ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FES
Symbol Alias	FPS
Approved Name	feline sarcoma oncogene
Previous Name	feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
Name Alias	Oncogene FES, feline sarcoma virus, "c-fes/fps protein"
Location	15q25-qter
Position	chr15:91426925-91439006, +
External Links	HGNC: 3657 Entrez Gene: 2242 Ensembl: ENSG00000182511 UCSC: uc002bpv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 5)

Literature-origin SNPs (count: 0)

LD-proxies (count: 5)

rs_ID	Location	Functional Annotation
rs1894400	Chr15:91428955(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs6227	Chr15:91425232(Fwd)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs2521498	Chr15:91442152(Fwd)	downstream_gene_variant; upstream_gene_variant
rs1029420	Chr15:91441086(Fwd)	downstream_gene_variant; upstream_gene_variant
rs2521501	Chr15:91437388(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005524	ATP binding	Molecular Function		228
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function	IDA[15485904]	6
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005737	cytoplasm	Cellular Component	IDA[11339827]	690
GO:0004713	protein tyrosine kinase activity	Molecular Function	IDA[11509660]	10
GO:0008283	cell proliferation	Biological Process	TAS[6264598]	60
GO:0007411	axon guidance	Biological Process		65
GO:0010976	positive regulation of neuron projection development	Biological Process	IMP[15302586]	9
GO:0008360	regulation of cell shape	Biological Process	IMP[18046454]	20
GO:0005925	focal adhesion	Cellular Component	IDA[18046454]	26
GO:0005829	cytosol	Cellular Component		447
GO:0007275	multicellular organismal development	Biological Process	TAS[6264598]	71
GO:0006468	protein phosphorylation	Biological Process	TAS[6183005]	53
GO:0031410	cytoplasmic vesicle	Cellular Component	IDA[11339827]	20
GO:0034987	immunoglobulin receptor binding	Molecular Function	IDA[19001085]	1
GO:0031116	positive regulation of microtubule polymerization	Biological Process	IMP[15485904]	6
GO:0031234	extrinsic to internal side of plasma membrane	Cellular Component	IDA[18046454]	5
GO:0018108	peptidyl-tyrosine phosphorylation	Biological Process	IDA[11509660]	3
GO:0030155	regulation of cell adhesion	Biological Process	IMP[11509660]	8
GO:0015630	microtubule cytoskeleton	Cellular Component	IDA[15485904]	34
GO:0016023	cytoplasmic membrane-bounded vesicle	Cellular Component		16
GO:0060627	regulation of vesicle-mediated transport	Biological Process	TAS[11339827]	2
GO:2000145	regulation of cell motility	Biological Process	IMP[18046454]	2
GO:0045639	positive regulation of myeloid cell differentiation	Biological Process	IMP[2656706]	2
GO:0046777	protein autophosphorylation	Biological Process	IDA[7687763]	23
GO:0043304	regulation of mast cell degranulation	Biological Process	IMP[19001085]	1
GO:0045595	regulation of cell differentiation	Biological Process	IMP[15302586]	6
GO:0035091	phosphatidylinositol binding	Molecular Function	IDA[19001085]	13
GO:0042127	regulation of cell proliferation	Biological Process	IMP[11509660]	20
GO:2000251	positive regulation of actin cytoskeleton reorganization	Biological Process	IMP[15302586]	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04360	Axon guidance	25	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...

Genes shared at least 5 GO terms with FES (count: 15)

Gene Symbol	Pathway Count	Pathway List
PAK1	8	ATP binding; Golgi apparatus; cytoplasm; axon guidance; focal adhesion; cytosol; protein phosphorylation; protein autophosphorylation;
MAPK1	7	ATP binding; Golgi apparatus; cytoplasm; axon guidance; focal adhesion; cytosol; microtubule cytoskeleton;
MAPK3	7	ATP binding; Golgi apparatus; axon guidance; focal adhesion; cytosol; protein phosphorylation; microtubule cytoskeleton;
PRKD1	7	ATP binding; Golgi apparatus; cytoplasm; cell proliferation; positive regulation of neuron projection development; cytosol; protein autophosphorylation;
SYK	7	ATP binding; non-membrane spanning protein tyrosine kinase activity; cell proliferation; cytosol; protein phosphorylation; peptidyl-tyrosine phosphorylation; protein autophosphorylation;
YES1	7	ATP binding; non-membrane spanning protein tyrosine kinase activity; Golgi apparatus; cytoplasm; protein tyrosine kinase activity; cytosol; protein autophosphorylation;
ERBB2	6	ATP binding; protein tyrosine kinase activity; cell proliferation; axon guidance; protein phosphorylation; protein autophosphorylation;
ILK	6	ATP binding; cytoplasm; cell proliferation; focal adhesion; cytosol; protein phosphorylation;
MAP3K11	6	ATP binding; cytoplasm; protein tyrosine kinase activity; cell proliferation; protein phosphorylation; protein autophosphorylation;
ROCK2	6	ATP binding; axon guidance; cytosol; protein phosphorylation; regulation of cell adhesion; regulation of cell motility;
CCDC88A	6	Golgi apparatus; cytosol; cytoplasmic vesicle; cytoplasmic membrane-bounded vesicle; phosphatidylinositol binding; regulation of cell proliferation;
GSK3B	5	ATP binding; cytoplasm; axon guidance; cytosol; protein phosphorylation;
PRKG1	5	ATP binding; Golgi apparatus; cytoplasm; cytosol; protein phosphorylation;
SIK2	5	ATP binding; Golgi apparatus; cytoplasm; protein phosphorylation; protein autophosphorylation;
TSSK2	5	ATP binding; cytoplasm; multicellular organismal development; protein phosphorylation; protein autophosphorylation;

Genes shared at least 2 KEGG pathways with FES (count: 0)

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Region: chr15:91426925..91439006 View in gBrowse