ADHDgene Database

Gene Report

Basic Info

Approved Symbol	LIPE
Symbol Alias	HSL
Approved Name	lipase, hormone-sensitive
Location	19q13.1-q13.2
Position	chr19:42905659-42931578, -
External Links	HGNC: 6621 Entrez Gene: 3991 Ensembl: ENSG00000079435 UCSC: uc002otr.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49
GO:0004091	carboxylesterase activity	Molecular Function		40

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0019433	triglyceride catabolic process	Biological Process		7
GO:0019901	protein kinase binding	Molecular Function		51
GO:0033878	hormone-sensitive lipase activity	Molecular Function		1
GO:0006468	protein phosphorylation	Biological Process	TAS[3420405]	53
GO:0006629	lipid metabolic process	Biological Process		51
GO:0008203	cholesterol metabolic process	Biological Process		16
GO:0016042	lipid catabolic process	Biological Process		32
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0046340	diacylglycerol catabolic process	Biological Process		1
GO:0004806	triglyceride lipase activity	Molecular Function		10
GO:0005901	caveola	Cellular Component		12
GO:0005829	cytosol	Cellular Component		447
GO:0005811	lipid particle	Cellular Component		6
GO:0005515	protein binding	Molecular Function	IPI[17026959]	910

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04910	Insulin signaling pathway	29	Insulin binding to its receptor results in the tyrosine phos...... Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR. More...

Genes shared at least 5 GO terms with LIPE (count: 8)

Gene Symbol	Pathway Count	Pathway List
LPL	7	lipase activity; triglyceride catabolic process; lipid metabolic process; small molecule metabolic process; triglyceride lipase activity; carboxylesterase activity; protein binding;
PNLIP	6	lipase activity; lipid metabolic process; lipid catabolic process; small molecule metabolic process; triglyceride lipase activity; carboxylesterase activity;
APOC2	5	lipase activity; lipid metabolic process; lipid catabolic process; small molecule metabolic process; carboxylesterase activity;
MGLL	5	lipase activity; triglyceride catabolic process; lipid metabolic process; small molecule metabolic process; carboxylesterase activity;
PLA2G6	5	lipase activity; lipid catabolic process; small molecule metabolic process; carboxylesterase activity; cytosol;
PNLIPRP2	5	lipase activity; lipid metabolic process; small molecule metabolic process; triglyceride lipase activity; carboxylesterase activity;
PNPLA3	5	lipase activity; triglyceride catabolic process; small molecule metabolic process; triglyceride lipase activity; carboxylesterase activity;
PPP1CA	5	triglyceride catabolic process; lipid metabolic process; small molecule metabolic process; cytosol; protein binding;

Genes shared at least 2 KEGG pathways with LIPE (count: 0)

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Region: chr19:42905659..42931578 View in gBrowse