ADHDgene Database

Gene Report

Basic Info

Approved Symbol	EPHA5
Symbol Alias	Hek7, TYRO4, CEK7, EHK1
Approved Name	EPH receptor A5
Previous Name	EphA5
Location	4q13.1
Position	chr4:66185281-66536213, -
External Links	HGNC: 3389 Entrez Gene: 2044 Ensembl: ENSG00000145242 UCSC: uc003hcy.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_27	chr4:65846170-66521854 (NCBI Build 36.1 (hg18))	675685	4q13.1-4q13.2	Gain
CNV_Williams[2010]_31	chr4:65791505-66605654 (NCBI Build 36.1 (hg18))	1246268	4q13.1-4q13.2	Gain	De novo

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
4q13.1	chr4:59500000-66600000	1 (1/0/0)

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005003	ephrin receptor activity	Molecular Function		2
GO:0005004	GPI-linked ephrin receptor activity	Molecular Function		1
GO:0005005	transmembrane-ephrin receptor activity	Molecular Function	NAS[7898931]	1
GO:0005524	ATP binding	Molecular Function		228
GO:0051964	negative regulation of synapse assembly	Biological Process		2
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Biological Process		3
GO:0048013	ephrin receptor signaling pathway	Biological Process		2
GO:0043025	neuronal cell body	Cellular Component	IDA[10375373]	51
GO:0048666	neuron development	Biological Process	IEP[10375373]	7
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[10375373]	87
GO:0032314	regulation of Rac GTPase activity	Biological Process		4
GO:0030425	dendrite	Cellular Component	IDA[10375373]	46
GO:0032956	regulation of actin cytoskeleton organization	Biological Process		6
GO:0032793	positive regulation of CREB transcription factor activity	Biological Process		6
GO:0019933	cAMP-mediated signaling	Biological Process		3
GO:0009897	external side of plasma membrane	Cellular Component	IDA[10064801]	34
GO:0030424	axon	Cellular Component		35
GO:0021766	hippocampus development	Biological Process		7
GO:0005886	plasma membrane	Cellular Component	IDA[10375373]	772
GO:0005791	rough endoplasmic reticulum	Cellular Component	IDA[10375373]	7
GO:0007411	axon guidance	Biological Process		65
GO:0005887	integral to plasma membrane	Cellular Component		220

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04360	Axon guidance	25	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...

Genes shared at least 5 GO terms with EPHA5 (count: 5)

Gene Symbol	Pathway Count	Pathway List
GSK3B	6	ATP binding; neuronal cell body; perinuclear region of cytoplasm; hippocampus development; plasma membrane; axon guidance;
HTR5A	6	dendrite; cAMP-mediated signaling; hippocampus development; plasma membrane; rough endoplasmic reticulum; integral to plasma membrane;
PAK1	5	ATP binding; dendrite; axon; plasma membrane; axon guidance;
NCAM1	5	neuronal cell body; external side of plasma membrane; axon; plasma membrane; axon guidance;
PDE2A	5	perinuclear region of cytoplasm; dendrite; cAMP-mediated signaling; axon; plasma membrane;

Genes shared at least 2 KEGG pathways with EPHA5 (count: 0)

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Region: chr4:66185281..66536213 View in gBrowse