Gene Report
Basic Info
Approved Symbol |
CTSG
|
Symbol Alias |
CG |
Approved Name |
cathepsin G |
Location |
14q12 |
Position |
chr14:25042724-25045466, - |
External Links |
HGNC: 2532
Entrez Gene: 1511
Ensembl: ENSG00000100448
UCSC: uc001wpq.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 18)
Gene related KEGG pathways (count: 5)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04080 |
Neuroactive ligand-receptor interaction |
93 |
|
hsa04614 |
Renin-angiotensin system |
4 |
|
hsa05146 |
Amoebiasis |
19 |
Entamoeba histolytica, an extracellular protozoan parasite i......
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
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|
hsa04142 |
Lysosome |
19 |
Lysosomes are membrane-delimited organelles in animal cells ......
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
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|
hsa05322 |
Systemic lupus erythematosus |
19 |
Systemic lupus erythematosus (SLE) is a prototypic autoimmun......
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.
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|
Genes shared at least 5 GO terms with CTSG (count: 16)
Genes shared at least 2 KEGG pathways with CTSG (count: 4)
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