ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NCAM1
Symbol Alias	NCAM, CD56
Approved Name	neural cell adhesion molecule 1
Location	11q23-q24
Position	chr11:112831995-113149158, +
External Links	HGNC: 7656 Entrez Gene: 4684 Ensembl: ENSG00000149294 UCSC: uc001pnq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0060333	interferon-gamma-mediated signaling pathway	Biological Process		8
GO:0043025	neuronal cell body	Cellular Component		51
GO:0050850	positive regulation of calcium-mediated signaling	Biological Process		7
GO:0001928	regulation of exocyst assembly	Biological Process		1
GO:0000139	Golgi membrane	Cellular Component		95
GO:0007411	axon guidance	Biological Process		65
GO:0007155	cell adhesion	Biological Process	NAS[10770948]	86
GO:0005886	plasma membrane	Cellular Component		772
GO:0005576	extracellular region	Cellular Component		240
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0016021	integral to membrane	Cellular Component		845
GO:0009986	cell surface	Cellular Component	IDA[10766765]	70
GO:0009897	external side of plasma membrane	Cellular Component	IDA[17213291]	34
GO:0034109	homotypic cell-cell adhesion	Biological Process		1
GO:0031225	anchored to membrane	Cellular Component		29
GO:0030426	growth cone	Cellular Component		20
GO:0030424	axon	Cellular Component		35

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...
hsa05020	Prion diseases	11	Prion diseases, also termed transmissible spongiform encepha...... Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC. More...

Genes shared at least 5 GO terms with NCAM1 (count: 9)

Gene Symbol	Pathway Count	Pathway List
ACHE	6	cell adhesion; plasma membrane; extracellular region; cell surface; anchored to membrane; axon;
HLA-DRB1	5	interferon-gamma-mediated signaling pathway; Golgi membrane; plasma membrane; cytokine-mediated signaling pathway; external side of plasma membrane;
CNTNAP2	5	neuronal cell body; cell adhesion; integral to membrane; cell surface; axon;
EPHA5	5	neuronal cell body; axon guidance; plasma membrane; external side of plasma membrane; axon;
GHR	5	neuronal cell body; plasma membrane; extracellular region; integral to membrane; cell surface;
PTPRK	5	neuronal cell body; cell adhesion; integral to membrane; cell surface; axon;
CNTN4	5	axon guidance; plasma membrane; extracellular region; anchored to membrane; axon;
ITGA2	5	axon guidance; cell adhesion; plasma membrane; cell surface; external side of plasma membrane;
NRXN1	5	axon guidance; cell adhesion; plasma membrane; integral to membrane; cell surface;

Genes shared at least 2 KEGG pathways with NCAM1 (count: 0)

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Region: chr11:112831995..113149158 View in gBrowse