ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0019901
Name	protein kinase binding
Type	molecular function
No. of Genes in ADHDgene	59
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 59)

Literature-origin genes (count: 6)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
PTPRJ	protein tyrosine phosphatase, receptor type, J	11p11.2	1(0/1/0)	IPI[19332538]
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)	IPI[18348280]
PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	7q35-q36	1(0/0/1)	IDA[10698692]
ADRA2A	adrenoceptor alpha 2A	10q25.2	13(4/9/0)	IPI[15653687]
PARK2	parkin RBR E3 ubiquitin protein ligase	6q25.2-q27	1(1/0/0)	IPI
MAP2K3	mitogen-activated protein kinase kinase 3	17q11.2	1(0/1/0)	IPI[11279118]

Genes from other sources (count: 53)

Approved Symbol	Approved Name	Source	Evidence[PMID]
MAP3K5	mitogen-activated protein kinase kinase kinase 5	Mapped by LD-proxy; Mapped by significant region	IEA
LIPE	lipase, hormone-sensitive	Mapped by PBA pathway	IEA
PRKAG3	protein kinase, AMP-activated, gamma 3 non-catalytic subunit	Mapped by significant region	IDA[10698692]
CEP250	centrosomal protein 250kDa	Mapped by PBA pathway	IPI[9647649]
AXIN1	axin 1	Mapped by significant region	IBA; IDA[15526030]; ISS
PRC1	protein regulator of cytokinesis 1	Mapped by PBA pathway	IPI[17351640]
SOCS1	suppressor of cytokine signaling 1	Mapped by significant region	IPI[9727029]
LATS1	large tumor suppressor kinase 1	Mapped by PBA pathway	IPI[19927127]
MAVS	mitochondrial antiviral signaling protein	Mapped by CNV	IPI[16127453]
SREBF1	sterol regulatory element binding transcription factor 1	Mapped by significant region	IEA
GHR	growth hormone receptor	Mapped by CNV; Mapped by significant region	ISS
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	Mapped by significant region	IEA
STK11IP	serine/threonine kinase 11 interacting protein	Mapped by significant region	IPI[11741830]
PPME1	protein phosphatase methylesterase 1	Mapped by significant region; Mapped by PBA pathway	IEA
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	Mapped by significant region	ISS
CNPPD1	cyclin Pas1/PHO80 domain containing 1	Mapped by significant region	IEA
RPS3	ribosomal protein S3	Mapped by significant region	IPI[15950189]
PTPRK	protein tyrosine phosphatase, receptor type, K	Mapped by CNV; Mapped by significant region	IPI[15899872]
GATA6	GATA binding protein 6	Mapped by significant region	IPI
MAML1	mastermind-like 1 (Drosophila)	Mapped by CNV	IPI[15546612]
APC	adenomatous polyposis coli	Mapped by LD-proxy; Mapped by PBA pathway	IPI[8638126]
RNF138	ring finger protein 138, E3 ubiquitin protein ligase	Mapped by significant region	IPI[16714285]
PKD1	polycystic kidney disease 1 (autosomal dominant)	Mapped by significant region	IPI[17980165]
BCAR1	breast cancer anti-estrogen resistance 1	Mapped by significant region	IPI[10026197]
SYK	spleen tyrosine kinase	Mapped by significant region	IEA
SPDYC	speedy/RINGO cell cycle regulator family member C	Mapped by significant region	IPI[15611625]
LLGL1	lethal giant larvae homolog 1 (Drosophila)	Mapped by significant region	IDA[7542763]
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	Mapped by significant region	NAS[12110186]
CDK5RAP2	CDK5 regulatory subunit associated protein 2	Mapped by significant region	IPI[10721722]
NEK6	NIMA-related kinase 6	Mapped by significant region	IPI[19001501]
MAPT	microtubule-associated protein tau	Mapped by LD-proxy; Mapped by PBA pathway	IEA
CENPJ	centromere protein J	Mapped by PBA pathway	IPI
CABYR	calcium binding tyrosine-(Y)-phosphorylation regulated	Mapped by significant region	IEA
KIF11	kinesin family member 11	Mapped by PBA pathway	IPI[19001501]
BAD	BCL2-associated agonist of cell death	Mapped by significant region	IPI[17270021]
TPCN2	two pore segment channel 2	Mapped by CNV; Mapped by significant region	IPI
CCND3	cyclin D3	Mapped by CNV	IPI[8114739]
DNAJA3	DnaJ (Hsp40) homolog, subfamily A, member 3	Mapped by significant region	IPI[15601829]
RELA	v-rel avian reticuloendotheliosis viral oncogene homolog A	Mapped by significant region	IPI[15465828]
MS4A2	membrane-spanning 4-domains, subfamily A, member 2	Mapped by significant region; Mapped by PBA pathway	IEA
AKAP7	A kinase (PRKA) anchor protein 7	Mapped by significant region	IEA
PARN	poly(A)-specific ribonuclease	Mapped by significant region	IPI
SQSTM1	sequestosome 1	Mapped by CNV	IDA[8650207]
RPTOR	regulatory associated protein of MTOR, complex 1	Mapped by LD-proxy	IPI[18439900]
RAD9A	RAD9 homolog A (S. pombe)	Mapped by significant region	IPI[12628935]
PDPK1	3-phosphoinositide dependent protein kinase-1	Mapped by significant region	IEA
ILK	integrin-linked kinase	Mapped by CNV	IPI[19118217]
USP37	ubiquitin specific peptidase 37	Mapped by significant region	IPI
PLK1	polo-like kinase 1	Mapped by significant region	IPI
DAB2IP	DAB2 interacting protein	Mapped by significant region	IPI
CCND1	cyclin D1	Mapped by significant region	IPI[8114739]
THY1	Thy-1 cell surface antigen	Mapped by significant region	IEA
CDC25B	cell division cycle 25B	Mapped by CNV	IPI[15908796]