ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TLL1
Approved Name	tolloid-like 1
Location	4q32-q33
Position	chr4:166794410-167025047, +
External Links	HGNC: 11843 Entrez Gene: 7092 Ensembl: ENSG00000038295 UCSC: uc003irh.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs17689952	Chr4:166939154(Fwd)	NMD_transcript_variant; intron_variant	2(0/2/0)

rs_ID	Location	Functional Annotation
rs17633333	Chr4:166926573(Fwd)	NMD_transcript_variant; intron_variant
rs17689892	Chr4:166927050(Fwd)	NMD_transcript_variant; intron_variant
rs1393857	Chr4:166933791(Fwd)	NMD_transcript_variant; intron_variant
rs17689964	Chr4:166946775(Fwd)	NMD_transcript_variant; intron_variant
rs17633422	Chr4:166948998(Fwd)	NMD_transcript_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0008270	zinc ion binding	Molecular Function		323
GO:0030154	cell differentiation	Biological Process		51
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0001501	skeletal system development	Biological Process	TAS[8661043]	16
GO:0005518	collagen binding	Molecular Function		8
GO:0005509	calcium ion binding	Molecular Function		124
GO:0006508	proteolysis	Biological Process		102
GO:0005576	extracellular region	Cellular Component		240

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TLL1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
MMP1	6	extracellular matrix organization; zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteolysis; extracellular region;
MMP10	6	extracellular matrix organization; zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteolysis; extracellular region;
MMP11	6	extracellular matrix organization; zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteolysis; extracellular region;
MMP13	6	extracellular matrix organization; zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteolysis; extracellular region;
MMP3	6	extracellular matrix organization; zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteolysis; extracellular region;
MMP8	6	extracellular matrix organization; zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteolysis; extracellular region;
TLL2	6	zinc ion binding; cell differentiation; metalloendopeptidase activity; calcium ion binding; proteolysis; extracellular region;
ADAMTS2	5	extracellular matrix organization; zinc ion binding; metalloendopeptidase activity; proteolysis; extracellular region;
MMP16	5	extracellular matrix organization; zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteolysis;
MMP7	5	extracellular matrix organization; zinc ion binding; metalloendopeptidase activity; proteolysis; extracellular region;

Genes shared at least 2 KEGG pathways with TLL1 (count: 0)

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Region: chr4:166794410..167025047 View in gBrowse