ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TJP1
Symbol Alias	ZO-1, MGC133289, DKFZp686M05161
Approved Name	tight junction protein 1
Name Alias	"zona occludens 1", "tight junction protein ZO-1"
Location	15q13
Position	chr15:29991571-30261068, -1
External Links	HGNC: 11827 Entrez Gene: 7082 Ensembl: ENSG00000104067 UCSC: uc001zcr.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type
CNV_Williams[2010]_51	chr15:27000239-28153539 (NCBI Build 36.1 (hg18))	1153301	15q13.1-15q13.2	Gain
CNV_Williams[2010]_47	chr15:27013177-28153539 (NCBI Build 36.1 (hg18))	1140363	15q13.1-15q13.2	Gain
CNV_Jarick[2012]_29	chr15:27216380-28153539 (NCBI36 / hg18)	937160	15q13.1-15q13.2	dup

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
15q11.2-13.3	chr15:20700000-33600000	1 (1/0/0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045471	response to ethanol	biological process	IEA	18
GO:0016327	apicolateral plasma membrane	cellular component	IEA	1
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	biological process	TAS	9
GO:0045177	apical part of cell	cellular component	IDA	11
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0019904	protein domain specific binding	molecular function	IEA	43
GO:0005634	nucleus	cellular component	IEA	877
GO:0043296	apical junction complex	cellular component	IDA[16427635]	1
GO:1901350	cell-cell signaling involved in cell-cell junction organization	biological process	NAS[8395056]	1
GO:0071333	cellular response to glucose stimulus	biological process	IEA	8
GO:0005921	gap junction	cellular component	IEA	7
GO:0032496	response to lipopolysaccharide	biological process	IEA	23
GO:0042493	response to drug	biological process	IEA	73
GO:0035329	hippo signaling cascade	biological process	TAS	5
GO:0001825	blastocyst formation	biological process	IEA	2
GO:0014704	intercalated disc	cellular component	IEA	10
GO:0005829	cytosol	cellular component	TAS	485
GO:0005923	tight junction	cellular component	IDA[14757759]	18
GO:0005913	cell-cell adherens junction	cellular component	IEA	9
GO:0046581	intercellular canaliculus	cellular component	IEA	1
GO:0006915	apoptotic process	biological process	TAS	127
GO:0008022	protein C-terminus binding	molecular function	IEA	42
GO:0016323	basolateral plasma membrane	cellular component	IDA[16427635]	32
GO:0005515	protein binding	molecular function	IPI[16944923]	1015
GO:0071000	response to magnetism	biological process	IEA	1
GO:0043116	negative regulation of vascular permeability	biological process	IEA	4
GO:0005886	plasma membrane	cellular component	IDA; TAS	839
GO:0007043	cell-cell junction assembly	biological process	TAS[8486731]	3
GO:0030054	cell junction	cellular component	IDA	84
GO:0005516	calmodulin binding	molecular function	IEA	33

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14
hsa04520	Adherens junction	15
hsa05110	Vibrio cholerae infection	11
hsa04540	Gap junction	30
hsa04530	Tight junction	19

Genes shared at least 5 GO terms with TJP1 (count: 67)

Gene Symbol	Pathway Count	Pathway List
APC	9	cellular component disassembly involved in execution phase of apoptosis; cytoplasm; nucleus; cytosol; tight junction; cell-cell adherens junction; apoptotic process; protein binding; plasma membrane;
SNCA	9	cytoplasm; protein domain specific binding; nucleus; response to lipopolysaccharide; response to drug; cytosol; protein binding; plasma membrane; cell junction;
TH	8	response to ethanol; cytoplasm; protein domain specific binding; nucleus; cellular response to glucose stimulus; response to lipopolysaccharide; cytosol; protein binding;
ARRB2	7	cytoplasm; protein domain specific binding; nucleus; cytosol; basolateral plasma membrane; protein binding; plasma membrane;
BAIAP2	7	cytoplasm; nucleus; cytosol; protein C-terminus binding; protein binding; plasma membrane; cell junction;
AXIN1	7	cytoplasm; nucleus; cytosol; apoptotic process; protein C-terminus binding; protein binding; plasma membrane;
CTNND1	7	cytoplasm; protein domain specific binding; nucleus; cytosol; cell-cell adherens junction; protein binding; plasma membrane;
DRD3	6	response to ethanol; apical part of cell; protein domain specific binding; response to drug; protein binding; plasma membrane;
CCND1	6	response to ethanol; nucleus; response to drug; cytosol; tight junction; protein binding;
PAK1	6	cytoplasm; intercalated disc; cytosol; apoptotic process; protein binding; plasma membrane;
AMOTL1	6	cytoplasm; hippo signaling cascade; cytosol; tight junction; protein binding; cell junction;
PRKD1	6	cytoplasm; nucleus; cytosol; apoptotic process; protein binding; plasma membrane;
NCK1	6	cytoplasm; protein domain specific binding; nucleus; cytosol; protein binding; plasma membrane;
PICK1	6	cytoplasm; protein domain specific binding; protein C-terminus binding; protein binding; plasma membrane; cell junction;
WWOX	6	cytoplasm; nucleus; cytosol; apoptotic process; protein binding; plasma membrane;
GSK3B	6	cytoplasm; nucleus; response to drug; cytosol; protein binding; plasma membrane;
STXBP3	6	cytoplasm; nucleus; cytosol; basolateral plasma membrane; protein binding; plasma membrane;
PDE2A	6	cytoplasm; nucleus; cytosol; protein binding; negative regulation of vascular permeability; plasma membrane;
NCF2	6	cytoplasm; response to lipopolysaccharide; response to drug; cytosol; protein C-terminus binding; protein binding;
AKAP7	6	protein domain specific binding; nucleus; cytosol; protein C-terminus binding; protein binding; plasma membrane;
GRIN2A	5	response to ethanol; response to drug; protein binding; plasma membrane; cell junction;
BAD	5	response to ethanol; response to drug; cytosol; apoptotic process; protein binding;
SLC6A3	5	response to ethanol; cytoplasm; response to drug; protein binding; plasma membrane;
GSN	5	response to ethanol; cellular component disassembly involved in execution phase of apoptosis; cytosol; apoptotic process; protein binding;
MAPT	5	cellular component disassembly involved in execution phase of apoptosis; cytosol; apoptotic process; protein binding; plasma membrane;
PMAIP1	5	cellular component disassembly involved in execution phase of apoptosis; nucleus; cytosol; apoptotic process; protein binding;
BIRC2	5	cellular component disassembly involved in execution phase of apoptosis; nucleus; cytosol; apoptotic process; protein binding;
DSG1	5	cellular component disassembly involved in execution phase of apoptosis; cytosol; apoptotic process; plasma membrane; cell-cell junction assembly;
NUMA1	5	apical part of cell; cytoplasm; nucleus; cytosol; protein binding;
CBL	5	cytoplasm; nucleus; cytosol; protein binding; plasma membrane;
CTNNA2	5	cytoplasm; cytosol; cell-cell adherens junction; basolateral plasma membrane; protein binding;
GOPC	5	cytoplasm; protein C-terminus binding; protein binding; plasma membrane; cell junction;
PERP	5	cytoplasm; nucleus; apoptotic process; plasma membrane; cell junction;
BLMH	5	cytoplasm; nucleus; response to drug; cytosol; protein binding;
MGRN1	5	cytoplasm; nucleus; cytosol; protein binding; plasma membrane;
RELA	5	cytoplasm; nucleus; response to drug; cytosol; protein binding;
GZMB	5	cytoplasm; nucleus; cytosol; apoptotic process; protein binding;
HMGCS1	5	cytoplasm; nucleus; response to drug; cytosol; plasma membrane;
SLC9A3R2	5	cytoplasm; nucleus; protein C-terminus binding; protein binding; plasma membrane;
BASP1	5	cytoplasm; protein domain specific binding; nucleus; protein binding; plasma membrane;
CRYAB	5	cytoplasm; nucleus; cytosol; protein binding; plasma membrane;
EGLN3	5	cytoplasm; nucleus; cytosol; apoptotic process; protein binding;
ADRB1	5	cytoplasm; nucleus; apoptotic process; protein binding; plasma membrane;
YAP1	5	cytoplasm; nucleus; hippo signaling cascade; cytosol; protein binding;
DAXX	5	cytoplasm; nucleus; cytosol; apoptotic process; protein binding;
ARRB1	5	cytoplasm; nucleus; cytosol; protein binding; plasma membrane;
CORO1A	5	cytoplasm; nucleus; protein C-terminus binding; protein binding; plasma membrane;
CDK5RAP2	5	cytoplasm; cytosol; protein binding; cell junction; calmodulin binding;
STRN3	5	cytoplasm; nucleus; protein binding; plasma membrane; calmodulin binding;
ADAM17	5	cytoplasm; response to lipopolysaccharide; response to drug; protein binding; plasma membrane;
MAGI2	5	cytoplasm; nucleus; tight junction; protein binding; plasma membrane;
XPO1	5	cytoplasm; protein domain specific binding; response to drug; cytosol; protein binding;
MALT1	5	cytoplasm; nucleus; cytosol; protein binding; plasma membrane;
PDCD4	5	cytoplasm; nucleus; cytosol; apoptotic process; protein binding;
AIP	5	cytoplasm; nucleus; cytosol; protein binding; plasma membrane;
PKD1	5	cytoplasm; protein domain specific binding; nucleus; basolateral plasma membrane; protein binding;
INPPL1	5	cytoplasm; response to drug; cytosol; protein binding; plasma membrane;
DNAJA3	5	cytoplasm; nucleus; cytosol; protein binding; cell junction;
APBB1	5	cytoplasm; nucleus; apoptotic process; protein binding; plasma membrane;
FLCN	5	cytoplasm; nucleus; protein binding; plasma membrane; cell-cell junction assembly;
PSMC3	5	cytoplasm; nucleus; cytosol; apoptotic process; protein binding;
MAPK1	5	cytoplasm; nucleus; cytosol; apoptotic process; protein binding;
ERBB2	5	nucleus; protein C-terminus binding; basolateral plasma membrane; protein binding; plasma membrane;
GJA1	5	gap junction; intercalated disc; apoptotic process; protein binding; plasma membrane;
ADORA2A	5	response to drug; apoptotic process; protein binding; negative regulation of vascular permeability; plasma membrane;
ANK3	5	intercalated disc; tight junction; basolateral plasma membrane; protein binding; plasma membrane;
CADM1	5	apoptotic process; protein C-terminus binding; basolateral plasma membrane; protein binding; plasma membrane;

Genes shared at least 2 KEGG pathways with TJP1 (count: 16)

Gene Symbol	Pathway Count	Pathway List
ATP6V1G1	2	Epithelial cell signaling in Helicobacter pylori infection; Vibrio cholerae infection;
ATP6V1C2	2	Epithelial cell signaling in Helicobacter pylori infection; Vibrio cholerae infection;
ATP6V0A2	2	Epithelial cell signaling in Helicobacter pylori infection; Vibrio cholerae infection;
ATP6V0C	2	Epithelial cell signaling in Helicobacter pylori infection; Vibrio cholerae infection;
ATP6V1F	2	Epithelial cell signaling in Helicobacter pylori infection; Vibrio cholerae infection;
JAM3	2	Epithelial cell signaling in Helicobacter pylori infection; Tight junction;
PLCG2	2	Epithelial cell signaling in Helicobacter pylori infection; Vibrio cholerae infection;
TCIRG1	2	Epithelial cell signaling in Helicobacter pylori infection; Vibrio cholerae infection;
CTNNA2	2	Adherens junction; Tight junction;
MAPK3	2	Adherens junction; Gap junction;
YES1	2	Adherens junction; Tight junction;
ACTN3	2	Adherens junction; Tight junction;
CTNNA3	2	Adherens junction; Tight junction;
MAPK1	2	Adherens junction; Gap junction;
ADCY9	2	Vibrio cholerae infection; Gap junction;
ADCY3	2	Vibrio cholerae infection; Gap junction;

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Region: chr15:29991571..30261068 View in gBrowse