ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	AKAP7
Symbol Alias	AKAP18, AKAP15
Approved Name	A kinase (PRKA) anchor protein 7
Location	6q22-q24
Position	chr6:131466424-131604675, +
External Links	HGNC: 377 Entrez Gene: 9465 Ensembl: ENSG00000118507 UCSC: uc011ebz.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043234	protein complex	Cellular Component		45
GO:0035556	intracellular signal transduction	Biological Process	TAS[10613906]	44
GO:0070382	exocytic vesicle	Cellular Component		3
GO:0051018	protein kinase A binding	Molecular Function	IDA[9545239]; TAS[10613906]	3
GO:0005829	cytosol	Cellular Component	IDA[10613906]	447
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[17244820]	910
GO:0003824	catalytic activity	Molecular Function		15
GO:0008022	protein C-terminus binding	Molecular Function		32
GO:0008104	protein localization	Biological Process	IC[9545239]	10
GO:0005886	plasma membrane	Cellular Component	TAS[10613906]	772
GO:0006811	ion transport	Biological Process	TAS[9545239]	25
GO:0016070	RNA metabolic process	Biological Process		46
GO:0016208	AMP binding	Molecular Function		3
GO:0008150	biological_process	Biological Process		106
GO:0010738	regulation of protein kinase A signaling cascade	Biological Process		2
GO:0016529	sarcoplasmic reticulum	Cellular Component		11
GO:0019901	protein kinase binding	Molecular Function		51
GO:0016324	apical plasma membrane	Cellular Component	IDA[10613906]	51
GO:0016328	lateral plasma membrane	Cellular Component	IDA[10613906]	8
GO:0032947	protein complex scaffold	Molecular Function		5
GO:0034237	protein kinase A regulatory subunit binding	Molecular Function		2
GO:0019904	protein domain specific binding	Molecular Function		40
GO:0030315	T-tubule	Cellular Component		12

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with AKAP7 (count: 27)

Gene Symbol	Pathway Count	Pathway List
CEP250	6	protein complex; cytosol; protein binding; protein C-terminus binding; protein localization; protein kinase binding;
GSK3B	6	intracellular signal transduction; cytosol; nucleus; protein binding; plasma membrane; protein kinase binding;
APC	6	cytosol; nucleus; protein binding; plasma membrane; protein kinase binding; lateral plasma membrane;
ARRB2	6	cytosol; nucleus; protein binding; plasma membrane; protein complex scaffold; protein domain specific binding;
TJP1	6	cytosol; nucleus; protein binding; protein C-terminus binding; plasma membrane; protein domain specific binding;
CAV3	6	protein binding; protein C-terminus binding; protein localization; plasma membrane; protein complex scaffold; T-tubule;
CORO1A	5	protein complex; nucleus; protein binding; protein C-terminus binding; plasma membrane;
ILK	5	protein complex; cytosol; protein binding; plasma membrane; protein kinase binding;
MALT1	5	protein complex; cytosol; nucleus; protein binding; plasma membrane;
PAK1	5	protein complex; cytosol; protein binding; plasma membrane; protein kinase binding;
RYR2	5	protein complex; protein binding; plasma membrane; sarcoplasmic reticulum; protein kinase A regulatory subunit binding;
PRKCB	5	intracellular signal transduction; cytosol; nucleus; protein binding; plasma membrane;
ROCK2	5	intracellular signal transduction; cytosol; nucleus; protein binding; plasma membrane;
SQSTM1	5	intracellular signal transduction; cytosol; protein binding; protein localization; protein kinase binding;
AIP	5	cytosol; nucleus; protein binding; plasma membrane; regulation of protein kinase A signaling cascade;
BAIAP2	5	cytosol; nucleus; protein binding; protein C-terminus binding; plasma membrane;
CLNS1A	5	cytosol; nucleus; protein binding; plasma membrane; RNA metabolic process;
CTNND1	5	cytosol; nucleus; protein binding; plasma membrane; protein domain specific binding;
HSPA8	5	cytosol; nucleus; protein binding; plasma membrane; RNA metabolic process;
NCK1	5	cytosol; nucleus; protein binding; plasma membrane; protein domain specific binding;
PRKAA1	5	cytosol; nucleus; protein binding; protein C-terminus binding; apical plasma membrane;
RPS3	5	cytosol; nucleus; protein binding; RNA metabolic process; protein kinase binding;
SNCA	5	cytosol; nucleus; protein binding; plasma membrane; protein domain specific binding;
STXBP3	5	cytosol; nucleus; protein binding; plasma membrane; apical plasma membrane;
THY1	5	cytosol; protein binding; plasma membrane; protein kinase binding; apical plasma membrane;
ERBB2	5	nucleus; protein binding; protein C-terminus binding; plasma membrane; apical plasma membrane;
SLC3A2	5	protein binding; catalytic activity; plasma membrane; ion transport; apical plasma membrane;

Genes shared at least 2 KEGG pathways with AKAP7 (count: 0)

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Region: chr6:131466424..131604675 View in gBrowse