ADHDgene Database

Gene Report

Basic Info

Approved Symbol	YES1
Symbol Alias	Yes, c-yes, HsT441
Approved Name	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Location	18p11.31-p11.21
Position	chr18:721588-812547, -1
External Links	HGNC: 12841 Entrez Gene: 7525 Ensembl: ENSG00000176105 UCSC: uc002kky.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_200	chr18:727083-890523 (NCBI Build 35 (hg17))	163441	18p11.32	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006464	cellular protein modification process	biological process	TAS[2436037]	15
GO:0050900	leukocyte migration	biological process	TAS	13
GO:0044325	ion channel binding	molecular function	IPI[12538589]	16
GO:0005154	epidermal growth factor receptor binding	molecular function	IEA	4
GO:0005886	plasma membrane	cellular component	IDA	839
GO:0043114	regulation of vascular permeability	biological process	TAS[19267251]	2
GO:0046777	protein autophosphorylation	biological process	IEA	26
GO:0005794	Golgi apparatus	cellular component	IDA	174
GO:0005815	microtubule organizing center	cellular component	IEA	21
GO:0019899	enzyme binding	molecular function	IPI	54
GO:0015758	glucose transport	biological process	IEA	14
GO:0031295	T cell costimulation	biological process	TAS	16
GO:0005829	cytosol	cellular component	TAS	485
GO:0004715	non-membrane spanning protein tyrosine kinase activity	molecular function	TAS[19267251]	6
GO:0007596	blood coagulation	biological process	TAS	85
GO:0004713	protein tyrosine kinase activity	molecular function	EXP; TAS	11
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0005524	ATP binding	molecular function	IEA	265

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04520	Adherens junction	15
hsa04530	Tight junction	19

Genes shared at least 5 GO terms with YES1 (count: 13)

Gene Symbol	Pathway Count	Pathway List
PDPK1	7	plasma membrane; protein autophosphorylation; T cell costimulation; cytosol; blood coagulation; cytoplasm; ATP binding;
PAK1	7	plasma membrane; protein autophosphorylation; Golgi apparatus; T cell costimulation; cytosol; cytoplasm; ATP binding;
FES	7	protein autophosphorylation; Golgi apparatus; cytosol; non-membrane spanning protein tyrosine kinase activity; protein tyrosine kinase activity; cytoplasm; ATP binding;
SYK	6	plasma membrane; protein autophosphorylation; cytosol; non-membrane spanning protein tyrosine kinase activity; blood coagulation; ATP binding;
PRKG1	6	plasma membrane; Golgi apparatus; cytosol; blood coagulation; cytoplasm; ATP binding;
PRKD1	6	plasma membrane; protein autophosphorylation; Golgi apparatus; cytosol; cytoplasm; ATP binding;
MAPK1	6	Golgi apparatus; microtubule organizing center; cytosol; blood coagulation; cytoplasm; ATP binding;
PIK3R1	5	leukocyte migration; plasma membrane; T cell costimulation; cytosol; blood coagulation;
PDE2A	5	plasma membrane; Golgi apparatus; cytosol; blood coagulation; cytoplasm;
WWOX	5	plasma membrane; Golgi apparatus; enzyme binding; cytosol; cytoplasm;
CLASP2	5	plasma membrane; Golgi apparatus; microtubule organizing center; cytosol; cytoplasm;
PIK3CG	5	plasma membrane; cytosol; blood coagulation; cytoplasm; ATP binding;
SCYL1	5	Golgi apparatus; microtubule organizing center; protein tyrosine kinase activity; cytoplasm; ATP binding;

Genes shared at least 2 KEGG pathways with YES1 (count: 4)

Gene Symbol	Pathway Count	Pathway List
CTNNA2	2	Adherens junction; Tight junction;
ACTN3	2	Adherens junction; Tight junction;
CTNNA3	2	Adherens junction; Tight junction;
TJP1	2	Adherens junction; Tight junction;

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Region: chr18:721588..812547 View in gBrowse