ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CTSG
Symbol Alias	CG
Approved Name	cathepsin G
Location	14q12
Position	chr14:25042724-25045466, -
External Links	HGNC: 2532 Entrez Gene: 1511 Ensembl: ENSG00000100448 UCSC: uc001wpq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005615	extracellular space	Cellular Component		126
GO:0005576	extracellular region	Cellular Component		240
GO:0006508	proteolysis	Biological Process	IDA[11907569]	102
GO:0005886	plasma membrane	Cellular Component	IDA[1861080]	772
GO:0008201	heparin binding	Molecular Function	IDA[11907569]	26
GO:0006955	immune response	Biological Process	TAS[2569462]	45
GO:0009986	cell surface	Cellular Component		70
GO:0008233	peptidase activity	Molecular Function	IDA[11907569]	15
GO:0004252	serine-type endopeptidase activity	Molecular Function	IDA[8194606]	29
GO:0070946	neutrophil mediated killing of gram-positive bacterium	Biological Process		1
GO:0022617	extracellular matrix disassembly	Biological Process		14
GO:0030141	secretory granule	Cellular Component	IDA[11907569]	17
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0031012	extracellular matrix	Cellular Component		28
GO:0032496	response to lipopolysaccharide	Biological Process		22
GO:0044130	negative regulation of growth of symbiont in host	Biological Process		4
GO:0050778	positive regulation of immune response	Biological Process		2
GO:0050832	defense response to fungus	Biological Process		3

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04614	Renin-angiotensin system	4
hsa05146	Amoebiasis	19	Entamoeba histolytica, an extracellular protozoan parasite i...... Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response. More...
hsa04142	Lysosome	19	Lysosomes are membrane-delimited organelles in animal cells ...... Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy. More...
hsa05322	Systemic lupus erythematosus	19	Systemic lupus erythematosus (SLE) is a prototypic autoimmun...... Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases. More...

Genes shared at least 5 GO terms with CTSG (count: 16)

Gene Symbol	Pathway Count	Pathway List
FURIN	8	extracellular space; proteolysis; plasma membrane; cell surface; peptidase activity; serine-type endopeptidase activity; extracellular matrix disassembly; extracellular matrix organization;
FGF10	7	extracellular space; extracellular region; plasma membrane; heparin binding; cell surface; extracellular matrix; response to lipopolysaccharide;
CTRB1	6	extracellular space; extracellular region; proteolysis; serine-type endopeptidase activity; extracellular matrix disassembly; extracellular matrix organization;
CTRB2	6	extracellular space; extracellular region; proteolysis; serine-type endopeptidase activity; extracellular matrix disassembly; extracellular matrix organization;
IHH	6	extracellular space; extracellular region; proteolysis; plasma membrane; peptidase activity; extracellular matrix;
LPL	6	extracellular space; extracellular region; plasma membrane; heparin binding; cell surface; extracellular matrix;
MMP8	6	extracellular space; extracellular region; proteolysis; serine-type endopeptidase activity; extracellular matrix disassembly; extracellular matrix organization;
CMA1	6	extracellular region; proteolysis; serine-type endopeptidase activity; extracellular matrix disassembly; extracellular matrix organization; extracellular matrix;
F7	5	extracellular space; extracellular region; proteolysis; plasma membrane; serine-type endopeptidase activity;
MMP10	5	extracellular space; extracellular region; proteolysis; extracellular matrix disassembly; extracellular matrix organization;
MMP13	5	extracellular space; extracellular region; proteolysis; extracellular matrix disassembly; extracellular matrix organization;
MMP3	5	extracellular space; extracellular region; proteolysis; extracellular matrix disassembly; extracellular matrix organization;
MMP7	5	extracellular space; extracellular region; proteolysis; extracellular matrix disassembly; extracellular matrix organization;
PRSS8	5	extracellular space; extracellular region; proteolysis; plasma membrane; serine-type endopeptidase activity;
VEGFA	5	extracellular space; extracellular region; heparin binding; cell surface; secretory granule;
MMP16	5	proteolysis; plasma membrane; cell surface; extracellular matrix disassembly; extracellular matrix organization;

Genes shared at least 2 KEGG pathways with CTSG (count: 4)

Gene Symbol	Pathway Count	Pathway List
GRIN2A	2	Neuroactive ligand-receptor interaction; Systemic lupus erythematosus;
GRIN2B	2	Neuroactive ligand-receptor interaction; Systemic lupus erythematosus;
ACTN3	2	Amoebiasis; Systemic lupus erythematosus;
C9	2	Amoebiasis; Systemic lupus erythematosus;

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Region: chr14:25042724..25045466 View in gBrowse