ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04360
Name Axon guidance
No. of Genes in ADHDgene  26
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 26)

Literature-origin genes (count: 4)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 12q13.13 1(0/0/1)
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0)
UNC5B unc-5 homolog B (C. elegans) 10q22.2 1(0/0/1)
SLIT1 slit homolog 1 (Drosophila) 10q23.3-q24 1(0/0/1)

Genes from other sources Help(count: 22)

Approved Symbol Approved Name Location Source
CFL1 cofilin 1 (non-muscle) 11q13.1 Mapped by significant region
RASA1 RAS p21 protein activator (GTPase activating protein) 1 5q13 Mapped by PBA pathway
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 11q23.3 Mapped by significant region
RHOD ras homolog family member D 11q14.3 Mapped by significant region
FES feline sarcoma oncogene 15q26.1 Mapped by LD-proxy
CXCL12 chemokine (C-X-C motif) ligand 12 10q11.1 Mapped by PBA pathway
EPHA6 EPH receptor A6 3q12.1 Mapped by CNV
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 11q24 Mapped by significant region
RGS3 regulator of G-protein signaling 3 9q32 Mapped by significant region
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 2p24 Mapped by significant region
NCK2 NCK adaptor protein 2 2q12 Mapped by PBA pathway
EPHA5 EPH receptor A5 4q13.1 Mapped by CNV; Mapped by significant region
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 9q22-q31 Mapped by significant region
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 20p12 Mapped by CNV
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 5p15.2 Mapped by significant region
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 7q21.11 Mapped by CNV
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 14q11.2 Mapped by significant region
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 9q31 Mapped by significant region
NCK1 NCK adaptor protein 1 3q21 Mapped by PBA pathway
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 11q13-q14 Mapped by significant region