ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0006508
Name proteolysis
Type biological process
No. of Genes in ADHDgene  123
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 123)

Literature-origin genes (count: 8)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
TLL2 tolloid-like 2 10q23-q24 1(0/0/1) IEA
NLN neurolysin (metallopeptidase M3 family) 5q12.3 1(1/0/0) IEA
MMP7 matrix metallopeptidase 7 (matrilysin, uterine) 11q21-q22 1(0/0/1) IEA
QPCTL glutaminyl-peptide cyclotransferase-like 19q13.32 1(0/1/0) IEA
MMP24 matrix metallopeptidase 24 (membrane-inserted) 20q11.2 1(0/0/1) IEA
DPP6 dipeptidyl-peptidase 6 7q36.2 1(1/0/0) IEA
FURIN furin (paired basic amino acid cleaving enzyme) 15q26.1 1(0/0/1) TAS
AGBL1 ATP/GTP binding protein-like 1 15q25.3 1(0/0/1) IEA

Genes from other sources Help (count: 115)

Approved Symbol Approved Name Source Evidence[PMID]
ADAM7 ADAM metallopeptidase domain 7 Mapped by LD-proxy IEA
MMP1 matrix metallopeptidase 1 (interstitial collagenase) Mapped by significant region IEA
TPSG1 tryptase gamma 1 Mapped by significant region IEA
TPP1 tripeptidyl peptidase I Mapped by CNV IMP[10965052]
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 Mapped by LD-proxy IEA
DPP3 dipeptidyl-peptidase 3 Mapped by significant region IEA
PYDC1 PYD (pyrin domain) containing 1 Mapped by CNV IEA
CAPN5 calpain 5 Mapped by significant region IEA
UBE3A ubiquitin protein ligase E3A Mapped by CNV; Mapped by significant region TAS[8221889]
PRSS8 protease, serine, 8 Mapped by CNV IEA
BACE1 beta-site APP-cleaving enzyme 1 Mapped by significant region IDA[10531052]
AGBL2 ATP/GTP binding protein-like 2 Mapped by LD-proxy IEA
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 Mapped by significant region IEA
MMP12 matrix metallopeptidase 12 (macrophage elastase) Mapped by significant region IEA
CMA1 chymase 1, mast cell Mapped by significant region IEA
CTRB1 chymotrypsinogen B1 Mapped by significant region NAS
MEP1B meprin A, beta Mapped by significant region IEA
PRSS29P protease, serine, 29, pseudogene Mapped by significant region IEA
PRSS53 protease, serine, 53 Mapped by CNV IEA
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 Mapped by CNV; Mapped by significant region IEA
PRCP prolylcarboxypeptidase (angiotensinase C) Mapped by significant region IEA
PCSK7 proprotein convertase subtilisin/kexin type 7 Mapped by significant region IEA
TASP1 taspase, threonine aspartase, 1 Mapped by CNV IEA
TMPRSS11A transmembrane protease, serine 11A Mapped by significant region IEA
LONRF2 LON peptidase N-terminal domain and ring finger 2 Mapped by CNV IEA
OTUD7A OTU deubiquitinase 7A Mapped by CNV; Mapped by significant region IEA
BLMH bleomycin hydrolase Mapped by LD-proxy; Mapped by CNV IEA
CTSG cathepsin G Mapped by significant region IDA[11907569]
CTSC cathepsin C Mapped by significant region IDA[8811434]
FOLH1B folate hydrolase 1B Mapped by significant region IEA
PAPPA pregnancy-associated plasma protein A, pappalysin 1 Mapped by significant region IEA
MMP11 matrix metallopeptidase 11 (stromelysin 3) Mapped by CNV IEA
MBTPS1 membrane-bound transcription factor peptidase, site 1 Mapped by CNV; Mapped by significant region IBA
CASP1 caspase 1, apoptosis-related cysteine peptidase Mapped by significant region IDA[12888622]
DNPEP aspartyl aminopeptidase Mapped by significant region IEA
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 Mapped by Literature SNP; Mapped by CNV IEA
TRHDE thyrotropin-releasing hormone degrading enzyme Mapped by LD-proxy IEA
PRSS21 protease, serine, 21 (testisin) Mapped by significant region IEA
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 Mapped by CNV IEA
PGA5 pepsinogen 5, group I (pepsinogen A) Mapped by significant region IEA
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) Mapped by LD-proxy TAS[8632014]
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) Mapped by significant region IEA
MMP16 matrix metallopeptidase 16 (membrane-inserted) Mapped by CNV IEA
RHBDF1 rhomboid 5 homolog 1 (Drosophila) Mapped by significant region IEA
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 Mapped by significant region IDA[18223652]
UQCRC2 ubiquinol-cytochrome c reductase core protein II Mapped by CNV; Mapped by significant region IEA
ASTL astacin-like metallo-endopeptidase (M12 family) Mapped by LD-proxy IDA[15087446]
TMPRSS11B transmembrane protease, serine 11B Mapped by significant region IEA
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) Mapped by significant region IEA
CPVL carboxypeptidase, vitellogenic-like Mapped by CNV IEA
CTSV cathepsin V Mapped by significant region IEA
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) Mapped by significant region NAS
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 Mapped by significant region IEA
CASP16 caspase 16, apoptosis-related cysteine peptidase (putative) Mapped by significant region IEA
ST14 suppression of tumorigenicity 14 (colon carcinoma) Mapped by significant region IDA[19911255]
FBXW2 F-box and WD repeat domain containing 2 Mapped by significant region TAS[10531035]
F7 coagulation factor VII (serum prothrombin conversion accelerator) Mapped by CNV TAS
CARD17 caspase recruitment domain family, member 17 Mapped by significant region IEA
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 Mapped by significant region NAS[10085079]
MMP25 matrix metallopeptidase 25 Mapped by significant region NAS[10706098]
MMP20 matrix metallopeptidase 20 Mapped by significant region IEA
CASP12 caspase 12 (gene/pseudogene) Mapped by significant region IEA
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 Mapped by significant region IEA
RCE1 Ras converting CAAX endopeptidase 1 Mapped by significant region TAS[10085068]
TMPRSS4 transmembrane protease, serine 4 Mapped by significant region NAS[10825129]
ADAM8 ADAM metallopeptidase domain 8 Mapped by LD-proxy; Mapped by CNV IEA
PRSS41 protease, serine, 41 Mapped by significant region IEA
PRSS33 protease, serine, 33 Mapped by significant region IEA
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 Mapped by significant region IEA
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) Mapped by significant region IEA
PCSK6 proprotein convertase subtilisin/kexin type 6 Mapped by CNV IEA
MMP10 matrix metallopeptidase 10 (stromelysin 2) Mapped by significant region IEA
THOP1 thimet oligopeptidase 1 Mapped by LD-proxy IEA
TPSAB1 tryptase alpha/beta 1 Mapped by significant region IEA
CAPN15 calpain 15 Mapped by significant region IEA
CAPN1 calpain 1, (mu/I) large subunit Mapped by significant region IEA
PYCARD PYD and CARD domain containing Mapped by CNV IEA
CPD carboxypeptidase D Mapped by CNV IEA
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) Mapped by CNV IEA
PRSS27 protease, serine 27 Mapped by significant region IEA
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) Mapped by significant region IEA
ADAM33 ADAM metallopeptidase domain 33 Mapped by CNV NAS[11814695]
PRSS36 protease, serine, 36 Mapped by CNV IEA
PGA4 pepsinogen 4, group I (pepsinogen A) Mapped by significant region IEA
SHFM1 split hand/foot malformation (ectrodactyly) type 1 Mapped by LD-proxy IDA[10373512]
MMP27 matrix metallopeptidase 27 Mapped by significant region IEA
TPSD1 tryptase delta 1 Mapped by significant region IEA
F10 coagulation factor X Mapped by CNV TAS
SEC11C SEC11 homolog C (S. cerevisiae) Mapped by significant region IEA
CTSF cathepsin F Mapped by significant region IEA
MMP8 matrix metallopeptidase 8 (neutrophil collagenase) Mapped by significant region IDA[2164002]
TMPRSS11D transmembrane protease, serine 11D Mapped by significant region IEA
TMPRSS11E transmembrane protease, serine 11E Mapped by significant region ISS
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 Mapped by significant region IEA
IHH indian hedgehog Mapped by significant region IEA
TMPRSS11F transmembrane protease, serine 11F Mapped by significant region IEA
PRSS23 protease, serine, 23 Mapped by significant region IEA
CASP4 caspase 4, apoptosis-related cysteine peptidase Mapped by significant region IEA
CTSW cathepsin W Mapped by significant region IEA
CTRB2 chymotrypsinogen B2 Mapped by significant region IEA
TMPRSS5 transmembrane protease, serine 5 Mapped by significant region IMP[17918732]
TMPRSS13 transmembrane protease, serine 13 Mapped by significant region NAS
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 Mapped by significant region TAS[9694792]
C9orf3 chromosome 9 open reading frame 3 Mapped by significant region IDA[15687497]
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) Mapped by significant region IEA
ASRGL1 asparaginase like 1 Mapped by significant region IEA
CASP5 caspase 5, apoptosis-related cysteine peptidase Mapped by significant region IEA
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 Mapped by significant region IEA
TLL1 tolloid-like 1 Mapped by Literature SNP IEA
PRSS22 protease, serine, 22 Mapped by significant region IEA
TPSB2 tryptase beta 2 (gene/pseudogene) Mapped by significant region NAS
MMP13 matrix metallopeptidase 13 (collagenase 3) Mapped by significant region IEA
CAPN14 calpain 14 Mapped by CNV IEA
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 Mapped by significant region IEA
DPEP1 dipeptidase 1 (renal) Mapped by significant region IEA