFC1B cripto, FRL-1, cryptic family 1B Mapped by significant region IEA
POTEKP POTE ankyrin domain family, member K, pseudogene Mapped by significant region TAS