ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STX4
Previous Symbol	STX4A
Symbol Alias	p35-2
Approved Name	syntaxin 4
Previous Name	syntaxin 4A (placental)
Location	16p11.2
Position	chr16:31044319-31051489, +
External Links	HGNC: 11439 Entrez Gene: 6810 Ensembl: ENSG00000103496 UCSC: uc002eal.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	IPI[16189514]	910
GO:0005773	vacuole	Cellular Component	TAS[16339081]	2
GO:0005802	trans-Golgi network	Cellular Component		28
GO:0005829	cytosol	Cellular Component		447
GO:0000149	SNARE binding	Molecular Function		6
GO:0005484	SNAP receptor activity	Molecular Function		13
GO:0042581	specific granule	Cellular Component	IDA[18588921]	5
GO:0035749	myelin sheath adaxonal region	Cellular Component		1
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0043219	lateral loop	Cellular Component		1
GO:0016323	basolateral plasma membrane	Cellular Component	IDA[16339081]	29
GO:0016044	cellular membrane organization	Biological Process		24
GO:0031201	SNARE complex	Cellular Component	IDA[19546860]	13
GO:0030168	platelet activation	Biological Process		38
GO:0009986	cell surface	Cellular Component	IDA[15576373]	70
GO:0007596	blood coagulation	Biological Process		83
GO:0016021	integral to membrane	Cellular Component		845
GO:0016020	membrane	Cellular Component	TAS[7690687]	139
GO:0006836	neurotransmitter transport	Biological Process		5
GO:0005886	plasma membrane	Cellular Component		772
GO:0006892	post-Golgi vesicle-mediated transport	Biological Process		16
GO:0006886	intracellular protein transport	Biological Process		43

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04962	Vasopressin-regulated water reabsorption	6	In the kidney, the antidiuretic hormone vasopressin (AVP) is...... In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again. More...
hsa04130	SNARE interactions in vesicular transport	20

Genes shared at least 5 GO terms with STX4 (count: 31)

Gene Symbol	Pathway Count	Pathway List
STX3	8	protein binding; vacuole; SNAP receptor activity; specific granule; SNARE complex; integral to membrane; neurotransmitter transport; intracellular protein transport;
ARRB1	7	protein binding; cytosol; cellular membrane organization; platelet activation; blood coagulation; plasma membrane; post-Golgi vesicle-mediated transport;
SNAP25	7	protein binding; trans-Golgi network; SNARE binding; perinuclear region of cytoplasm; SNARE complex; membrane; plasma membrane;
STX1A	7	protein binding; SNARE binding; SNAP receptor activity; SNARE complex; integral to membrane; plasma membrane; intracellular protein transport;
STX6	7	protein binding; SNAP receptor activity; perinuclear region of cytoplasm; SNARE complex; integral to membrane; plasma membrane; intracellular protein transport;
STXBP3	7	protein binding; cytosol; specific granule; basolateral plasma membrane; platelet activation; blood coagulation; plasma membrane;
STX7	7	SNARE binding; SNAP receptor activity; perinuclear region of cytoplasm; SNARE complex; integral to membrane; post-Golgi vesicle-mediated transport; intracellular protein transport;
ARRB2	6	protein binding; cytosol; basolateral plasma membrane; platelet activation; blood coagulation; plasma membrane;
CLINT1	6	protein binding; cytosol; perinuclear region of cytoplasm; cellular membrane organization; membrane; post-Golgi vesicle-mediated transport;
HSPA8	6	protein binding; cytosol; cellular membrane organization; cell surface; plasma membrane; post-Golgi vesicle-mediated transport;
PIK3CG	6	protein binding; cytosol; platelet activation; blood coagulation; membrane; plasma membrane;
ACHE	5	protein binding; perinuclear region of cytoplasm; cell surface; membrane; plasma membrane;
ADRA2A	5	protein binding; basolateral plasma membrane; platelet activation; blood coagulation; plasma membrane;
BCAR1	5	protein binding; cytosol; platelet activation; blood coagulation; plasma membrane;
COPB1	5	protein binding; cytosol; cellular membrane organization; plasma membrane; intracellular protein transport;
EHD1	5	protein binding; perinuclear region of cytoplasm; blood coagulation; plasma membrane; intracellular protein transport;
ENPP1	5	protein binding; basolateral plasma membrane; cell surface; integral to membrane; plasma membrane;
ERBB2	5	protein binding; perinuclear region of cytoplasm; basolateral plasma membrane; integral to membrane; plasma membrane;
NAPA	5	protein binding; cytosol; cellular membrane organization; post-Golgi vesicle-mediated transport; intracellular protein transport;
PDE2A	5	protein binding; cytosol; perinuclear region of cytoplasm; blood coagulation; plasma membrane;
PIK3R1	5	protein binding; cytosol; platelet activation; blood coagulation; plasma membrane;
PLCG2	5	protein binding; cytosol; platelet activation; blood coagulation; plasma membrane;
PRKCB	5	protein binding; cytosol; platelet activation; blood coagulation; plasma membrane;
SLC3A2	5	protein binding; cell surface; blood coagulation; integral to membrane; plasma membrane;
SNAP23	5	protein binding; specific granule; cellular membrane organization; plasma membrane; post-Golgi vesicle-mediated transport;
STX16	5	protein binding; SNAP receptor activity; SNARE complex; integral to membrane; intracellular protein transport;
SYK	5	protein binding; cytosol; platelet activation; blood coagulation; plasma membrane;
TRPC6	5	protein binding; platelet activation; blood coagulation; integral to membrane; plasma membrane;
VAMP2	5	protein binding; cellular membrane organization; SNARE complex; plasma membrane; post-Golgi vesicle-mediated transport;
VEGFA	5	protein binding; platelet activation; cell surface; blood coagulation; membrane;
STX17	5	SNARE binding; SNAP receptor activity; SNARE complex; integral to membrane; intracellular protein transport;

Genes shared at least 2 KEGG pathways with STX4 (count: 1)

Gene Symbol	Pathway Count	Pathway List
VAMP2	2	Vasopressin-regulated water reabsorption; SNARE interactions in vesicular transport;

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Region: chr16:31044319..31051489 View in gBrowse