ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MMP7
Previous Symbol	MPSL1
Symbol Alias	PUMP-1
Approved Name	matrix metallopeptidase 7 (matrilysin, uterine)
Previous Name	"matrix metalloproteinase 7 (matrilysin, uterine)"
Location	11q21-q22
Position	chr11:102391239-102401484, -1
External Links	HGNC: 7174 Entrez Gene: 4316 Ensembl: ENSG00000137673 UCSC: uc001phb.3
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2509689	chr11:102368719(Fwd)	intron_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030198	extracellular matrix organization	biological process	TAS	32
GO:0042493	response to drug	biological process	IEA	73
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	51
GO:0005615	extracellular space	cellular component	TAS[1497627]	133
GO:0050829	defense response to Gram-negative bacterium	biological process	IEA	7
GO:0006508	proteolysis	biological process	IEA	123
GO:0030574	collagen catabolic process	biological process	IEA	10
GO:0002779	antibacterial peptide secretion	biological process	IEA	1
GO:0042127	regulation of cell proliferation	biological process	IEA	22
GO:0005576	extracellular region	cellular component	TAS	267
GO:0004222	metalloendopeptidase activity	molecular function	IEA	36
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0022617	extracellular matrix disassembly	biological process	TAS	16
GO:0050830	defense response to Gram-positive bacterium	biological process	IEA	6

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04310	Wnt signaling pathway	25

Genes shared at least 5 GO terms with MMP7 (count: 16)

Gene Symbol	Pathway Count	Pathway List
MMP13	9	extracellular matrix organization; proteinaceous extracellular matrix; extracellular space; proteolysis; collagen catabolic process; extracellular region; metalloendopeptidase activity; zinc ion binding; extracellular matrix disassembly;
MMP10	9	extracellular matrix organization; proteinaceous extracellular matrix; extracellular space; proteolysis; collagen catabolic process; extracellular region; metalloendopeptidase activity; zinc ion binding; extracellular matrix disassembly;
MMP8	9	extracellular matrix organization; proteinaceous extracellular matrix; extracellular space; proteolysis; collagen catabolic process; extracellular region; metalloendopeptidase activity; zinc ion binding; extracellular matrix disassembly;
MMP3	9	extracellular matrix organization; proteinaceous extracellular matrix; extracellular space; proteolysis; collagen catabolic process; extracellular region; metalloendopeptidase activity; zinc ion binding; extracellular matrix disassembly;
MMP11	8	extracellular matrix organization; proteinaceous extracellular matrix; proteolysis; collagen catabolic process; extracellular region; metalloendopeptidase activity; zinc ion binding; extracellular matrix disassembly;
MMP1	8	extracellular matrix organization; proteinaceous extracellular matrix; proteolysis; collagen catabolic process; extracellular region; metalloendopeptidase activity; zinc ion binding; extracellular matrix disassembly;
ADAMTS2	7	extracellular matrix organization; proteinaceous extracellular matrix; proteolysis; collagen catabolic process; extracellular region; metalloendopeptidase activity; zinc ion binding;
MMP16	7	extracellular matrix organization; proteinaceous extracellular matrix; proteolysis; collagen catabolic process; metalloendopeptidase activity; zinc ion binding; extracellular matrix disassembly;
CTSG	5	extracellular matrix organization; extracellular space; proteolysis; extracellular region; extracellular matrix disassembly;
TLL1	5	extracellular matrix organization; proteolysis; extracellular region; metalloendopeptidase activity; zinc ion binding;
CTRB1	5	extracellular matrix organization; extracellular space; proteolysis; extracellular region; extracellular matrix disassembly;
TPSAB1	5	extracellular matrix organization; extracellular space; proteolysis; extracellular region; extracellular matrix disassembly;
CTRB2	5	extracellular matrix organization; extracellular space; proteolysis; extracellular region; extracellular matrix disassembly;
IL6	5	response to drug; extracellular space; defense response to Gram-negative bacterium; extracellular region; defense response to Gram-positive bacterium;
MMP20	5	proteinaceous extracellular matrix; extracellular space; proteolysis; metalloendopeptidase activity; zinc ion binding;
MMP27	5	proteinaceous extracellular matrix; proteolysis; collagen catabolic process; metalloendopeptidase activity; zinc ion binding;

Genes shared at least 2 KEGG pathways with MMP7 (count: 0)

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Region: chr11:102391239..102401484 View in gBrowse