ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04360
Name Axon guidance
Description  Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
No. of Genes in ADHDgene  25
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 25)

Literature-origin genes (count: 4)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0)
UNC5B unc-5 homolog B (C. elegans) 10q22.2 1(0/0/1)
SLIT1 slit homolog 1 (Drosophila) 10q23.3-q24 1(0/0/1)
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 12q13.13 1(0/0/1)

Genes from other sources Help(count: 21)

Approved Symbol Approved Name Location Source
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 7q21.11 Mapped by CNV
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 14q11.2 Mapped by significant region
EPHA5 EPH receptor A5 4q13.1 Mapped by CNV; Mapped by significant region
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
NCK1 NCK adaptor protein 1 3q21 Mapped by PBA pathway
NCK2 NCK adaptor protein 2 2q12 Mapped by PBA pathway
FES feline sarcoma oncogene 15q25-qter Mapped by LD-proxy
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 20p12 Mapped by CNV
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 9q31 Mapped by significant region
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 11q24 Mapped by significant region
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 2p24 Mapped by significant region
RHOD ras homolog gene family, member D 11q14.3 Mapped by significant region
EPHA6 EPH receptor A6 3q12.1 Mapped by CNV
RASA1 RAS p21 protein activator (GTPase activating protein) 1 5q13 Mapped by PBA pathway
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 11q13-q14 Mapped by significant region
RGS3 regulator of G-protein signaling 3 9q32 Mapped by significant region
CFL1 cofilin 1 (non-muscle) 11q13.1 Mapped by significant region
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 11q23.3 Mapped by significant region
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 9q22-q31 Mapped by significant region
CXCL12 chemokine (C-X-C motif) ligand 12 10q11.1 Mapped by PBA pathway

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014