ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LPL
Previous Symbol	LIPD
Approved Name	lipoprotein lipase
Location	8p22
Position	chr8:19759228-19824769, 1
External Links	HGNC: 6677 Entrez Gene: 4023 Ensembl: ENSG00000175445 UCSC: uc003wzk.4
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by Literature SNP; Mapped by PBA pathway

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lasky-Su J, 2008	1 flanking SNPs of this gene with P-value<1E-5.	Trend

Gene related SNPs (count: 7)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs7816032	chr8:19786891(Fwd)	intron_variant	1(0/0/1)

LD-proxies (count: 6)

rs_ID	Location	Functional Annotation
rs1534649	chr8:19799641(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant
rs4466415	chr8:19776981(Fwd)	intron_variant
rs28834434	chr8:19774890(Fwd)	intron_variant
rs3779787	chr8:19797916(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant
rs3779788	chr8:19803093(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant
rs10104051	chr8:19802402(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0009986	cell surface	cellular component	IEA	75
GO:0010744	positive regulation of macrophage derived foam cell differentiation	biological process	IC[12573449]	5
GO:0004806	triglyceride lipase activity	molecular function	IDA[182536]; ISS[10727238]	10
GO:0034371	chylomicron remodeling	biological process	IC[3973011]	3
GO:0034361	very-low-density lipoprotein particle	cellular component	IEA	6
GO:0042627	chylomicron	cellular component	IEA	5
GO:0006644	phospholipid metabolic process	biological process	ISS[10727238]	61
GO:0010890	positive regulation of sequestering of triglyceride	biological process	IMP[12573449]	2
GO:0042157	lipoprotein metabolic process	biological process	TAS	11
GO:0070328	triglyceride homeostasis	biological process	IGI[17018885]	7
GO:0006641	triglyceride metabolic process	biological process	ISS[10727238]	8
GO:0034185	apolipoprotein binding	molecular function	IPI[15178420]	5
GO:0034372	very-low-density lipoprotein particle remodeling	biological process	IDA[3973011]; ISS	3
GO:0005576	extracellular region	cellular component	TAS	267
GO:0031012	extracellular matrix	cellular component	IEA	29
GO:0004620	phospholipase activity	molecular function	ISS[10727238]	4
GO:0031225	anchored to membrane	cellular component	IEA	33
GO:0042493	response to drug	biological process	IEA	73
GO:0019433	triglyceride catabolic process	biological process	IDA[182536]; ISS	7
GO:0005886	plasma membrane	cellular component	IEA	839
GO:0019432	triglyceride biosynthetic process	biological process	IEA	12
GO:0006633	fatty acid biosynthetic process	biological process	IC[3973011]; IDA[182536]; ISS	16
GO:0008201	heparin binding	molecular function	IDA[12573449]	28
GO:0006629	lipid metabolic process	biological process	TAS	51
GO:0005615	extracellular space	cellular component	IDA[12573449]	133
GO:0017129	triglyceride binding	molecular function	IEA	1
GO:0005102	receptor binding	molecular function	IPI[10085125]	64
GO:0005515	protein binding	molecular function	IPI	1015
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0010886	positive regulation of cholesterol storage	biological process	IMP[12573449]	4
GO:0004465	lipoprotein lipase activity	molecular function	IDA[3973011]; ISS[10727238]	3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa05010	Alzheimer's disease	6
hsa03320	PPAR signaling pathway	13
hsa00561	Glycerolipid metabolism	15

Genes shared at least 5 GO terms with LPL (count: 32)

Gene Symbol	Pathway Count	Pathway List
APOA5	11	very-low-density lipoprotein particle; chylomicron; lipoprotein metabolic process; triglyceride homeostasis; triglyceride metabolic process; extracellular region; triglyceride catabolic process; heparin binding; extracellular space; protein binding; small molecule metabolic process;
APOC3	11	very-low-density lipoprotein particle; chylomicron; lipoprotein metabolic process; triglyceride homeostasis; triglyceride metabolic process; extracellular region; response to drug; triglyceride catabolic process; lipid metabolic process; extracellular space; small molecule metabolic process;
APOA4	10	cell surface; chylomicron remodeling; very-low-density lipoprotein particle; chylomicron; lipoprotein metabolic process; very-low-density lipoprotein particle remodeling; extracellular region; lipid metabolic process; extracellular space; small molecule metabolic process;
APOC2	10	chylomicron remodeling; very-low-density lipoprotein particle; chylomicron; lipoprotein metabolic process; triglyceride homeostasis; very-low-density lipoprotein particle remodeling; extracellular region; lipid metabolic process; extracellular space; small molecule metabolic process;
APOA1	10	very-low-density lipoprotein particle; lipoprotein metabolic process; triglyceride homeostasis; extracellular region; response to drug; plasma membrane; lipid metabolic process; extracellular space; protein binding; small molecule metabolic process;
ACHE	8	cell surface; phospholipid metabolic process; extracellular region; anchored to membrane; plasma membrane; extracellular space; protein binding; small molecule metabolic process;
SCARB1	8	cell surface; lipoprotein metabolic process; triglyceride homeostasis; apolipoprotein binding; plasma membrane; lipid metabolic process; small molecule metabolic process; positive regulation of cholesterol storage;
PNLIPRP2	7	triglyceride lipase activity; triglyceride metabolic process; extracellular region; phospholipase activity; lipid metabolic process; extracellular space; small molecule metabolic process;
PLA2G5	6	cell surface; phospholipid metabolic process; extracellular region; plasma membrane; heparin binding; small molecule metabolic process;
CTSG	6	cell surface; extracellular region; extracellular matrix; plasma membrane; heparin binding; extracellular space;
FGF10	6	cell surface; extracellular region; extracellular matrix; plasma membrane; heparin binding; extracellular space;
LIPG	6	triglyceride lipase activity; phospholipase activity; heparin binding; lipid metabolic process; extracellular space; lipoprotein lipase activity;
PLA2G1B	6	phospholipid metabolic process; extracellular region; fatty acid biosynthetic process; extracellular space; receptor binding; small molecule metabolic process;
MGLL	6	phospholipid metabolic process; triglyceride catabolic process; plasma membrane; fatty acid biosynthetic process; lipid metabolic process; small molecule metabolic process;
ABCA1	6	lipoprotein metabolic process; apolipoprotein binding; plasma membrane; lipid metabolic process; protein binding; small molecule metabolic process;
MIF	5	cell surface; extracellular region; extracellular space; receptor binding; protein binding;
ENPP1	5	cell surface; plasma membrane; extracellular space; protein binding; small molecule metabolic process;
VEGFA	5	cell surface; extracellular region; heparin binding; extracellular space; protein binding;
GHR	5	cell surface; extracellular region; plasma membrane; extracellular space; protein binding;
MSLN	5	cell surface; anchored to membrane; plasma membrane; extracellular space; protein binding;
PLA2G10	5	positive regulation of macrophage derived foam cell differentiation; phospholipid metabolic process; extracellular region; phospholipase activity; small molecule metabolic process;
PLA2G2A	5	positive regulation of macrophage derived foam cell differentiation; phospholipid metabolic process; extracellular region; extracellular space; small molecule metabolic process;
LIPE	5	triglyceride lipase activity; triglyceride catabolic process; lipid metabolic process; protein binding; small molecule metabolic process;
PNPLA3	5	triglyceride lipase activity; phospholipid metabolic process; triglyceride catabolic process; triglyceride biosynthetic process; small molecule metabolic process;
PLA2G3	5	phospholipid metabolic process; extracellular region; plasma membrane; extracellular space; small molecule metabolic process;
SNCA	5	phospholipid metabolic process; extracellular region; response to drug; plasma membrane; protein binding;
INPPL1	5	phospholipid metabolic process; response to drug; plasma membrane; protein binding; small molecule metabolic process;
FN1	5	extracellular region; extracellular matrix; heparin binding; extracellular space; protein binding;
VEGFB	5	extracellular region; response to drug; heparin binding; extracellular space; protein binding;
SERPINC1	5	extracellular region; plasma membrane; heparin binding; extracellular space; protein binding;
CTGF	5	extracellular region; plasma membrane; heparin binding; extracellular space; small molecule metabolic process;
OGN	5	extracellular region; extracellular matrix; extracellular space; protein binding; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with LPL (count: 0)

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Region: chr8:19759228..19824769 View in gBrowse