ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MMP8
Previous Symbol	CLG1
Approved Name	matrix metallopeptidase 8 (neutrophil collagenase)
Previous Name	matrix metalloproteinase 8 (neutrophil collagenase)
Location	11q21-q22
Position	chr11:102582526-102597781, -
External Links	HGNC: 7175 Entrez Gene: 4317 Ensembl: ENSG00000118113 UCSC: uc001phe.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0005576	extracellular region	Cellular Component		240
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0004252	serine-type endopeptidase activity	Molecular Function	IDA[2164002]	29
GO:0005509	calcium ion binding	Molecular Function		124
GO:0008270	zinc ion binding	Molecular Function	TAS[2164002]	323
GO:0022617	extracellular matrix disassembly	Biological Process		14
GO:0005615	extracellular space	Cellular Component	IDA[2164002]	126
GO:0006508	proteolysis	Biological Process	IDA[2164002]	102
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0030574	collagen catabolic process	Biological Process		10

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MMP8 (count: 20)

Gene Symbol	Pathway Count	Pathway List
MMP10	10	metalloendopeptidase activity; extracellular region; proteinaceous extracellular matrix; calcium ion binding; zinc ion binding; extracellular matrix disassembly; extracellular space; proteolysis; extracellular matrix organization; collagen catabolic process;
MMP13	10	metalloendopeptidase activity; extracellular region; proteinaceous extracellular matrix; calcium ion binding; zinc ion binding; extracellular matrix disassembly; extracellular space; proteolysis; extracellular matrix organization; collagen catabolic process;
MMP3	10	metalloendopeptidase activity; extracellular region; proteinaceous extracellular matrix; calcium ion binding; zinc ion binding; extracellular matrix disassembly; extracellular space; proteolysis; extracellular matrix organization; collagen catabolic process;
MMP1	9	metalloendopeptidase activity; extracellular region; proteinaceous extracellular matrix; calcium ion binding; zinc ion binding; extracellular matrix disassembly; proteolysis; extracellular matrix organization; collagen catabolic process;
MMP11	9	metalloendopeptidase activity; extracellular region; proteinaceous extracellular matrix; calcium ion binding; zinc ion binding; extracellular matrix disassembly; proteolysis; extracellular matrix organization; collagen catabolic process;
MMP7	9	metalloendopeptidase activity; extracellular region; proteinaceous extracellular matrix; zinc ion binding; extracellular matrix disassembly; extracellular space; proteolysis; extracellular matrix organization; collagen catabolic process;
MMP16	8	metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding; zinc ion binding; extracellular matrix disassembly; proteolysis; extracellular matrix organization; collagen catabolic process;
ADAMTS2	7	metalloendopeptidase activity; extracellular region; proteinaceous extracellular matrix; zinc ion binding; proteolysis; extracellular matrix organization; collagen catabolic process;
MMP20	6	metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding; zinc ion binding; extracellular space; proteolysis;
MMP27	6	metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding; zinc ion binding; proteolysis; collagen catabolic process;
TLL1	6	metalloendopeptidase activity; extracellular region; calcium ion binding; zinc ion binding; proteolysis; extracellular matrix organization;
CTRB1	6	extracellular region; serine-type endopeptidase activity; extracellular matrix disassembly; extracellular space; proteolysis; extracellular matrix organization;
CTRB2	6	extracellular region; serine-type endopeptidase activity; extracellular matrix disassembly; extracellular space; proteolysis; extracellular matrix organization;
CTSG	6	extracellular region; serine-type endopeptidase activity; extracellular matrix disassembly; extracellular space; proteolysis; extracellular matrix organization;
MMP12	5	metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding; zinc ion binding; proteolysis;
MMP24	5	metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding; zinc ion binding; proteolysis;
TLL2	5	metalloendopeptidase activity; extracellular region; calcium ion binding; zinc ion binding; proteolysis;
CMA1	5	extracellular region; serine-type endopeptidase activity; extracellular matrix disassembly; proteolysis; extracellular matrix organization;
F7	5	extracellular region; serine-type endopeptidase activity; calcium ion binding; extracellular space; proteolysis;
FURIN	5	serine-type endopeptidase activity; extracellular matrix disassembly; extracellular space; proteolysis; extracellular matrix organization;

Genes shared at least 2 KEGG pathways with MMP8 (count: 0)

View in gBrowse

Region: chr11:102582526..102597781 View in gBrowse