ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SLC3A2
Previous Symbol	MDU1
Symbol Alias	4T2HC, 4F2, NACAE, CD98, CD98HC, 4F2HC
Approved Name	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Name Alias	###############################################################################################################################################################################################################################################################
Location	11q12-q22
Position	chr11:62623518-62656353, +
External Links	HGNC: 11026 Entrez Gene: 6520 Ensembl: ENSG00000168003 UCSC: uc001nwd.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003824	catalytic activity	Molecular Function		15
GO:0005515	protein binding	Molecular Function	IPI[10631289]	910
GO:0005432	calcium:sodium antiporter activity	Molecular Function	TAS[10673541]	1
GO:0005975	carbohydrate metabolic process	Biological Process		50
GO:0005886	plasma membrane	Cellular Component		772
GO:0042470	melanosome	Cellular Component		22
GO:0043169	cation binding	Molecular Function		4
GO:0016049	cell growth	Biological Process	NAS[3476959]	11
GO:0016324	apical plasma membrane	Cellular Component		51
GO:0060356	leucine import	Biological Process		1
GO:0050900	leukocyte migration	Biological Process		13
GO:0055085	transmembrane transport	Biological Process		82
GO:0006865	amino acid transport	Biological Process		5
GO:0007596	blood coagulation	Biological Process		83
GO:0006811	ion transport	Biological Process		25
GO:0006816	calcium ion transport	Biological Process	NAS[3036867]	32
GO:0015827	tryptophan transport	Biological Process		2
GO:0016021	integral to membrane	Cellular Component	NAS[3476959]	845
GO:0009986	cell surface	Cellular Component	IDA[12493773]	70
GO:0015175	neutral amino acid transmembrane transporter activity	Molecular Function		4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04974	Protein digestion and absorption	10	Protein is a dietary component essential for nutritional hom...... Protein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancreatic and small intestinal enzymes. The result of this proteolytic activity is a mixture of amino acids and small peptides. Amino acids (AAs) are transported into the enterocyte (intestinal epithelial cell) by a variety of AA transporters that are specific for cationic (basic) AA, neutral AA, and anionic (acidic) AA. Small peptides are absorbed into enterocytes by the PEPT1 transporter. Inside enterocytes peptides are hydrolyzed, and the resulting amino acids are released together with those absorbed by AA transporters into blood via multiple, basolateral, AA transporters. Hydrolysis-resistant peptides, however, are transported out of the cells by a basolateral peptide transporter that has not been identified molecularly. More...

Genes shared at least 5 GO terms with SLC3A2 (count: 9)

Gene Symbol	Pathway Count	Pathway List
SLC7A5	9	plasma membrane; apical plasma membrane; leukocyte migration; transmembrane transport; amino acid transport; blood coagulation; ion transport; integral to membrane; neutral amino acid transmembrane transporter activity;
SLC7A10	7	plasma membrane; leukocyte migration; transmembrane transport; amino acid transport; blood coagulation; ion transport; neutral amino acid transmembrane transporter activity;
AKAP7	5	catalytic activity; protein binding; plasma membrane; apical plasma membrane; ion transport;
JAM3	5	protein binding; plasma membrane; leukocyte migration; blood coagulation; integral to membrane;
SLC14A2	5	protein binding; plasma membrane; apical plasma membrane; transmembrane transport; integral to membrane;
STX4	5	protein binding; plasma membrane; blood coagulation; integral to membrane; cell surface;
SLC1A3	5	plasma membrane; transmembrane transport; ion transport; integral to membrane; cell surface;
SLC34A2	5	plasma membrane; apical plasma membrane; transmembrane transport; ion transport; integral to membrane;
SLC43A1	5	plasma membrane; transmembrane transport; amino acid transport; ion transport; neutral amino acid transmembrane transporter activity;

Genes shared at least 2 KEGG pathways with SLC3A2 (count: 0)

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Region: chr11:62623518..62656353 View in gBrowse